{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:42:05Z","timestamp":1773481325783,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Since the start of the COVID\u201019 pandemic, few studies have reported anaesthetic outcomes in parturients with SARS\u2010CoV\u20102 infection. We reviewed the labour analgesic and anaesthetic interventions utilised in symptomatic and asymptomatic parturients who had a confirmed positive test for SARS\u2010CoV\u20102 across 10 hospitals in the north\u2010west of England between 1 April 2020 and 31 May 2021. Primary outcomes analysed included the analgesic\/anaesthetic technique utilised for labour and caesarean birth. Secondary outcomes included a comparison of maternal characteristics, caesarean birth rate, maternal critical care admission rate along with adverse composite neonatal outcomes. A positive SARS\u2010CoV\u20102 test was recorded in 836 parturients with 263 (31.4%) reported to have symptoms of COVID\u201019. Neuraxial labour analgesia was utilised in 104 (20.4%) of the 509 parturients who went on to have a vaginal birth. No differences in epidural analgesia rates were observed between symptomatic and asymptomatic parturients (OR 1.03, 95%CI 0.64\u20131.67; p\u2009=\u20090.90). The neuraxial anaesthesia rate in 310 parturients who underwent caesarean delivery was 94.2% (95%CI 90.6\u201396.0%). The rates of general anaesthesia were similar in symptomatic and asymptomatic parturients (6% vs. 5.7%; p\u2009=\u20090.52). Symptomatic parturients were more likely to be multiparous (OR 1.64, 95%CI 1.19\u20132.22; p\u2009=\u20090.002); of Asian ethnicity (OR 1.54, 1.04\u20132.28; p\u2009=\u20090.03); to deliver prematurely (OR 2.16, 95%CI 1.47\u20133.19; p\u2009=\u20090.001); have a higher caesarean birth rate (44.5% vs. 33.7%; OR 1.57, 95%CI 1.16\u20132.12; p\u2009=\u20090.008); and a higher critical care utilisation rate both pre\u2010 (8% vs. 0%, p\u2009=\u20090.001) and post\u2010delivery (11% vs. 3.5%; OR 3.43, 95%CI 1.83\u20136.52; p\u2009=\u20090.001). Eight neonates tested positive for SARS\u2010CoV\u20102 while no differences in adverse composite neonatal outcomes were observed between those born to symptomatic and asymptomatic mothers (25.8% vs. 23.8%; OR 1.11, 95%CI 0.78\u20131.57; p\u2009=\u20090.55). In women with COVID\u201019, non\u2010neuraxial analgesic regimens were commonly utilised for labour while neuraxial anaesthesia was employed for the majority of caesarean births. Symptomatic women with COVID\u201019 are at increased risk of significant maternal morbidity including preterm birth, caesarean birth and peripartum critical care admission.<\/jats:p>","DOI":"10.1111\/anae.15672","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T13:23:14Z","timestamp":1646054594000},"page":"389-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Obstetric analgesia and anaesthesia in\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102\u2010positive parturients across 10 maternity units in the north\u2010west of England: a retrospective cohort study"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-1196","authenticated-orcid":false,"given":"K.","family":"Bhatia","sequence":"first","affiliation":[{"name":"Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Group of Obstetric Anaesthetists of Lancashire, Greater Manchester and Mersey Study Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.10.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100446"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2107"},{"key":"e_1_2_6_6_1","first-page":"817","article-title":"Maternal and neonatal morbidity and mortality among pregnant women with and without COVID\u201019 infection. The INTERCOVID multinational cohort study","volume":"175","author":"Villar J","year":"2021","journal-title":"Journal of the American Medical Association Paediatrics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3320"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.11.022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251123"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2020.04.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004856"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15105"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15313"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005592"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2021.103188"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2021.103063"},{"key":"e_1_2_6_17_1","unstructured":"NMPA Project Team.National maternity and perinatal audit: clinical report 2019. Based on births in NHS maternity services between 1st April 2016 and 31st March 2017. Royal College of Obstetricians and Gynaecologists.2019.https:\/\/maternityaudit.org.uk\/pages\/reports(accessed 01\/01\/ 2021)."},{"key":"e_1_2_6_18_1","unstructured":"National Institute for Health and Care Excellence.Caesarean section: clinical guideline [CG132] 2011.www.nice.org.uk\/guidance\/cg132(accessed 01\/02\/2021)."},{"key":"e_1_2_6_19_1","unstructured":"Royal College of Anaesthetists.Guidelines for the Provision of Anaesthesia Services for an Obstetric Population 2020.https:\/\/rcoa.ac.uk\/gpas\/chapter\u20109#chapter\u20107(accessed 5\/10\/ 2021)."},{"key":"e_1_2_6_20_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Classification of Urgency of Caesarean Section. A Continuum of Risk. Good Practice No 11.2010.https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/goodpractice11classificationofurgency.pdf(accessed 01\/08\/2021)."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2021.100937"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1937105"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.06.053"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15122"},{"key":"e_1_2_6_25_1","first-page":"e200553","article-title":"Personal protective equipment shortages during COVID\u201019: supply chain\u2010related causes and mitigation strategies","volume":"1","author":"Mehrotra P","year":"2020","journal-title":"Journal of the American Medical Association Health Forum."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tacc.2021.01.004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.2006.00150.x"},{"key":"e_1_2_6_28_1","volume-title":"Safely Delivered: A National Survey of Women's Experience of Maternity Care","author":"Redshaw M","year":"2014"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15599"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15292"},{"key":"e_1_2_6_31_1","first-page":"e186567","article-title":"United States state\u2010level variation in the use of neuraxial analgesia during labor for pregnant women","volume":"1","author":"Butwick AJ","year":"2018","journal-title":"Journal of the American Medical Association Network Open"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001622"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14852"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.15672","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.15672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:54:43Z","timestamp":1761699283000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.15672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/anae.15672"],"URL":"https:\/\/doi.org\/10.1111\/anae.15672","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"2021-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}