{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:00:03Z","timestamp":1793592003037,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The association between intra\u2010operative hypotension and postoperative acute kidney injury, mortality and length of stay has not been comprehensively evaluated in a large single\u2010centre hip fracture population. We analysed electronic anaesthesia records of 1063 patients undergoing unilateral hip fracture surgery, collected from 2015 to 2018. Acute kidney injury, 3\u2010, 30\u2010 and 365\u2010day mortality and length of stay were evaluated to assess the relationship between intra\u2010operative hypotension absolute values (\u2264 55, 60, 65, 70 and 75\u2009mmHg) and duration of hypotension. The rate of acute kidney injury was 23.7%, mortality at 3\u2010, 30\u2010 and 365 days was 3.7%, 8.0% and 25.3%, respectively, and median (IQR [range]) length of stay 8 (6\u201312 [0\u201399])\u2009days. Median (IQR [range]) time \u2264 MAP 55, 60, 65, 70 and 75\u2009mmHg was 0 (0\u20130.5[0\u201372.1]); 0 (0\u20134.4 [0\u2013104.9]); 2.2 (0\u20138.7 [0\u2013144.2]); 6.6 (2.2\u201319.7 [0\u2013198.8]); 17.5 (6.6\u201337.1 [0\u2013216.3]) minutes, and percentage of surgery time below these thresholds was 1%, 2.5%, 7.9%, 12% and 21% respectively. There were some univariate associations between hypotension and mortality; however, these were no longer evident in multivariable analysis. Multivariable analysis found no association between hypotension and acute kidney injury. Acute kidney injury was associated with male sex, antihypertensive medications and cardiac\/renal comorbidities. Three\u2010day mortality was associated with delay to surgery ? 48 hours, whilst 30\u2010day and 365\u2010day mortality was associated with delay to surgery \u2265\u200948 hours, impaired cognition and cardiac\/renal comorbidities. While the rate of acute kidney injury was similar to other studies, use of vasopressors and fluids to reduce the time spent at hypotensive levels failed to reduce this complication. Intra\u2010operative hypotension at the levels observed in this cohort may not be an important determinant of acute kidney injury, postoperative mortality and length of stay.<\/jats:p>","DOI":"10.1111\/anae.15555","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:20:21Z","timestamp":1632403221000},"page":"164-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The effect of intra\u2010operative hypotension on acute kidney injury, postoperative mortality and length of stay following emergency hip fracture surgery"],"prefix":"10.1111","volume":"77","author":[{"given":"M. T.","family":"Kluger","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology University of Auckland Auckland New Zealand"},{"name":"Department of Anaesthesiology and Peri\u2010operative Medicine Waitemat\u0101 DHB Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M. K.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Peri\u2010operative Medicine Waitemat\u0101 DHB Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Borotkanics","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Faculty of Health and Environmental Sciences Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"van Schalkwyk","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Peri\u2010operative Medicine Auckland City Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Rice","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Auckland University of Technology Auckland New Zealand"},{"name":"Department of Anaesthesiology and Peri\u2010operative Medicine Waitemat\u0101 DHB Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Australian and New Zealand Hip Fracture Registry.Australian and New Zealand Hip Fracture Registery Annual Report of Hip Fracture Care 2020 August2020.https:\/\/anzhfr.org\/wp-content\/uploads\/2020\/09\/ANZHFR-2020-Annual-Report-FULL.pdf(accessed 02\/06\/2021)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13415"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002968"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2019.1591147"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000686"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000756"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001432"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000765"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182a10e26"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.01.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151459320920088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151458512473827"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2009.07.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2496-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.09.060"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.01.033"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.04.036"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1413-785220202803226779"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010017\u20100437\u20105"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B8.37497"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176259"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499019896237"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/TJAR.2019.65642"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2019.10.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.05.001"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151459318813976"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-020-02175-w"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003368"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000270724.40897.8e"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:29:30Z","timestamp":1761665370000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/anae.15555"],"URL":"https:\/\/doi.org\/10.1111\/anae.15555","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]},"assertion":[{"value":"2021-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}