{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:56:37Z","timestamp":1764276997146,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,9]],"date-time":"2020-02-09T00:00:00Z","timestamp":1581206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Effective analgesic alternatives to interscalene brachial plexus block are sought for shoulder surgery. Peri\u2010articular infiltration analgesia is a novel, less invasive technique, but evidence surrounding its use is unclear. This systematic review and meta\u2010analysis aims to evaluate the utility of peri\u2010articular infiltration analgesia in shoulder surgery. We searched literature for trials comparing peri\u2010articular infiltration analgesia with control or with interscalene brachial plexus block. Control groups received no intervention, placebo or systemic opioids. The primary outcome was cumulative oral morphine equivalent consumption during the first 24\u00a0h postoperatively. Secondary outcomes included: rest pain scores up to 48\u00a0h; risk of side\u2010effects; and durations of post\u2010anaesthetic care unit and hospital stay. Data were pooled with random\u2010effects modelling. Seven trials (383 patients) were included. Compared with control, peri\u2010articular infiltration analgesia reduced 24\u2010h oral morphine consumption by a mean difference (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) of \u221238.0\u00a0mg (\u221265.5 to \u221210.5; p\u00a0=\u00a00.007). It also improved pain scores up to 6\u00a0h, 36\u00a0h and 48\u00a0h, with the greatest improvement observed at 0\u00a0h (\u22122.4 (\u22122.7 to \u22121.6); p\u00a0&lt;\u00a00.001). Peri\u2010articular infiltration analgesia decreased postoperative nausea and vomiting by an odds ratio (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) of 0.3 (0.1\u20130.7; p\u00a0=\u00a00.006). In contrast, peri\u2010articular infiltration analgesia was not different from interscalene brachial plexus block for analgesic consumption, pain scores or side\u2010effects. This review provides moderate evidence supporting peri\u2010articular infiltration for postoperative analgesia following shoulder surgery. The absence of difference between peri\u2010articular infiltration analgesia and interscalene brachial plexus block for analgesic outcomes suggests that these interventions are comparable, but further trials are needed to support this conclusion and identify the optimal peri\u2010articular infiltration technique.\n                  <\/jats:p>","DOI":"10.1111\/anae.14996","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:48:07Z","timestamp":1581295687000},"page":"1236-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peri\u2010articular infiltration analgesia for shoulder surgery: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"75","author":[{"given":"E. M.","family":"Yung","sequence":"first","affiliation":[{"name":"Department of Anesthesia University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Brull","sequence":"additional","affiliation":[{"name":"Department of Anesthesia University of Toronto Toronto ON Canada"},{"name":"Department of Anesthesia Women's College Hospital Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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