{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:43:16Z","timestamp":1792122196561,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The effect of intra\u2010operative intravenous methadone on quality of postoperative recovery was compared with morphine after laparoscopic gastroplasty. We included 137 adult patients with a body mass index &gt;\u00a035\u00a0kg.m\n                    <jats:sup>\u22122<\/jats:sup>\n                    who underwent bariatric surgery. Patients were allocated at random to receive either intra\u2010operative methadone (n\u00a0=\u00a069) or morphine (n\u00a0=\u00a068). All patients received the same postoperative care and analgesia. The primary outcome of postoperative quality of recovery was assessed using the Quality of Recovery\u201040 questionnaire total score 24\u00a0h after surgery. Secondary outcomes were assessed in the post\u2010anaesthesia care unit the night of the day of surgery (T1), in the morning after surgery (T2); and at night on the day following surgery (T3). The median (IQR [range]) total Quality of Recovery\u201040 questionnaire score of 194 (190\u2013197 [165\u2013200]) was higher (p\u00a0&lt;\u00a00.0001) in the methadone group compared with the score of 181 (174\u2013185.5 [121\u2013200]) in the morphine group. In the post\u2010anaesthesia care unit, the pain burden; incidence of nausea and vomiting; rescue morphine dose; and time to discharge, were significantly lower in the methadone group. On the ward, the methadone group had a lower: incidence of rescue morphine requests at T1 (5.8 vs. 54.4%, p\u00a0&lt;\u00a00.0001) and T2 (0 vs. 20.1%, p\u00a0&lt;\u00a00.0001); and incidence of nausea (21.7 vs. 41.2%, p\u00a0=\u00a00.014), compared with the morphine group. We conclude that intra\u2010operative intravenous methadone improved quality of recovery in patients who underwent laparoscopic gastroplasty, compared with intra\u2010operative morphine. Methadone also reduced postoperative pain, postoperative opioid consumption and the incidence of opioid\u2010related adverse events.\n                  <\/jats:p>","DOI":"10.1111\/anae.15173","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T02:28:33Z","timestamp":1595903313000},"page":"199-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intra\u2010operative methadone effect on quality of recovery compared with morphine following laparoscopic gastroplasty: a randomised controlled trial"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-0664","authenticated-orcid":false,"given":"J. P. J.","family":"Pontes","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Santa Genoveva Hospital Complex Uberl\u00e2ndia Minas Gerais Brazil"},{"name":"Department of Anaesthesiology Santa Genoveva Hospital Complex Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-4182","authenticated-orcid":false,"given":"F. R.","family":"Braz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Santa Genoveva Hospital Complex Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-6820","authenticated-orcid":false,"given":"N. S. P.","family":"M\u00f3dolo","sequence":"additional","affiliation":[{"name":"Botucatu School of Medicine UNESP S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-4407","authenticated-orcid":false,"given":"L. A.","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Surgery Santa Genoveva Hospital Complex Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-5250","authenticated-orcid":false,"given":"J. A. G.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Surgery Santa Genoveva Hospital Complex Uberl\u00e2ndia Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-7289","authenticated-orcid":false,"given":"L. H.","family":"Navarro e Lima","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Queens University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2562-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-010-0217-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_6_5_1","first-page":"504","article-title":"Prevalence of self\u2010reported symptoms after gastric bypass surgery for obesity","volume":"151","author":"Gribsholt SB","year":"2016","journal-title":"Journal of the American Medical Association: Surgery"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes308"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes465"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002755"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181fec9a3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2003\/236718"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02220-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004472"},{"key":"e_1_2_6_13_1","first-page":"122","article-title":"Comparison of postoperative analgesia with methadone versus morphine in cardiac surgery","volume":"68","author":"Carvalho AC","year":"2018","journal-title":"Revista Brasileira de Anestesiologia"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d8a095"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S172235"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000633"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001609"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003464"},{"key":"e_1_2_6_19_1","first-page":"1274","volume-title":"Clinical Anesthesia","author":"Bucklin BA","year":"2013"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1777-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/64.1.48"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013366"},{"key":"e_1_2_6_23_1","unstructured":"SchwerdtfegerCMMA. Qualidade da recupera\u00e7\u00e3o em anestesia: abordagem da satisfa\u00e7\u00e3o de pacientes submetidos a procedimentos anest\u00e9sicos. Hospital de reabilita\u00e7\u00e3o de anomalias craniofaciais. 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