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Patients with haematological malignancy may require admission to critical care at the time of diagnosis or due to treatment related effects and complications. Although the prognosis for such patients requiring critical care has improved, there remain uncertainties in optimal clinical management. Identification of patients who will benefit from critical care admission is challenging and selective involvement of palliative care may help to reduce unnecessary and non\u2010beneficial treatments. While patients with haematological malignancy can present a challenge to critical care physicians, good outcomes can be achieved. In this narrative review, we provide a brief overview of relevant haematological malignancies for the critical care physician and a summary of recent treatment advances. Subsequently, we focus on critical care management for the patient with haematological malignancy including sepsis; acute respiratory failure; prevention and treatment of tumour lysis syndrome; thrombocytopaenia; and venous thromboembolism. We also discuss immunotherapeutic\u2010specific related complications and their management, including cytokine release syndrome and immune effector cell associated neurotoxicity syndrome associated with chimeric antigen receptor T\u2010cell therapy. While the management of haematological malignancies is highly specialised and increasingly centralised, acutely unwell patients often present to their local hospital with complications requiring critical care expertise. The aim of this review is to provide a contemporary overview of disease and management principles for non\u2010specialist critical care teams.<\/jats:p>","DOI":"10.1111\/anae.15955","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:54:25Z","timestamp":1674176065000},"page":"874-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management of adult patients with haematological malignancies in critical care"],"prefix":"10.1111","volume":"78","author":[{"given":"S.","family":"Fizza Haider","sequence":"first","affiliation":[{"name":"Royal Surrey Hospital NHS Foundation Trust  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sloss","sequence":"additional","affiliation":[{"name":"Department of Peri\u2010Operative Medicine (Critical Care) St Bartholomew's Hospital, Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jhanji","sequence":"additional","affiliation":[{"name":"Department of Critical Care Royal Marsden Hospital  London UK"},{"name":"Division of Cancer Biology Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Marsden Hospital  London UK"},{"name":"Division of Cancer Therapeutics Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-1232","authenticated-orcid":false,"given":"B.","family":"Creagh\u2010Brown","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Surrey Hospital NHS Foundation Trust  Guildford UK"},{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06502-2"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0780-z"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_13_5_1","unstructured":"Haematological Malignancy Research Network.Incidence statistics: incidence by diagnosis.https:\/\/hmrn.org\/statistics\/incidence(accessed 07\/07\/2022)."},{"key":"e_1_2_13_6_1","unstructured":"Haematological Malignancy Research Network.Survival statistics net survival by diagnosis.https:\/\/hmrn.org\/statistics\/survival(accessed 07\/07\/2022)."},{"key":"e_1_2_13_7_1","volume-title":"Risk Factors for Haemagological Malignancies: Immune\u2010Mediated Diseases, Body Mass Index and Magnetic Fields","author":"S\u00f6derberg K","year":"2006"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30003"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1922-8"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7713"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845414Y.0000000206"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003526"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.05.018"},{"key":"e_1_2_13_16_1","unstructured":"National Institute for Health and Care Excellence.Neutropenic sepsis: prevention and management in people with cancer. 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