{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:10:07Z","timestamp":1789035007430,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Postoperative nausea or vomiting occurs in up to 40% in patients with multiple risk factors, despite prophylaxis. Olanzapine is an antipsychotic drug that is used to prevent nausea and vomiting in palliative care and to treat chemotherapy\u2010induced nausea and vomiting. This study aimed to examine whether pre\u2010operative olanzapine, as a prophylactic anti\u2010emetic added to intra\u2010operative dexamethasone, ondansetron and total intravenous anaesthesia, reduced the incidence of postoperative nausea or vomiting. We performed a multiply\u2010blinded randomised controlled trial in patients aged 18\u201360\u2009years with cancer at high risk of postoperative nausea or vomiting (three or four risk factors according to the Apfel criteria) plus a previous history of chemotherapy\u2010induced nausea and vomiting. Patients were allocated at random to receive 10\u2009mg olanzapine or placebo orally 1\u2009h\u00a0before surgery in addition to a two\u2010drug regimen (dexamethasone and ondansetron) and propofol anaesthesia to prevent postoperative nausea or vomiting. The primary outcome was the incidence of postoperative nausea or vomiting in the first 24\u2009h\u00a0after surgery. In total, 100 patients were enrolled; 47 in the olanzapine group and 49 in the control group completed the study. The baseline characteristics of the groups were similar. The incidence of postoperative nausea or vomiting in the first 24\u2009h after surgery was lower in the olanzapine group (12\/47, 26%) than in the control group (31\/49, 63%) (p\u2009=\u20090.008, RR 0.40 (95%CI 0.21\u20130.79)). Adding pre\u2010operative oral olanzapine to intra\u2010operative dexamethasone and ondansetron was highly effective in reducing the risk of postoperative nausea or vomiting in the first 24\u2009hours after surgery in patients with a previous history of chemotherapy\u2010induced nausea and vomiting and at least three Apfel risk factors for postoperative nausea or vomiting.<\/jats:p>","DOI":"10.1111\/anae.16081","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:43:01Z","timestamp":1689331381000},"page":"1206-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Olanzapine as an add\u2010on, pre\u2010operative anti\u2010emetic drug for postoperative nausea or vomiting: a randomised controlled trial"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-8718","authenticated-orcid":false,"given":"T. R.","family":"Grigio","sequence":"first","affiliation":[{"name":"Postgraduate Program of Anesthesiology, Surgical Sciences and Perioperative Medicine Faculdade de Medicina da Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"},{"name":"Department of Anesthesiology, Pain Center University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-9043","authenticated-orcid":false,"given":"H.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain Center University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-508X","authenticated-orcid":false,"given":"J. V. B.","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-4290","authenticated-orcid":false,"given":"A.","family":"Slullitel","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Anesthesiology, Surgical Sciences and Perioperative Medicine Faculdade de Medicina da Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-3903","authenticated-orcid":false,"given":"A. P.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain Center University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-9083","authenticated-orcid":false,"given":"A. M.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Anesthesiology, Surgical Sciences and Perioperative Medicine Faculdade de Medicina da Universidade de S\u00e3o Paulo (USP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12552"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15295"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13064"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.02.017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003990"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003286"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460801.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep370"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.10.1233"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S113216"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.11.033"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.08.04"},{"key":"e_1_2_6_17_1","volume-title":"Olanzapine","author":"Thomas K","year":"2022"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0378"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937030-00001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-020-00559-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032196"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2013.01.002"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:07:17Z","timestamp":1761674837000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/anae.16081"],"URL":"https:\/\/doi.org\/10.1111\/anae.16081","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]},"assertion":[{"value":"2023-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}