{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:29:00Z","timestamp":1762918140825,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011088","name":"UCL Hospitals Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>COVID\u201019, the respiratory disease caused by SARS\u2010CoV\u20102, is thought to cause a milder illness in pregnancy with a greater proportion of asymptomatic carriers. This has important implications for the risk of patient\u2010to\u2010staff, staff\u2010to\u2010staff and staff\u2010to\u2010patient transmission among health professionals in maternity units. The aim of this study was to investigate the prevalence of previously undiagnosed SARS\u2010CoV\u20102 infection in health professionals from two tertiary\u2010level maternity units in London, UK, and to determine associations between healthcare workers\u2019 characteristics, reported symptoms and serological evidence of prior SARS\u2010CoV\u20102 infection. In total, 200 anaesthetists, midwives and obstetricians, with no previously confirmed diagnosis of COVID\u201019, were tested for immune seroconversion using laboratory IgG assays. Comprehensive symptom and medical histories were also collected. Five out of 40 (12.5%; 95%CI 4.2\u201326.8%) anaesthetists, 7\/52 (13.5%; 95%CI 5.6\u201325.8%) obstetricians and 17\/108 (15.7%; 95%CI 9.5\u201324.0%) midwives were seropositive, with an overall total of 29\/200 (14.5%; 95%CI 9.9\u201320.1%) of maternity healthcare workers testing positive for IgG antibodies against SARS\u2010CoV\u20102. Of those who had seroconverted, 10\/29 (35.5%) were completely asymptomatic. Fever or cough were only present in 6\/29 (21%) and 10\/29 (35%) respectively. Anosmia was the most common symptom occurring in 15\/29 (52%) seropositive participants and was the only symptom that was predictive of positive seroconversion (OR 18; 95%CI 6\u201355). Of those who were seropositive, 59% had not self\u2010isolated at any point and continued to provide patient care in the hospital setting. This is the largest study of baseline immune seroconversion in maternity healthcare workers conducted to date and reveals that one out of six were seropositive, of whom one out of three were asymptomatic. This has significant implications for the risk of occupational transmission of SARS\u2010CoV\u20102 for both staff and patients in maternity units. Regular testing of staff, including asymptomatic staff should be considered to reduce transmission risk.<\/jats:p>","DOI":"10.1111\/anae.15229","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T19:38:45Z","timestamp":1597088325000},"page":"1614-1619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A cross\u2010sectional study of immune seroconversion to SARS\u2010CoV\u20102 in frontline maternity health professionals"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-4321","authenticated-orcid":false,"given":"S.","family":"Bampoe","sequence":"first","affiliation":[{"name":"Centre for Anaesthesia and Peri\u2010operative Medicine University College London London UK"},{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Northwick Park Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Neall","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sceales","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Caulfield","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-9856","authenticated-orcid":false,"given":"D.","family":"Siassakos","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust London UK"},{"name":"University College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-2703","authenticated-orcid":false,"given":"P. M.","family":"Odor","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesia and Peri\u2010operative Medicine University College London London UK"},{"name":"University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Office for National Statistics.Coronavirus (COVID\u201019) Infection Survey Coronavirus (COVID\u201019) Infection Survey pilot: 28 May 2020.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/bulletins\/coronaviruscovid19infectionsurveypilot\/28may2020(accessed 01\/06\/2020)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8279"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009316"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6130"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31484-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.06.029"},{"key":"e_1_2_6_8_1","unstructured":"Public Health England.Evaluation of the Abbott SARS\u2010CoV\u20102 IgG for the detection of anti\u2010SARS\u2010 CoV\u20102 antibodies.2020.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/890566\/Evaluation_of_Abbott_SARS_CoV_2_IgG_PHE.pdf(accessed 23\/07\/2020)."},{"key":"e_1_2_6_9_1","unstructured":"US Food and Drug Administration.EUA Authorized Serology Test Performance.2020.https:\/\/www.fda.gov\/medical-devices\/emergency-situations-medical-devices\/eua-authorized-serology-test-performance(accessed 10\/06\/2020)."},{"key":"e_1_2_6_10_1","unstructured":"Weekly Coronavirus Disease 2019 (COVID\u201019) Surveillance Report. Week 24.2020.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/891721\/Weekly_COVID19_Surveillance_Report_-_week_24.pdf(accessed 20\/06\/2020)."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2009758"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/cid\/ciw841","article-title":"Viral shedding and transmission potential of asymptomatic and paucisymptomatic influenza virus infections in the community","volume":"64","author":"Ip DKM","year":"2017","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2107"},{"key":"e_1_2_6_14_1","unstructured":"Office for National Statistics.Births in England and Wales: 2018.2019.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/livebirths\/bulletins\/birthsummarytablesenglandandwales\/2018(accessed 18\/06\/2020)"},{"key":"e_1_2_6_15_1","unstructured":"MBRRACE\u2010UK.Perinatal Mortality Surveillance Report UK Perinatal Deaths for Births from January to December 2016.2018.https:\/\/www.npeu.ox.ac.uk\/downloads\/files\/mbrrace-uk\/reports\/MBRRACE-UK%20Perinatal%20Surveillance%20Summary%20Report%20for%202016%20-%20June%202018.pdf(accessed 18\/06\/2020)."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"e_1_2_6_17_1","first-page":"1846","article-title":"Possible vertical transmission of SARS\u2010CoV\u20102 from an infected mother to her newborn","volume":"323","author":"Dong L","year":"2020","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104447"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903490"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:48:01Z","timestamp":1761670081000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,10]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/anae.15229"],"URL":"https:\/\/doi.org\/10.1111\/anae.15229","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"type":"print","value":"0003-2409"},{"type":"electronic","value":"1365-2044"}],"subject":[],"published":{"date-parts":[[2020,8,10]]},"assertion":[{"value":"2020-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}