{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:53:42Z","timestamp":1792587222246,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hip fracture is a common serious injury among older adults, yet the management of hip fractures for patients taking direct oral anticoagulants remains inconsistent worldwide. Drawing from a synthesis of available evidence and expert opinion, best practice approaches for managing patients with a hip fracture and who are taking direct oral anticoagulants pre\u2010operatively were considered by a working group of the Fragility Fracture Network Hip Fracture Audit Special Interest Group. The literature and related clinical guidelines were reviewed and a two\u2010round modified Delphi study was conducted with a panel of experts from 16 countries and involved seven clinical specialities. Four consensus statements were achieved: peripheral nerve blocks can reasonably be performed on presentation for patients with hip fracture who are receiving direct oral anticoagulants; hip fracture surgery can reasonably be performed for patients taking direct oral anticoagulants &lt;\u200936\u2009h from last dose; general anaesthesia could reasonably be administered for patients with hip fracture and who are taking direct oral anticoagulants &lt;\u200936\u2009h from last dose (assuming eGFR &gt;\u200960\u2009ml.min\n                    <jats:sup>\u20101<\/jats:sup>\n                    .1.73\u2009m\n                    <jats:sup>\u20102<\/jats:sup>\n                    ); and it is generally reasonable to consider recommencing direct oral anticoagulants (considering blood loss and haemoglobin) &lt;\u200948\u2009h after hip fracture surgery. No consensus was achieved regarding timing of spinal anaesthesia. The consensus statements were developed to aid clinicians in their decision\u2010making and to reduce practice variations in the management of patients with hip fracture and who are taking direct oral anticoagulants. Each statement will need to be considered specific to each individual patient's treatment.\n                  <\/jats:p>","DOI":"10.1111\/anae.16226","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:30:56Z","timestamp":1707283856000},"page":"627-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Principles for management of hip fracture for older adults taking direct oral anticoagulants: an international consensus statement"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-1761","authenticated-orcid":false,"given":"R. J.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Australian Institute of Health Innovation Macquarie University  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-955X","authenticated-orcid":false,"given":"S.","family":"Wijekulasuriya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Huddersfield Royal Infirmary  Huddersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mayor","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. K.","family":"Borges","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Tonelli","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre  Porto Alegre Brazil"},{"name":"Department of Orthopaedic Surgery and Biomedical Engineering University of Michigan  Ann Arbour MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Fiona Stanley Fremantle Hospitals Group  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-1825","authenticated-orcid":false,"given":"H.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Fiona Stanley Fremantle Hospitals Group  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Fragility Fracture Network Hip Fracture Audit Special Interest\u00a0Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15291"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000763"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy136"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000683"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.07.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.21.01476"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001600"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.260"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0332-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17606"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30058-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.092220"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046175"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B9.BJJ-2019-0295.R1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32098-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1738"},{"key":"e_1_2_10_18_1","unstructured":"National Institute for Health and Care Excellence.Hip fracture: management. [CG124].2011.https:\/\/www.nice.org.uk\/guidance\/cg124."},{"key":"e_1_2_10_19_1","unstructured":"Australian and New Zealand Hip Fracture Registry Steering Group.Australian and New Zealand guideline for hip fracture care: Improving outcomes in hip fracture management of adults.2014."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-14-00432"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.967299"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208824"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151459318764150"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2158"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-05904-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4786-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.04.040"},{"key":"e_1_2_10_28_1","first-page":"252","article-title":"Surgical treatment of hip fractures: factors influencing mortality","volume":"17","author":"Dailiana Z","year":"2013","journal-title":"Hippokratia"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.5.190071"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2020.08.005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2019-111317"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-01937-8"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.103B2.BJJ-2020-0583.R2"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14225"},{"key":"e_1_2_10_35_1","unstructured":"WikiGuidelines.Wikiguidelines charter.2022.https:\/\/www.wikiguidelines.com\/charter."},{"key":"e_1_2_10_36_1","unstructured":"Kidney Disease Improving Global Outcomes. Consensus Conference on Nomenclature for kidney Function and Disease. Amsterdam. 2019.https:\/\/kdigo.org\/conferences\/nomenclature."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1054\/nedt.2001.0573"},{"key":"e_1_2_10_38_1","first-page":"590","article-title":"Safety of femoral nerve blockage for hip fractures in adult patients treated with anti\u2010xa direct oral anticoagulants: a pilot study","volume":"23","author":"Dayan RR","year":"2021","journal-title":"Israel Medical Association Journal"},{"key":"e_1_2_10_39_1","article-title":"Peripheral nerve blocks for hip fractures in adults","volume":"11","author":"Guay J","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000002251"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58030379"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/OI9.0000000000000089"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.11.005"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.04.022"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.5301\/HIP.2011.8842"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120700019841351"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151459320944854"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-04170-x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20190321-02"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.12.036"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/14604086231165567"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.10.033"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02261-x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/21514593221088405"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001146"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020625"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072200"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.09.017"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001329"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-020-00319-w"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013473"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22647"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13415"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2022.102080"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-019-01954-2"},{"key":"e_1_2_10_66_1","volume-title":"A multicentre prospective service evaluation of timing of surgery in older hip and femoral fracture patients on oral anticoagulants","author":"Alanie M","year":"2023"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:04:17Z","timestamp":1761674657000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/anae.16226"],"URL":"https:\/\/doi.org\/10.1111\/anae.16226","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}