{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:24:06Z","timestamp":1782411846756,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Stroke is a leading cause of death and disability, and is associated with a huge societal and economic burden. Interventions for the immediate treatment of ischaemic stroke due to large vessel occlusion are dependent on recanalisation of the occluded vessel. Trials have provided evidence supporting the efficacy of mechanical thrombectomy in ischaemic stroke due to large vessel occlusion. This has resulted in changes in management and organisation of stroke care worldwide. Major determinants of effectiveness of thrombectomy include: time between stroke onset and reperfusion; location of occlusion and local collateral perfusion; adequacy of reperfusion; patient age; and stroke severity. The role of anaesthetic technique on outcome remains controversial with published research showing conflicting results. As a result, choice of conscious sedation or general anaesthesia for mechanical thrombectomy is often dependent on individual operator choice or institutional preference. More recent randomised controlled trials have suggested that protocol\u2010driven general anaesthesia is no worse than conscious sedation and may even be associated with better outcomes. These and other studies have highlighted the importance of optimal blood pressure management as a major determinant of patient outcome. Anaesthetic management should be tailored to the individual patient and circumstances. Acute ischaemic stroke is a neurological emergency; clinicians should focus on minimising door\u2010to\u2010groin puncture time and the provision of high\u2010quality periprocedural care with a particular emphasis on the maintenance of an adequate blood pressure.<\/jats:p>","DOI":"10.1111\/anae.15586","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T04:03:37Z","timestamp":1641787417000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anaesthesia for mechanical thrombectomy: a narrative review"],"prefix":"10.1111","volume":"77","author":[{"given":"J. E.","family":"Dinsmore","sequence":"first","affiliation":[{"name":"Department of Anaesthesia St George\u2019s University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia St George\u2019s University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30034-1"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz162"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz163"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.11.006"},{"key":"e_1_2_16_6_1","unstructured":"NHS England.Clinical Commissioning policy: mechanical thrombectomy for acute ischaemic stroke.2018.https:\/\/www.england.nhs.uk\/wp\u2010content\/uploads\/2019\/05\/Mechanical\u2010thrombectomy\u2010for\u2010acute\u2010ischaemic\u2010stroke\u2010ERRATA\u201029\u201005\u201019.pdf(accessed 28\/06\/2021)."},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-014735"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004044"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030297"},{"issue":"175","key":"e_1_2_16_19_1","first-page":"e1","article-title":"Standards for providing safe acute ischaemic stroke thrombectomy services","volume":"72","author":"White PW","year":"2015","journal-title":"Clinical Radiology"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319832140"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_2_16_22_1","unstructured":"National Institute for Health and Care Excellence.Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. [NG128].2019.https:\/\/www.nice.org.uk\/guidance\/ng128\/chapter\/Recommendations#thrombectomy\u2010for\u2010people\u2010with\u2010acute\u2010ischaemic\u2010stroke(accessed 24\/08\/2021)."},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13647"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000661"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4159"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318549"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30407-6"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16623"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016554"},{"key":"e_1_2_16_30_1","first-page":"470","article-title":"Effect of general anaesthesia and conscious sedation during endovascular therapy on infarct growth and clinical outcomes in acute ischaemic stroke: a randomized clinical trial","volume":"75","author":"Simonsen CZ","year":"2018","journal-title":"Journal of the American Medical Association. 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