{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:11:16Z","timestamp":1785723076909,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Anaphylaxis in pregnancy is a rare but severe complication for both mother and infant. Population\u2010based data on anaphylaxis in pregnancy are lacking from mainland European countries. This multinational study presents the incidence, causative agents, management and maternal and infant outcomes of anaphylaxis in pregnancy. This descriptive multinational study used a combination of retrospective (Finnish medical registries) and prospective population\u2010based studies (\n                    <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                    , France, Belgium and the Netherlands) to identify cases of anaphylaxis. Sixty\u2010five cases were identified among 4,446,120 maternities (1.5 per 100,000 maternities; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    1.1\u20131.9). The incidence did not vary between countries. Approximately three\u2010quarters of reactions occurred at the time of delivery. The most common causes were antibiotics in 27 women (43%), and anaesthetic agents in 11 women (17%; including neuromuscular blocking drugs, 7), which varied between countries. Anaphylaxis had very poor outcomes for one in seven mothers and one in seven babies; the maternal case fatality rate was 3.2% (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    0.4\u201311.0) and the neonatal encephalopathy rate was 14.3% (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    4.8\u201330.3). Across Europe, anaphylaxis related to pregnancy is rare despite having a multitude of causative agents and different antibiotic prophylaxis protocols.\n                  <\/jats:p>","DOI":"10.1111\/anae.15069","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:50:34Z","timestamp":1590663034000},"page":"1469-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Anaphylaxis in pregnancy: a population\u2010based multinational European study"],"prefix":"10.1111","volume":"75","author":[{"given":"S. J.","family":"McCall","sequence":"first","affiliation":[{"name":"National Perinatal Epidemiology Unit Nuffield Department of Population Health University of Oxford  UK"},{"name":"Center for Research on Population and Health American University of Beirut  Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010P.","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris CRESS Obstetrical Perinatal and Pediatric Epidemiology Research Team EPOP\u00e9 INSERM U1153 Paris France"},{"name":"Department of Anesthesiology and Critical Care H\u00f4pital Armand Trousseau Assistance Publique des H\u00f4pitaux de Paris  France"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation Research Network Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"\u00c4yr\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gissler","sequence":"additional","affiliation":[{"name":"Information Services Department THL Finnish Institute for Health and Welfare Helsinki Finland"},{"name":"Department of Neurobiology, Care Sciences and Society Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2010H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"},{"name":"Research Laboratory for Human Reproduction Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Van Leeuw","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology Center (CEpiP) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Deneux\u2010Tharaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris CRESS Obstetrical Perinatal and Pediatric Epidemiology Research Team EPOP\u00e9 INSERM U1153 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Kurinczuk","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Unit Nuffield Department of Population Health University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Knight","sequence":"additional","affiliation":[{"name":"National Perinatal Epidemiology Unit Nuffield Department of Population Health University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the INOSS collaboration","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2008.05.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a706c7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15041"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.04.047"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12316"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.02.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00609.x"},{"key":"e_1_2_6_9_1","first-page":"181","article-title":"The Belgian Obstetric Surveillance System to monitor severe maternal morbidity","volume":"9","author":"Vandenberghe G","year":"2017","journal-title":"Facts, Views and Vision in ObGyn"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13493"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14639230110119234"},{"key":"e_1_2_6_12_1","unstructured":"OpenClinica.OpenClinica Enterprise 2020.https:\/\/www.openclinica.com\/clinical-trial-software-solutions\/enterprise-edc-system(accessed 25\/03\/2020)."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.005"},{"key":"e_1_2_6_14_1","first-page":"655","article-title":"Anaphylaxis to cefazolin during labor secondary to prophylaxis for group B Streptococcus: a case report","volume":"51","author":"Jao M\u2010S","year":"2006","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_6_15_1","first-page":"381","article-title":"Anaphylaxis in labor secondary to prophylaxis against group B Streptococcus. 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