{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:09:53Z","timestamp":1777752593767,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["10\/104\/06"],"award-info":[{"award-number":["10\/104\/06"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, the use of intravenous iron did not reduce the need for blood transfusion or reduce patient complications or length of hospital stay. As part of the trial protocol, serum was collected at randomisation and on the day of surgery. These samples were analysed in a central laboratory for markers of iron deficiency. We performed a secondary analysis to explore the potential interactions between pre\u2010operative markers of iron deficiency and intervention status on the trial outcome measures. Absolute iron deficiency was defined as ferritin &lt;30\u00a0\u03bcg.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; functional iron deficiency as ferritin 30\u2013100\u00a0\u03bcg.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    or transferrin saturation\u2009&lt;\u200920%; and the remainder as non\u2010iron deficient. Interactions were estimated using generalised linear models that included different subgroup indicators of baseline iron status. Co\u2010primary endpoints were blood transfusion or death and number of blood transfusions, from randomisation to 30\u2009days postoperatively. Secondary endpoints included peri\u2010operative change in haemoglobin, postoperative complications and length of hospital stay. Most patients had iron deficiency (369\/452 [82%]) at randomisation; one\u2010third had absolute iron deficiency (144\/452 [32%]) and half had functional iron deficiency (225\/452 [50%]). The change in pre\u2010operative haemoglobin with intravenous iron compared with placebo was greatest in patients with absolute iron deficiency, mean difference 8.9\u00a0g.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 95%CI 5.3\u201312.5; moderate in functional iron deficiency, mean difference 2.8\u00a0g.l\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 95%CI \u22120.1 to 5.7; and with little change seen in those patients who were non\u2010iron deficient. Subgroup analyses did not suggest that intravenous iron compared with placebo reduced the likelihood of death or blood transfusion at 30\u2009days differentially across subgroups according to baseline ferritin (p\u00a0=\u00a00.33 for interaction), transferrin saturation (p\u00a0=\u00a00.13) or in combination (p\u00a0=\u00a00.45), or for the number of blood transfusions (p\u00a0=\u00a00.06, 0.29, and 0.39, respectively). There was no beneficial effect of the use of intravenous iron compared with placebo, regardless of the metrics to diagnose iron deficiency, on postoperative complications or length of hospital stay.\n                  <\/jats:p>","DOI":"10.1111\/anae.15926","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T05:14:20Z","timestamp":1670476460000},"page":"320-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (\n                    <scp>PREVENTT<\/scp>\n                    ) trial"],"prefix":"10.1111","volume":"78","author":[{"given":"T.","family":"Richards","sequence":"first","affiliation":[{"name":"Division of Surgery University of Western Australia, Perkins South Building, Fiona Stanley Hospital, Murdoch  Perth WA Australia"},{"name":"Institute of Clinical Trials and Methodology and Division of Surgery University College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. F.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Critical Care Melbourne Medical School, The University of Melbourne  VIC Australia"},{"name":"Department of Anaesthesia Austin Health  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Clevenger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Royal National Orthopaedic Hospital  Stanmore UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Keegan","sequence":"additional","affiliation":[{"name":"Department of Haematology, PathWest Laboratory Medicine King Edward Memorial Hospital  Subiaco WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Abeysiri","sequence":"additional","affiliation":[{"name":"Division of Surgery University of Western Australia, Perkins South Building, Fiona Stanley Hospital, Murdoch  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rao Baikady","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia The Royal Marsden NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. W.","family":"Besser","sequence":"additional","affiliation":[{"name":"Department of Haematology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Browne","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork  Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Royal Papworth Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. C.","family":"Macdougall","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Berlin Institute of Health Centre for Regenerative Therapies; German Centre for Cardiovascular Research partner site Berlin; Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dahly","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork  Ireland"},{"name":"Health Research Board Clinical Research Facility University College Cork  Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The PREVENTT trial collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61381-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9861"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13840"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.514"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31539-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0870.1000269"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12918"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta25110"},{"key":"e_1_2_6_11_1","unstructured":"NHS Blood and Transplant.National 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