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The peri\u2010operative period offers a unique opportunity to support patients to stop tobacco smoking, avoid complications and improve long\u2010term health. This systematic review provides an up\u2010to\u2010date summary of the evidence for tobacco cessation interventions in surgical patients. We conducted a systematic search of randomised controlled trials of tobacco cessation interventions in the peri\u2010operative period. Quantitative synthesis of the abstinence outcomes data was by random\u2010effects meta\u2010analysis. The primary outcome of the meta\u2010analysis was abstinence at the time of surgery, and the secondary outcome was abstinence at 12\u2009months. Thirty\u2010eight studies are included in the review (7310 randomised participants) and 26 studies are included in the meta\u2010analysis (5969 randomised participants). Studies were pooled for subgroup analysis in two ways: by the timing of intervention delivery within the peri\u2010operative period and by the intensity of the intervention protocol. We judged the quality of evidence as moderate, reflecting the degree of heterogeneity and the high risk of bias. Overall, peri\u2010operative tobacco cessation interventions increased successful abstinence both at the time of surgery, risk ratio (95%CI) 1.48 (1.20\u20131.83), number needed to treat 7; and 12\u2009months after surgery, risk ratio (95%CI) 1.62 (1.29\u20132.03), number needed to treat 9. More work is needed to inform the design and optimal delivery of interventions that are acceptable to patients and that can be incorporated into contemporary elective and urgent surgical pathways. Future trials should use standardised outcome measures.<\/jats:p>","DOI":"10.1111\/anae.16120","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:36:11Z","timestamp":1693564571000},"page":"1393-1408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Peri\u2010operative tobacco cessation interventions: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-0079","authenticated-orcid":false,"given":"S.","family":"Harrogate","sequence":"first","affiliation":[{"name":"Elizabeth Blackwell Institute University of Bristol  Bristol UK"},{"name":"Department of Anaesthesia, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Isted","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kunst","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, King's College London  London UK"},{"name":"Department of Anaesthesia, King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University Hospitals Bristol and Weston NHS Foundation Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rudd","sequence":"additional","affiliation":[{"name":"North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hinchliffe","sequence":"additional","affiliation":[{"name":"Department of Translational Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Department of Vascular Services, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mouton","sequence":"additional","affiliation":[{"name":"Department of Translational Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Department of Anaesthesia, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Office for Health Improvement and Disparities.The Khan review: making smoking obsolete.2022.https:\/\/www.gov.uk\/government\/publications\/the\u2010khan\u2010review\u2010making\u2010smoking\u2010obsolete(accessed 04\/08\/2023)."},{"key":"e_1_2_6_3_1","unstructured":"Office for National Statistics.Adult smoking habits in the UK: 2019.2020.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/healthandlifeexpectancies\/bulletins\/adultsmokinghabitsingreatbritain\/2019(accessed 04\/08\/2023)."},{"key":"e_1_2_6_4_1","unstructured":"Action on Smoking and Health. 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