{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:00Z","timestamp":1787013840543,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870070"],"award-info":[{"award-number":["81870070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011635","name":"Fuwai Hospital, Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Dexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6\u00a0\u03bcg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    for 10\u00a0min and then at 0.4\u00a0\u03bcg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    .h\n                    <jats:sup>\u22121<\/jats:sup>\n                    until the end of surgery; 326 control participants received comparable volumes of saline. We detected delirium in 98\/652 (15%) participants during the first seven postoperative days: 47\/326 after dexmedetomidine vs. 51\/326 after placebo, p\u00a0=\u00a00.62, adjusted relative risk (95%CI) 0.86 (0.56\u20131.33), p\u00a0=\u00a00.51. Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p\u00a0=\u00a00.040. Intra\u2010operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.\n                  <\/jats:p>","DOI":"10.1111\/anae.15983","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T05:04:09Z","timestamp":1676523849000},"page":"571-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery"],"prefix":"10.1111","volume":"78","author":[{"given":"H.\u2010B.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences Shenzhen (Sun Yat\u2010sen Cardiovascular Hospital, Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010N.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research &amp; Biometrics Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010X.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Fuwai Hospital, National Centre for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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