{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:41:11Z","timestamp":1780774871662,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Deep neuromuscular block aims to improve operative conditions during laparoscopic surgery with a lower intra\u2010abdominal pressure. Studies are conflicting on whether meaningful improvements in quality of recovery occur beyond emergence, and whether lower intra\u2010abdominal pressure is achieved. In this pragmatic randomised trial with 1:1 allocation, adults undergoing elective laparoscopic surgery were allocated to moderate neuromuscular block reversed with neostigmine, or deep neuromuscular block reversed with sugammadex. Allocation was revealed to the anaesthetist only. Primary outcome was cognitive recovery of the Postoperative Quality of Recovery Scale, 7\u00a0days after surgery. Secondary outcomes included recovery in other domains of the Postoperative Quality of Recovery Scale at 15\u00a0min and 40\u00a0min; days 1, 3, 7, 14; and 1 and 3\u00a0months after surgery. Chi\u2010square test was used for the primary outcome, and generalised linear mixed model for recovery over time between groups. Of 350 participants randomised, 140 (deep) and 144 (moderate) were analysed for the primary outcome. There was no difference in the Postoperative Quality of Recovery Scale cognitive domain at day 7 (deep 92.9% vs. moderate 91.8%, OR 1.164; 95%CI 0.486\u20132.788, p\u00a0=\u00a00.826), or at any other time\u2010point. No significant difference was observed for physiological, emotive, activities of daily living, nociception, or overall recovery. Length of stay in the recovery area (mean (SD) deep 108 (58) vs. moderate 109 (57) min, p\u00a0=\u00a00.78) and hospital (1.8 (1.9) vs. 2.6 (3.5) days, p\u00a0=\u00a00.019) was not different. Intra\u2010abdominal pressure and surgical operating conditions were not different between groups. Deep neuromuscular block did not improve quality of recovery compared with moderate neuromuscular block in operative laparoscopic surgery over a 1\u2010h duration.<\/jats:p>","DOI":"10.1111\/anae.15094","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T11:36:01Z","timestamp":1589283361000},"page":"1153-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A randomised controlled trial comparing deep neuromuscular blockade reversed with sugammadex with moderate neuromuscular block reversed with neostigmine"],"prefix":"10.1111","volume":"75","author":[{"given":"S.","family":"Boggett","sequence":"first","affiliation":[{"name":"Department of Surgery University of Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chahal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Peri\u2010operative and Pain Medicine Peter MacCallum Cancer Centre Melbourne Vic. Australia"},{"name":"Centre for Integrated Critical Care Department of Medicine and Radiology University of Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Royal Women's Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Peri\u2010operative and Pain Medicine Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Peri\u2010operative and Pain Medicine Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Peri\u2010operative and Pain Medicine Peter MacCallum Cancer Centre Melbourne Vic. Australia"},{"name":"Centre for Integrated Critical Care Department of Medicine and Radiology University of Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bowyer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Royal Melbourne Hospital Melbourne Vic. Australia"},{"name":"Department of Surgery University of Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Royse","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne Vic. Australia"},{"name":"Department of Cardiothoracic Surgery Royal Melbourne Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Royse","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne Vic. Australia"},{"name":"Department of Anaesthesia and Pain Management Royal Melbourne Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD012763","article-title":"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults","volume":"8","author":"Hristovska AM","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex116"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000884"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200405000-00009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.09.043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000316"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002920"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000360"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.09.027"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1994.tb03889.x"},{"key":"e_1_2_6_12_1","first-page":"e9","article-title":"Effect of pneumoperitoneum on renal tissue oxygenation and blood flow in a rat model","volume":"77","author":"Wiesenthal JD","year":"2011","journal-title":"Journal of Urology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001531"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1297-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14682"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-018-00915-w"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d960a9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318299f72b"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14402"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003511"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001433"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.23736\/S0375-9393.17.11916-4","article-title":"Quality of recovery after gastroscopy, colonoscopy, or both endoscopic procedures: an observational pilot study","volume":"83","author":"Brumby AM","year":"2017","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12273"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2019.02.014"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S100921"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3633-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet377"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0495-x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135412"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000992"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000198252"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fanae.15094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:38:19Z","timestamp":1761680299000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,12]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/anae.15094"],"URL":"https:\/\/doi.org\/10.1111\/anae.15094","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,12]]},"assertion":[{"value":"2020-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}