{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:33:32Z","timestamp":1793414012067,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"publisher","award":["Duke\/Duke\u2010NUS\/RECA(pilot)\/2017\/0031"],"award-info":[{"award-number":["Duke\/Duke\u2010NUS\/RECA(pilot)\/2017\/0031"]}],"id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Identifying factors associated with persistent pain after breast cancer surgery may facilitate risk stratification and individualised management. Single\u2010population studies have limited generalisability as socio\u2010economic and genetic factors contribute to persistent pain development. Therefore, this prospective multicentre cohort study aimed to develop a predictive model from a sample of Asian and American women. We enrolled women undergoing elective breast cancer surgery at KK Women's and Children's Hospital and Duke University Medical Center. Pre\u2010operative patient and clinical characteristics and EQ\u20105D\u20103L health status were recorded. Pain catastrophising scale; central sensitisation inventory; coping strategies questionnaire\u2010revised; brief symptom inventory\u201018; perceived stress scale; mechanical temporal summation; and pressure\u2010pain threshold assessments were performed. Persistent pain was defined as pain score \u2265\u20093 or pain affecting activities of daily living 4\u00a0months after surgery. Univariate associations were generated using generalised estimating equations. Enrolment site was forced into the multivariable model, and risk factors with p\u2009&lt;\u20090.2 in univariate analyses were considered for backwards selection. Of 210 patients, 135 (64.3%) developed persistent pain. The multivariable model attained AUC\u00a0=\u00a00.807, with five independent associations: age (OR 0.85 95%CI 0.74\u20130.98 per 5\u2009years); diabetes (OR 4.68, 95%CI 1.03\u201321.22); pre\u2010operative pain score at sites other than the breast (OR 1.48, 95%CI 1.11\u20131.96); previous mastitis (OR 4.90, 95%CI 1.31\u201318.34); and perceived stress scale (OR 1.35, 95%CI 1.01\u20131.80 per 5 points), after adjusting for: enrolment site; pre\u2010operative pain score at the breast; pre\u2010operative overall pain score at rest; postoperative non\u2010steroidal anti\u2010inflammatory drug use; and pain catastrophising scale. Future research should validate this model and evaluate pre\u2010emptive interventions to reduce persistent pain risk.<\/jats:p>","DOI":"10.1111\/anae.15958","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T02:33:26Z","timestamp":1673663606000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk factors for persistent pain after breast cancer surgery: a multicentre prospective cohort study"],"prefix":"10.1111","volume":"78","author":[{"given":"H. S.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Women's Anaesthesia KK Women's and Children's Hospital, Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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