{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:19:18Z","timestamp":1791296358150,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Traumatic brain injury is the alteration in brain function due to an external force. It is common and affects millions of people worldwide annually. The World Health Organization estimates that 90% of global deaths caused by injuries occur in low\u2010 and middle\u2010income countries, with traumatic brain injury contributing up to half of these trauma\u2010related deaths. Patients with traumatic brain injury in low\u2010 and middle\u2010income countries have twice the odds of dying compared with their counterparts in high\u2010income countries. Sedation is a key element of care in the management of traumatic brain injury, used for its neuroprotective effects and to prevent secondary brain injury. While sedatives have the potential to improve outcomes, they can be challenging to administer and have potentially dangerous complications. Sedation in low\u2010resource settings should aim to be effective, safe, affordable and feasible. In this paper, we summarise the indications for sedation in traumatic brain injury, the choice of sedative drugs and the pragmatic management and monitoring of sedated traumatic brain injury patients in low\u2010resource settings.<\/jats:p>","DOI":"10.1111\/anae.15621","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T04:03:37Z","timestamp":1641787417000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pragmatic sedation strategies to prevent secondary brain injury in low\u2010resource settings"],"prefix":"10.1111","volume":"77","author":[{"given":"R. K.","family":"Kayambankadzanja","sequence":"first","affiliation":[{"name":"School of Public Health Kamuzu University of Health Science Blantyre Malawi"},{"name":"Department of Anaesthesia and Intensive Care Queen Elizabeth Central Hospital Blantyre Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Samwel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bugando Medical Centre Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-7018","authenticated-orcid":false,"given":"T.","family":"Baker","sequence":"additional","affiliation":[{"name":"Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania"},{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-62539-5.00043-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.18.04532-0"},{"key":"e_1_2_8_5_1","first-page":"3","article-title":"Traumatic brain injuries in developing countries. 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