{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:04:25Z","timestamp":1787065465398,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["19891"],"award-info":[{"award-number":["19891"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K00414X\/1"],"award-info":[{"award-number":["MR\/K00414X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This retrospective cohort study on adults undergoing colectomy from 2010 to 2019 used linked primary (Clinical Practice Research Datalink), and secondary (Hospital Episode Statistics) care data to determine the prevalence of persistent postoperative opioid use following colectomy, stratified by pre\u2010admission opioid exposure, and identify associated predictors. Based on pre\u2010admission opioid exposure, patients were categorised as opioid\u2010na\u00efve, currently exposed (opioid prescription 0\u20136\u2009months before admission) and previously exposed (opioid prescription within 7\u201312\u2009months before admission). Persistent postoperative opioid use was defined as requiring an opioid prescription within 90\u2009days of discharge, along with one or more opioid prescriptions 91\u2013180\u2009days after hospital discharge. Multivariable logistic regression analyses were conducted to obtain odds ratios for predictors of persistent postoperative opioid use. Among the 93,262 patients, 15,081 (16.2%) were issued at least one opioid prescription within 90\u2009days of discharge. Of these, 6791 (45.0%) were opioid\u2010na\u00efve, 7528 (49.9%) were currently exposed and 762 (5.0%) were previously exposed. From the whole cohort, 7540 (8.1%) developed persistent postoperative opioid use. Patients with pre\u2010operative opioid exposure had the highest persistent use: 5317 (40.4%) from the currently exposed group; 305 (9.8%) from the previously exposed group; and 1918 (2.5%) from the opioid\u2010na\u00efve group. The odds of developing persistent opioid use were higher among individuals who used long\u2010acting opioid formulations in the 180\u2009days before colectomy than those who used short\u2010acting formulations (odds ratio 3.41 (95%CI 3.07\u20133.77)). Predictors of persistent opioid use included: previous opioid exposure; high deprivation index; multiple comorbidities; use of long\u2010acting opioids; white race; and open surgery. Minimally invasive surgical approaches were associated with lower odds of persistent opioid use and may represent a modifiable risk factor.<\/jats:p>","DOI":"10.1111\/anae.16055","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T10:49:54Z","timestamp":1685702994000},"page":"1081-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of persistent postoperative opioid use following colectomy: a population\u2010based cohort study from England"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-5346","authenticated-orcid":false,"given":"R. M.","family":"Baamer","sequence":"first","affiliation":[{"name":"Division of Pharmacy Practice and Policy, School of Pharmacy University of Nottingham  Nottingham UK"},{"name":"Department of Pharmacy Practice, Faculty of Pharmacy King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-4098","authenticated-orcid":false,"given":"D. J.","family":"Humes","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9228-6266","authenticated-orcid":false,"given":"L. S.","family":"Toh","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice and Policy, School of Pharmacy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Knaggs","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice and Policy, School of Pharmacy University of Nottingham  Nottingham UK"},{"name":"Pain Centre Versus Arthritis University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-5796","authenticated-orcid":false,"given":"D. N.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"},{"name":"David Greenfield Metabolic Physiology Unit, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research School of Life Sciences University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WeissAJ ElixhauserA.Trends in operating room procedures in U.S. hospitals 2001\u20132011.Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville MD: Agency for Healthcare Research and Quality (US) 2014."},{"key":"e_1_2_6_3_1","unstructured":"Health and Social Care Information Centre.Hospital Episode Statistics.http:\/\/www.hscic.gov.uk\/hes(accessed 25\/11\/2022)."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001429"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.00004"},{"key":"e_1_2_6_6_1","article-title":"Time trends and prescribing patterns of opioid drugs in UK primary care patients with non\u2010cancer pain: a retrospective cohort study","volume":"17","author":"Jani M","year":"2020","journal-title":"Public Library of Science Medicine"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15262"},{"key":"e_1_2_6_8_1","first-page":"158","article-title":"Current issues in the use of opioids for the management of postoperative pain: a review","volume":"157","author":"Macintyre PE","year":"2022","journal-title":"Journal of the American Medical Association Surgery"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001413"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003265"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/91"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5794"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4792"},{"key":"e_1_2_6_14_1","unstructured":"Medicines and Healthcare products Regulatory Agency.Drug Safety Update2020;14: 1\u201314."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1827"},{"key":"e_1_2_6_16_1","volume-title":"The Underestimated Cost of The Opioid Crisis","author":"Council of Economic Advisers (U.S.)","year":"2017"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32229-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1251"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01239"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003941"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw015"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003723"},{"key":"e_1_2_6_23_1","article-title":"New persistent opioid use after minor and major surgical procedures in US adults","volume":"152","author":"Brummett CM","year":"2017","journal-title":"Journal of the American Medical Association Surgery"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003403"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.04.017"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2021.20507"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz034"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005563"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx015"},{"key":"e_1_2_6_31_1","unstructured":"Ministry of Housing Communities and Local Government.National statistics: English indices of deprivation 2015.2015.https:\/\/www.gov.uk\/government\/statistics\/english\u2010indices\u2010of\u2010deprivation\u20102015(accessed 25\/11\/2022)."},{"key":"e_1_2_6_32_1","unstructured":"GOV.UK.Ethnicity facts and figures.2021.https:\/\/www.ethnicity\u2010facts\u2010figures.service.gov.uk\/style\u2010guide\/ethnic\u2010groups(accessed 25\/11\/2022)."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.217281"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004225"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15460"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-3941-4"},{"key":"e_1_2_6_38_1","article-title":"Long\u2010term trends in postoperative opioid prescribing, 1994 to 2014","volume":"4","author":"Chen CL","year":"2020","journal-title":"Journal of the American Academy of Orthopaedic Surgeons"},{"key":"e_1_2_6_39_1","article-title":"Opioid prescribing after surgery in the United States, Canada, and Sweden","volume":"2","author":"Ladha KS","year":"2019","journal-title":"Journal of the American Medical Association Network Open"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08338-9"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05016-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2018.10.003"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.06.013"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.09.019"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01215-y"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6078-3"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.4.344"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-4006-8"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004240"},{"key":"e_1_2_6_51_1","first-page":"1083","article-title":"Risks of developing persistent opioid use after major surgery","volume":"151","author":"Soneji N","year":"2016","journal-title":"Journal of the American Medical Association Surgery"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-022-00359-z"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.13619"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.02.030"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4844-y"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001029"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101324"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz260"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:27:48Z","timestamp":1761679668000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/anae.16055"],"URL":"https:\/\/doi.org\/10.1111\/anae.16055","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"assertion":[{"value":"2023-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}