{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:38:34Z","timestamp":1793864314975,"version":"4.6.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Spinal cord stimulation at 10 kHz is a promising therapy for non\u2010surgical refractory back pain; however, published data are currently limited. We present a subanalysis of prospectively collected clinical outcome data for non\u2010surgical refractory back pain patients treated with 10 kHz spinal cord stimulation, from the independent cohorts of two previous studies (\n                    <jats:styled-content style=\"fixed-case\">SENZA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">SENZA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\n                    ). Clinical outcomes were evaluated at pre\u2010implantation (baseline), 3\u00a0months, 6\u00a0months and 12\u00a0months following 10 kHz spinal cord stimulator implantation. These included: pain relief; responder rate (\u2265\u00a050% pain relief from baseline); remission rate (\n                    <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                    \u2264\u00a03.0 cm); disability (Oswestry Disability Index(ODI)); and opioid use. At 3\u00a0months, average back pain decreased by 70% in the combined cohort (60% in the\n                    <jats:styled-content style=\"fixed-case\">SENZA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                    and 78% in the\n                    <jats:styled-content style=\"fixed-case\">SENZA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\n                    cohorts). This was sustained at 12\u00a0months, with a 73% back pain responder rate and 68% remission rate in the combined cohort. Leg pain relief results were generally comparable to those for back pain relief. At 12\u00a0months, the combined cohort had an average decrease in ODI scores of 15.7% points from baseline and opioid use more than halved. In conclusion, 10 kHz spinal cord stimulation reduced pain, disability and opioid consumption in non\u2010surgical refractory back pain subjects. Application of this therapy may improve the care of non\u2010surgical refractory back pain patients and reduce their opioid consumption.\n                  <\/jats:p>","DOI":"10.1111\/anae.15036","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:19:15Z","timestamp":1588915155000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["10 kHz spinal cord stimulation for the treatment of non\u2010surgical refractory back pain: subanalysis of pooled data from two prospective studies"],"prefix":"10.1111","volume":"75","author":[{"given":"A.","family":"Al\u2010Kaisy","sequence":"first","affiliation":[{"name":"The Pain Management and Neuromodulation Centre Guy's and St. Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Van Buyten","sequence":"additional","affiliation":[{"name":"Multidisciplinary Pain Centre AZ Nikolaas St Niklaas Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kapural","sequence":"additional","affiliation":[{"name":"Carolina's Pain Institute Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Amirdelfan","sequence":"additional","affiliation":[{"name":"IPM Medical Group, Inc. Walnut Creek CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gliner","sequence":"additional","affiliation":[{"name":"Clinical and Regulatory Affairs Nevro Corp."},{"name":"Nevro Corp. Redwood City CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Caraway","sequence":"additional","affiliation":[{"name":"Clinical and Regulatory Affairs Nevro Corp."},{"name":"Nevro Corp. Redwood City CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Subbaroyan","sequence":"additional","affiliation":[{"name":"Clinical and Regulatory Affairs Nevro Corp."},{"name":"Nevro Corp. Redwood City CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Edgar","sequence":"additional","affiliation":[{"name":"Commexus Ltd. Dunblane UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rotte","sequence":"additional","affiliation":[{"name":"Clinical and Regulatory Affairs Nevro Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34347"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00187-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.10.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181e70488"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/101053950301500202"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30970-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7555.1430"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30480-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00170.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2367"},{"key":"e_1_2_6_13_1","unstructured":"National Institute for Health and Care Excellence (NICE).Low back pain and sciatica in over 16s: assessment and management. NICE Guideline [NG59] London 2016.www.nice.org.uk\/guidance\/ng59"},{"key":"e_1_2_6_14_1","first-page":"258","article-title":"Spinal cord stimulation","volume":"16","author":"Moore DM","year":"2016","journal-title":"British Journal of Anaesthesia Education"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12264"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000144839.65524.E0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.07.028"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12095"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000774"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1403.2012.00530.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12594"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001418"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12294"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.720"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S188795"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12563"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx237"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1592401"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1890-8"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47792-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14236"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-018-0228-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30489-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.2014011685"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.15036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:07:01Z","timestamp":1761671221000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/anae.15036"],"URL":"https:\/\/doi.org\/10.1111\/anae.15036","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,8]]},"assertion":[{"value":"2020-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}