{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:00Z","timestamp":1787013840832,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Peri\u2010operative lidocaine infusion warrants investigation in bariatric surgery because obese patients present different physiological and pharmacological risks. This single\u2010centre, prospective, randomised double\u2010blind placebo\u2010controlled study enrolled obese patients scheduled for laparoscopic bariatric surgery using an enhanced recovery protocol. Patients received either lidocaine (bolus of 1.5\u00a0mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , then a continuous infusion of 2\u00a0mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .h\n                    <jats:sup>\u22121<\/jats:sup>\n                    until the end of the surgery, then 1\u00a0mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .h\n                    <jats:sup>\u22121<\/jats:sup>\n                    for 1\u00a0h in the recovery area) or identical volumes and rates of 0.9% saline. The primary outcome was the consumption of the equivalent of oxycodone consumption over the first 3 postoperative days. Secondary outcomes were: postoperative pain; incidence of nausea and vomiting; bowel function recovery; and lengths of stay in the recovery area and in hospital. Plasma concentrations of lidocaine were measured. On the 178 patients recruited, data were analysed from 176. The median (IQR [range]) equivalent intravenous oxycodone consumption was 3.3\u00a0mg (0.0\u20136.0 [0.0\u201314.5]) and 5.0\u00a0mg (3.3\u20137.0 [3.3\u201320.0]) in the lidocaine and saline groups, respectively (difference between medians (95%CI): 1.7 (0.6\u20133.4) mg; p\u00a0=\u00a00.004). Length of stay in the recovery area, postoperative pain, nausea and vomiting, day of recovery of bowel function, and length of stay in hospital were not different between groups. Mean (SD) lidocaine plasma concentrations were 2.44 (0.70) \u00b5g.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.77 (0.51) \u00b5g.ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    at the end of surgery and 1 hour after the end of infusion, respectively. Lidocaine infusion during bariatric surgery resulted in a clinically non\u2010relevant difference in postoperative oxycodone consumption.\n                  <\/jats:p>","DOI":"10.1111\/anae.15150","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T04:04:35Z","timestamp":1592712275000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of intra\u2010operative intravenous lidocaine on opioid consumption after bariatric surgery: a prospective, randomised, blinded, placebo\u2010controlled study"],"prefix":"10.1111","volume":"76","author":[{"given":"F.","family":"Plass","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nicolle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zamparini","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Al Issa","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Fiant","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Le Roux","sequence":"additional","affiliation":[{"name":"Department of Digestive and Bariatric Surgery CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. O.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alv\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Digestive and Bariatric Surgery CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-8610","authenticated-orcid":false,"given":"J.\u2010L.","family":"Hanouz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Peri\u2010operative Care CHU de Caen Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161365.GL"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3450-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13101"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3492-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318174df8b"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002458"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-019-03821-8"},{"key":"e_1_2_6_10_1","first-page":"CD009642","article-title":"Continuous intravenous peri\u2010operative lidocaine infusion for postoperative pain and recovery in adults","volume":"6","author":"Weibel S","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001527"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-1077-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-019-04340-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-1079-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000317"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.02.010"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.11.019"},{"key":"e_1_2_6_20_1","first-page":"157","article-title":"Postoperative pulmonary complications, early mortality, and hospital stay following noncardiothoracic surgery:a multicenter study by the Peri\u2010operative Research Network Investigators","volume":"152","author":"Fernandez\u2010Bustamante A","year":"2017","journal-title":"Journal of the American Medical Association: Surgery"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:41:46Z","timestamp":1761691306000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,21]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/anae.15150"],"URL":"https:\/\/doi.org\/10.1111\/anae.15150","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,21]]},"assertion":[{"value":"2020-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}