{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:57:50Z","timestamp":1789657070439,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013631","name":"Patient Safety Translational Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001297","name":"Royal College of Anaesthetists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Appendicectomy is a common procedure in children with a low risk of mortality, however, complication rates and risk factors are largely unknown. This study aimed to characterise the incidence and epidemiology of postoperative complications in children undergoing appendicectomy in the UK. This multicentre prospective observational cohort study, which included children aged 1\u201316 y who underwent surgery for suspected appendicitis, was conducted between November 2019 and January 2022. The primary outcome was 30\u2010day postoperative morbidity. Data collected included: patient characteristics; comorbidities; and physiological status. Multivariable regression analysis was used to identify independent risk factors for poor outcomes. Data from 2799 children recruited from 80 hospitals were analysed, of which 185 (7%) developed postoperative complications. Children from black and \u2018other\u2019 minority ethnic groups were at significantly higher risk of poor outcomes: OR (95%CI) 4.13 (1.87\u20139.08), p\u2009&lt;\u20090.001 and 2.08 (1.12\u20133.87), p\u2009=\u20090.021, respectively. This finding was independent of socio\u2010economic status and type of appendicitis found on histology. Other risk factors for complications included: ASA physical status \u2265\u20093 (OR (95%CI) 4.05 (1.70\u20139.67), p\u2009=\u20090.002); raised C\u2010reactive protein (OR 95%CI 1.01 (1.00\u20131.01), p\u2009&lt;\u20090.001); pyrexia (OR (95%CI) 1.77(1.20\u20132.63), p\u2009=\u20090.004); and peri\u2010operative oxygen supplementation (OR (95%CI) 4.20 (1.44\u201312.24), p\u2009=\u20090.009). In the UK NHS, which is a universally accessible healthcare system, ethnicity, but not socio\u2010economic status, was associated with an increased risk of postoperative complications in children having surgery for acute appendicitis. Further evaluations and interventions are required to address this health inequality in keeping with NHS and international priorities.<\/jats:p>","DOI":"10.1111\/anae.16184","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T18:01:16Z","timestamp":1708624876000},"page":"524-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors for complications after emergency surgery for paediatric appendicitis: a national prospective observational cohort study"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-0202","authenticated-orcid":false,"given":"L. A.","family":"Sogbodjor","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine Great Ormond Street Hospital NHS Foundation Trust  London UK"},{"name":"Centre for Research and Improvement Royal College of Anaesthetists  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Razavi","sequence":"additional","affiliation":[{"name":"Centre for Research and Improvement Royal College of Anaesthetists  London UK"},{"name":"Department of Anaesthesia Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Research and Improvement Royal College of Anaesthetists  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Selman","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. Pinto","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centre for Peri\u2010operative Medicine, Research Department for Targeted Intervention UCL Division of Surgery and Interventional Science  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Davenport","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery King's College London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CASAP investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Moonesinghe","sequence":"additional","affiliation":[{"name":"Centre for Peri\u2010operative Medicine, Research Department for Targeted Intervention UCL Division of Surgery and Interventional Science  London UK"},{"name":"Central London National Institute for Health Research Patient Safety Research Collaboration  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"KennySE.NHS England and NHS Improvement; Getting It Right First Time: Paediatric Surgery GIRFT Programme National Specialty Report.2021.https:\/\/gettingitrightfirsttime.co.uk\/wp\u2010content\/uploads\/2022\/09\/PaediatricSurgeryReport\u2010Sept21w.pdf(accessed 06\/09\/2023)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1703"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001099"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000246"},{"key":"e_1_2_6_6_1","article-title":"Quantifying the burden of interhospital cost variation in pediatric surgery implications for the prioritization of comparative effectiveness research","volume":"171","author":"Cameron DB","year":"2017","journal-title":"Journal of the American Medical Association: Pediatrics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.12.020"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.02.074"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11298"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13181"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.10.032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000707"},{"key":"e_1_2_6_13_1","unstructured":"Office for National Statistics.Ethnic group by age and sex England and Wales: census 2021.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/culturalidentity\/ethnicity\/articles\/ethnicgroupbyageandsexenglandandwales\/census2021#glossary(accessed 02\/02\/2023)."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15858"},{"key":"e_1_2_6_15_1","unstructured":"Scottish Index of Multiple Deprivation 2020.https:\/\/simd.scot\/#\/simd2020\/BTTTFTT\/8\/\u20103.9999\/55.9000\/(accessed 01\/08\/2023)."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13923"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1367493511408632"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-40"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.09.027"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3268567"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-4113"},{"key":"e_1_2_6_22_1","article-title":"Association of race and family socioeconomic status with pediatric postoperative mortality","volume":"5","author":"Willer BL","year":"2022","journal-title":"Journal of the American Medical Association: Network Open"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.022"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.089"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.683607"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.600320"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.12722"},{"key":"e_1_2_6_28_1","first-page":"1674","article-title":"What has changed in children's appendicitis during the COVID\u201019 pandemic?","volume":"28","author":"Ayy\u0131ld\u0131z HN","year":"2022","journal-title":"Ulusal Travma ve Acil Cerrahi Dergisi"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.03.029"},{"key":"e_1_2_6_30_1","unstructured":"NHS England.Core20PLUS5 \u2013 An approach to reducing health inequalities for children and young people.https:\/\/www.england.nhs.uk\/about\/equality\/equality\u2010hub\/national\u2010healthcare\u2010inequalities\u2010improvement\u2010programme\/core20plus5\/core20plus5\u2010cyp\/(accessed 21\/05\/2023)."},{"key":"e_1_2_6_31_1","unstructured":"The King's Fund.Ethnic health inequalities and the NHS driving progress in a changing system.2021.https:\/\/www.nhsrho.org\/wp\u2010content\/uploads\/2023\/05\/Ethnic\u2010Health\u2010Inequalities\u2010Kings\u2010Fund\u2010Report.pdf(accessed 06\/09\/2023)."},{"key":"e_1_2_6_32_1","unstructured":"The King's Fund.The health of people from ethnic minority groups in England.2021.https:\/\/www.kingsfund.org.uk\/publications\/health\u2010people\u2010ethnic\u2010minority\u2010groups\u2010england#Materna(accessed 04\/05\/2023)."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2614-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.31486\/toj.19.0116"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101428"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004707"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:04:00Z","timestamp":1761699840000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/anae.16184"],"URL":"https:\/\/doi.org\/10.1111\/anae.16184","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,22]]},"assertion":[{"value":"2023-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}