{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:37:45Z","timestamp":1790815065843,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Virtual reality\u2010delivered psychological therapies have recently been investigated as non\u2010pharmacological management for acute and chronic pain. However, no virtual reality pain therapy software existed that met the needs of cancer patients with neuropathic pain. We created a bespoke virtual reality\u2010delivered pain therapy software programme to help cancer patients manage neuropathic pain incorporating guided visualisation and progressive muscle relaxation techniques, whilst minimising the risk of cybersickness in this vulnerable patient population. This randomised controlled pilot study evaluated the feasibility, acceptability, recruitment rates and risk of cybersickness of this pain therapy software programme. Clinical outcomes including opioid consumption, pain severity, pain interference and global quality of life scores were secondary aims. Of 87 eligible cancer patients with neuropathic pain, 39 were recruited (47%), allocated to either the intervention (20 patients, virtual reality pain therapy software programme) or control (19 patients, viewing virtual reality videos). Four patients withdrew before the 3\u2010month follow\u2010up (all in the control group). Pre\u2010existing dizziness (Spearman \u03c1 0.37, p\u00a0=\u00a00.02) and pre\u2010existing nausea (Spearman \u03c1 0.81, p\u2009&lt;\u20090.001) were significantly associated with risk of cybersickness in both groups. Patients in the intervention group reported less cybersickness, as well as tolerated and completed all therapy sessions. At 1\u2010 and 3\u2010month follow\u2010up, there were trends in the intervention group towards reductions in: oral morphine equivalent daily dose opioid consumption (\u22128\u00a0mg and \u22124\u00a0mg; vs. control: 0\u00a0mg and +15\u00a0mg respectively); modified Brief Pain Inventory pain severity (\u22120.4, \u22120.8; vs. control +0.4, \u22120.3); and pain interference (\u22120.9, \u22121.8; vs. control \u22120.2, \u22120.3) scores. The global quality of life subscale from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire\u2010C30 was not significantly changed between groups at 1 and 3 months (intervention: \u22125, \u22128; vs. control: +3, +4). This newly created virtual reality\u2010delivered pain therapy software programme was shown to be feasible and acceptable to cancer patients with neuropathic pain. These results will aid the design of a definitive multicentre randomised controlled trial.<\/jats:p>","DOI":"10.1111\/anae.15971","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T02:25:08Z","timestamp":1675391108000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Feasibility of virtual reality\u2010delivered pain psychology therapy for cancer\u2010related neuropathic pain: a pilot randomised controlled trial"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-6525","authenticated-orcid":false,"given":"A.","family":"Chuan","sequence":"first","affiliation":[{"name":"South Western Sydney Clinical School University of New South Wales  Sydney Australia"},{"name":"Department of Anaesthesia Liverpool Hospital  Sydney 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