{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:11:59Z","timestamp":1787134319777,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While evidence from preclinical and observational cohort studies have suggested potential disparities in tumour behaviour associated with the choice of intra\u2010operative anaesthetics, clinical evidence of tumour recurrence and metastasis remains inconclusive. We aimed to compare the impact of intra\u2010operative anaesthesia on oncologic outcomes following hepatectomy for hepatocellular carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients scheduled for elective hepatectomy for hepatocellular carcinoma were assigned randomly (1:1) to either propofol\u2010based total intravenous anaesthesia or sevoflurane\u2010based inhalational anaesthesia. For recurrence\u2010free survival, overall survival, intrahepatic recurrence\u2010free survival and extrahepatic recurrence\u2010free survival, the survival curves of the two groups were estimated using the Kaplan\u2013Meier method and compared with the log\u2010rank test. The primary outcome was one\u2010year recurrence\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 536 patients enrolled, primary analysis comprised 228 and 226 patients in the total intravenous anaesthesia and sevoflurane\u2010based inhalational anaesthesia groups, respectively. The probability of recurrence\u2010free survival at one year was 79.1% (47 events) and 77.7% (50 events) in the total intravenous anaesthesia and sevoflurane\u2010based inhalational anaesthesia groups, respectively (adjusted hazard ratio 1.04, 95%CI 0.72\u20131.52). The probability of intrahepatic and extrahepatic recurrence\u2010free survival, as well as overall survival at one year, was not significantly different between total intravenous anaesthesia and sevoflurane\u2010based inhalational anaesthesia: 81.3% (42 events) vs. 81.7% (41 events); 91.5% (19 events) vs. 88.8% (25 events); 99.1% (2 events) vs. 100.0% (no event), respectively. Subgroup analyses revealed that in patients undergoing open hepatectomy, total intravenous anaesthesia was associated with a significantly lower hazard of tumour recurrence or death (hazard ratio 0.49, 95%CI 0.25\u20130.95, p\u2009=\u20090.034), while in patients undergoing laparoscopic surgery, no significant difference was observed (hazard ratio 1.14, 95%CI 0.73\u20131.80, p\u2009=\u20090.558).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Intra\u2010operative anaesthesia technique did not affect postoperative recurrence and overall survival in patients with hepatocellular carcinoma undergoing hepatectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16488","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:02:02Z","timestamp":1736308922000},"page":"366-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recurrence\u2010free survival after hepatectomy using propofol\u2010based total intravenous anaesthesia and sevoflurane\u2010based inhalational anaesthesia: a randomised controlled study"],"prefix":"10.1111","volume":"80","author":[{"given":"Ji\u2010Hye","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Samsung Medical Center Sungkyunkwan University School of 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