{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:22:09Z","timestamp":1792930929352,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Concerns relating to the negative environmental impacts of anaesthesia are increasing, and in recent years, there has been an environmentally motivated trend towards greater use of propofol\u2010based total intravenous anaesthesia. Consequently, the environmental burden of propofol waste and disposal, particularly into wastewater, has gained attention. Current literature reporting levels of propofol in wastewater are scarce and the threat this presents to the environment is unclear. We review the regulatory requirements for conducting an environmental risk assessment, with a focus on the process for analysing whether drugs or drug metabolites cause harm to aquatic species. Furthermore, we present a profile for the aquatic toxicity of propofol based on available data and discuss the implications of this for future practice.<\/jats:p>","DOI":"10.1111\/anae.15967","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T06:10:43Z","timestamp":1674627043000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Environmental risk assessment of propofol in wastewater: a narrative review of regulatory guidelines"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-7299","authenticated-orcid":false,"given":"J.","family":"Waspe","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Operating Services, Sheffield Teaching Hospitals NHS Trust University of Sheffield  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Operating Services, Sheffield Teaching Hospitals NHS Trust University of Sheffield  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Organisation for Economic Cooperation and Development.Pharmaceutical Residues in Freshwater: Hazards and Policy Responses OECD Studies on Water.2019.https:\/\/doi.org\/10.1787\/c936f42d\u2010en(accessed 20\/07\/2021)."},{"key":"e_1_2_8_3_1","volume-title":"Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks","author":"K\u00fcmmerer 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