{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:01Z","timestamp":1787013841063,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sleep apnoea is associated with negative outcomes following general anaesthesia. Current recommendations suggest using short\u2010acting anaesthetic agents in preference to standard agents to reduce this risk, but there is currently no evidence to support this. This randomised controlled triple\u2010blind trial tested the hypothesis that a combination of short\u2010acting agents (desflurane\u2010remifentanil) would reduce the postoperative impact of general anaesthesia on sleep apnoea severity compared with standard agents (sevoflurane\u2010fentanyl). Sixty patients undergoing hip arthroplasty under general anaesthesia were randomised to anaesthesia with desflurane\u2010remifentanil or sevoflurane\u2010fentanyl. Respiratory polygraphy was performed before surgery and on the first and third postoperative nights. The primary outcome was the supine apnoea\u2010hypopnoea index on the first postoperative night. Secondary outcomes were the supine apnoea\u2010hypopnoea index on the third postoperative night, and the oxygen desaturation index on the first and third postoperative nights. Additional outcomes included intravenous morphine equivalent consumption and pain scores on postoperative days 1, 2 and 3. Pre\u2010operative sleep study data were similar between groups. Mean (95%CI) values for the supine apnoea\u2010hypopnoea index on the first postoperative night were 18.9 (12.7\u201325.0) and 21.4 (14.2\u201328.7) events.h\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively, in the short\u2010acting and standard anaesthesia groups (p\u00a0=\u00a00.64). Corresponding values on the third postoperative night were 28.1 (15.8\u201340.3) and 38.0 (18.3\u201357.6) events.h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (p\u00a0=\u00a00.34). Secondary sleep\u2010 and pain\u2010related outcomes were generally similar in the two groups. In conclusion, short\u2010acting anaesthetic agents did not reduce the impact of general anaesthesia on sleep apnoea severity compared with standard agents. These data should prompt an update of current recommendations.\n                  <\/jats:p>","DOI":"10.1111\/anae.15236","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T03:47:59Z","timestamp":1598586479000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of short\u2010acting vs. standard anaesthetic agents on obstructive sleep apnoea: a randomised, controlled, triple\u2010blind trial"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1311","authenticated-orcid":false,"given":"E.","family":"Albrecht","sequence":"first","affiliation":[{"name":"Department of Anaesthesia University Hospital of Lausanne University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bayon","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep University Hospital of Lausanne University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hirotsu","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep University Hospital of Lausanne University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Heinzer","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep University Hospital of Lausanne University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60734-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00043-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01150-2018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4654"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043104"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2013.01.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3068"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.1784"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.2.254"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes308"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000051"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.4783"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9344-y"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13362"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000136472.01079.95"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200102000-00008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2929-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124343"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14769"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew028"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181da832d"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01697.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","unstructured":"KimJ TranK SealK et\u00a0al.Interventions for the treatment of obstructive sleep apnea in adults: a health technology assessment. Canadian Agency for Drugs and Technologies Health.2017.https:\/\/www.cadth.ca\/dv\/interventions\u2010treatment\u2010obstructive\u2010sleep\u2010apnea\u2010adults\u2010health\u2010technology\u2010assessment(accessed 20\/07\/2020)","DOI":"10.1016\/j.jval.2017.08.1513"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280212445834"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-015-0442-8"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/2014GL062785"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14657"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000407"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14582"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.04.053"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex050"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000040"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000041"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30057-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00006-0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1302941"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:26:23Z","timestamp":1761686783000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/anae.15236"],"URL":"https:\/\/doi.org\/10.1111\/anae.15236","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"assertion":[{"value":"2020-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}