{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:37:52Z","timestamp":1792881472568,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Carbetocin or oxytocin are given routinely as first\u2010line uterotonic drugs following delivery of the neonate during caesarean delivery to prevent postpartum haemorrhage. Low doses may be as effective as high doses with a potential reduction in adverse effects. In this double\u2010blind, randomised, controlled, non\u2010inferiority trial, we assigned low\u2010risk patients undergoing elective caesarean delivery under spinal anaesthesia to one of four groups: carbetocin 20\u2009\u03bcg; carbetocin 100\u2009\u03bcg; oxytocin 0.5\u2009IU bolus + infusion; and oxytocin 5\u2009IU bolus + infusion. The study drug was given intravenously after delivery of the neonate. Uterine tone was assessed by the obstetrician 2, 5 and 10\u2009minutes after study drug administration according to an 11\u2010point verbal numerical rating scale (0\u2009=\u2009atonic, 10\u2009=\u2009excellent tone). The primary outcome measure was uterine tone 2\u2009min after study drug administration. The pre\u2010specified non\u2010inferiority margin was 1.2 points on the 11\u2010point scale. Secondary outcomes included uterine tone after 5 and 10\u2009minutes, use of additional uterotonics, blood loss and adverse effects. Data were available for 277 patients. Carbetocin 20\u2009\u03bcg resulting in uterine tone of (median (IQR [range])) 8 (7\u20138 [1\u201310]) was non\u2010inferior to carbetocin 100\u2009\u03bcg with tone 8 (7\u20139 [3\u201310]), median (95%CI) difference 0 (\u22120.44\u20130.44). Similarly, oxytocin 0.5\u2009IU with tone 7 (6\u20138 [3\u201310]) was non\u2010inferior to oxytocin 5\u2009IU with tone 8 (6\u20138 [2\u201310]), median (95%CI) difference 1 (0.11\u20131.89). Carbetocin 20\u2009\u03bcg was also non\u2010inferior to oxytocin 5\u2009IU, and oxytocin 0.5\u2009IU was non\u2010inferior to carbetocin 100\u2009\u03bcg. Uterine tone after 5 and 10\u2009minutes, use of additional uterotonics, blood loss and adverse effects were similar in all groups.<\/jats:p>","DOI":"10.1111\/anae.15714","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T05:28:21Z","timestamp":1648445301000},"page":"892-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Carbetocin vs. oxytocin at elective caesarean delivery: a double\u2010blind, randomised, controlled, non\u2010inferiority trial of low\u2010 and high\u2010dose regimens"],"prefix":"10.1111","volume":"77","author":[{"given":"F.","family":"McDonagh","sequence":"first","affiliation":[{"name":"Mount Sinai Hospital University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C. 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Mount Sinai Hospital University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Farine","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital University of Toronto  ON Canada"},{"name":"Department of Obstetrics and Gynaecology University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Balki","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Department of Obstetrics and Gynaecology University of Toronto  ON Canada"},{"name":"Mount Sinai Hospital University of Toronto  ON Canada"},{"name":"Department of Physiology University of Toronto  ON Canada"},{"name":"Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System  ON 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