{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:03Z","timestamp":1787013843224,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004463","name":"Bupa Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peri\u2010operative neurocognitive disorders are one of the most common complications affecting older adults after anaesthesia and surgery. It is not clear how exposure to surgery and anaesthesia contributes to the prevalence of long\u2010term neurocognitive disorders. This study aimed to report the prevalence of neurocognitive disorders, and explore pre\u2010operative factors associated with neurocognitive disorders 5\u2009years after elective orthopaedic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, 5\u2010year longitudinal, cohort study was performed recruiting patients (aged \u2265\u200960\u2009y) undergoing elective orthopaedic surgery and a contemporaneous non\u2010surgical control group. Neurocognitive disorder was evaluated and classified at baseline and 5\u2010year review incorporating: self\u2010 and informant\u2010reported cognition; functional participation; and performance on neuropsychological tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recruitment at 5\u2010year follow\u2010up included 195 patients and 21 control participants. In the patient cohort the prevalence of neurocognitive disorder was 38.1% (n\u2009=\u200975), with 61 (30.1%) meeting the criteria for mild neurocognitive disorder and 14 (7.1%) for major neurocognitive disorder. At 5\u2010year follow\u2010up, 121 (61.4%) patients were classified with a neurocognitive disorder, with 88 (44.7%) characterised with mild neurocognitive disorder and 33 (16.8%) with major neurocognitive disorder. Age (odds ratio (95%CI) 1.07 (1.02\u20131.13); p\u2009=\u20090.01) and baseline cognitive impairment (odds ratio (95%CI) 2.1 (1.06\u20134.15); p\u2009=\u20090.03) were significant predictors of neurocognitive disorder 5\u2009years after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than half of older adult patients had some form of neurocognitive disorder 5\u2009years after elective orthopaedic surgery. Surgery and anaesthesia may be associated with the trajectory of cognitive decline in at\u2010risk older adults, including those with pre\u2010operative cognitive impairment. Cognitive screening should be factored into pre\u2010operative assessments of older adults to inform subsequent care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16365","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T11:29:38Z","timestamp":1720610978000},"page":"1053-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of neurocognitive disorders 5\u2009years after elective orthopaedic surgery"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-2494","authenticated-orcid":false,"given":"Kelly J.","family":"Atkins","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Weill Cornell Medicine  New York NY USA"},{"name":"Department of Critical Care, Melbourne Medical School University of Melbourne  Melbourne VIC 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