{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:13:44Z","timestamp":1791728024845,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT170100363"],"award-info":[{"award-number":["FT170100363"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1122455"],"award-info":[{"award-number":["GNT1122455"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1185777"],"award-info":[{"award-number":["GNT1185777"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["VG104674"],"award-info":[{"award-number":["VG104674"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["NHF105666"],"award-info":[{"award-number":["NHF105666"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cardiac surgery requiring cardiopulmonary bypass is associated with postoperative acute kidney injury and neurocognitive disorders, including delirium. Intra\u2010operative inflammation and\/or impaired tissue perfusion\/oxygenation are thought to be contributors to these outcomes. It has been hypothesised that these problems may be ameliorated by the highly selective \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u2010agonist, dexmedetomidine. We tested the effects of dexmedetomidine on renal and cerebral microcirculatory tissue perfusion, oxygenation and histology in a clinically relevant ovine model. Sixteen sheep were studied while conscious, after induction of anaesthesia and during 2\u2009h of cardiopulmonary bypass. Eight sheep were allocated randomly to receive an intravenous infusion of dexmedetomidine (0.4\u20130.8\u2009\u03bcg.kg\n                    <jats:sup>\u20101<\/jats:sup>\n                    .h\n                    <jats:sup>\u20101<\/jats:sup>\n                    ) from induction of anaesthesia to the end of cardiopulmonary bypass, and eight to receive an equivalent volume of matched placebo (0.9% sodium chloride). Commencement of cardiopulmonary bypass decreased renal medullary tissue oxygenation in the placebo group (mean (95%CI) 5.96 (4.24\u20137.23) to 1.56 (0.84\u20132.09) kPa, p\u2009=\u20090.001), with similar hypoxic levels observed in the dexmedetomidine group (6.33 (5.33\u20137.07) to 1.51 (0.33\u20132.39) kPa, p\u2009=\u20090.002). While no differences in kidney function (i.e. reduced creatinine clearance) were evident, a greater incidence of histological renal tubular injury was observed in sheep receiving dexmedetomidine (7\/8 sheep) compared with placebo (2\/8 sheep), p\u2009=\u20090.041. Graded on a semi\u2010quantitative scale (0\u20133), median (IQR [range]) severity of histological renal tubular injury was higher in the dexmedetomidine group compared with placebo (1.5 (1\u20132 [0\u20133]) vs. 0 (0\u20130.3 [0\u20131]) respectively, p\u2009=\u20090.013). There was no difference in cerebral tissue microglial activation (neuroinflammation) between the groups. Dexmedetomidine did not reduce renal medullary hypoxia or cerebral neuroinflammation in sheep undergoing cardiopulmonary bypass.\n                  <\/jats:p>","DOI":"10.1111\/anae.16152","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T01:01:51Z","timestamp":1698282111000},"page":"1481-1492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of dexmedetomidine on kidney and brain tissue microcirculation and histology in ovine cardiopulmonary bypass: a randomised controlled trial"],"prefix":"10.1111","volume":"78","author":[{"given":"A. H.","family":"Jufar","sequence":"first","affiliation":[{"name":"Cardiovascular Disease Program Biomedicine Discovery Institute and Department of Physiology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. N.","family":"May","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Critical Care Unit Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Booth","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Critical Care Unit Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program Biomedicine Discovery Institute and Department of Physiology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Marino","sequence":"additional","affiliation":[{"name":"Cell Saving and Perfusion Resources  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Birchall","sequence":"additional","affiliation":[{"name":"Neurohistology Laboratory Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Hood","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Critical Care Unit Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Critical Care University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Central Clinical School and NHMRC Clinical Trials Centre Faculty of Medicine and Health University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Yao","sequence":"additional","affiliation":[{"name":"Cardiovascular Neuroscience Laboratory Department of Anatomy and Physiology University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ortega\u2010Bernal","sequence":"additional","affiliation":[{"name":"Cardiovascular Neuroscience Laboratory Department of Anatomy and Physiology University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Skene","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Austin Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Department of Critical Care University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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