{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:14:43Z","timestamp":1775978083303,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Extended\u2010release opioids are often prescribed to manage postoperative pain despite being difficult to titrate to analgesic requirements and their association with long\u2010term opioid use. An Australian\/New Zealand organisational position statement released in March 2018 recommended avoiding extended\u2010release opioid prescribing for acute pain. This study aimed to evaluate the impact of this organisational position statement on extended\u2010release opioid prescribing among surgical inpatients. Secondary objectives included predictors and clinical outcomes of prescribing extended\u2010release opioids among surgical inpatients. We conducted a retrospective, dual centre, 11\u2010month before\u2010and\u2010after study and time\u2010series analysis by utilising electronic medical records from two teaching hospitals in Sydney, Australia. The primary outcome was the proportion of patients prescribed an extended\u2010release opioid. For surgical patients prescribed any opioid (n\u2009=\u200916,284), extended\u2010release opioid prescribing decreased after the release of the position statement (38.4% before vs. 26.6% after, p\u2009&lt;\u20090.001), primarily driven by a reduction in extended\u2010release oxycodone (31.1% before vs. 14.1% after, p\u2009&lt;\u20090.001). There was a 23% immediate decline in extended\u2010release opioid prescribing after the position statement release (p\u2009&lt;\u20090.001), followed by an additional 0.2% decline per month in the following months. Multivariable regression showed that the release of the position statement was associated with a decrease in extended\u2010release opioid prescribing (OR 0.54, 95%CI 0.50\u20130.58). Extended\u2010release opioid prescribing was also associated with increased incidence of opioid\u2010related adverse events (OR 1.52, 95%CI 1.35\u20131.71); length of stay (RR 1.44, 95%CI 1.39\u20131.51); and 28\u2010day re\u2010admission (OR 1.26, 95%CI 1.12\u20131.41). Overall, a reduction in extended\u2010release opioid prescribing was observed in surgical inpatients following position statement release.<\/jats:p>","DOI":"10.1111\/anae.15500","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T13:17:30Z","timestamp":1620307050000},"page":"1607-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of an Australian\/New Zealand organisational position statement on extended\u2010release opioid prescribing among surgical inpatients: a dual centre before\u2010and\u2010after study"],"prefix":"10.1111","volume":"76","author":[{"given":"R.","family":"Awadalla","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health School of Pharmacy University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Prince of Wales Hospital Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kemp\u2010Casey","sequence":"additional","affiliation":[{"name":"Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences University of South Australia Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gnjidic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Pharmacy University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Patanwala","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health School of Pharmacy University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Stevens","sequence":"additional","affiliation":[{"name":"University of New South Wales Sydney NSW Australia"},{"name":"University of Notre Dame Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Begley","sequence":"additional","affiliation":[{"name":"Department of Pain Management Prince of Wales Hospital Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bugeja","sequence":"additional","affiliation":[{"name":"Department of Pain Management Prince of Wales Hospital Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Penm","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Prince of Wales Hospital Randwick NSW Australia"},{"name":"Faculty of Medicine and Health School of Pharmacy University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"e025840","article-title":"Combating escalating harms associated with 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