{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:53:49Z","timestamp":1788152029168,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High\u2010flow nasal oxygenation has been shown to improve oxygenation during induction of anaesthesia in parturients who are not obese. However, data on the efficacy of high\u2010flow nasal oxygen in parturients living with obesity are lacking. This study investigated the effects of high\u2010flow nasal oxygenation on pre\u2010oxygenation and apnoea oxygenation during tracheal intubation in parturients living with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, randomised clinical trial was conducted at two tertiary hospitals and included parturients with BMI &gt;\u200930\u2009kg.m\n                      <jats:sup>\u20102<\/jats:sup>\n                      undergoing scheduled caesarean delivery under general anaesthesia. Parturients were allocated randomly to standard facemask or high\u2010flow nasal oxygen groups (oxygen flow rates 10\u2009l.min\n                      <jats:sup>\u20101<\/jats:sup>\n                      and 50\u2009l.min\n                      <jats:sup>\u20101<\/jats:sup>\n                      , respectively). The primary outcome measure was arterial partial pressure of oxygen after 3\u2009min of pre\u2010oxygenation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>54 patients completed the study. The arterial partial pressure of oxygen after 3\u2009min of pre\u2010oxygenation was significantly lower in parturients allocated to the standard facemask group compared with those allocated to the high\u2010flow nasal oxygen group (mean (SD) 40.1 (8.9) kPa vs. 53.8 (9.7) kPa, p\u2009&lt;\u20090.001). End\u2010tidal oxygen concentration on commencing ventilation was also lower in parturients allocated to the standard facemask group compared with those allocated to the high flow\u2010nasal oxygen group (mean (SD) 78.3 (5.38)% vs. 86.2 (5.10)%, p\u2009&lt;\u20090.001). The arterial partial pressure of carbon dioxide post tracheal intubation and fetal outcomes were similar in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Pre\u2010oxygenation using high\u2010flow nasal oxygenation provided a higher arterial partial pressure of oxygen and end\u2010tidal oxygen concentration during general anaesthesia induction than standard facemask oxygenation in parturients living with obesity; however, the differences were not clinically meaningful. High\u2010flow nasal oxygenation may be considered as an alternative option for pre\u2010oxygenation during rapid sequence induction in parturients living with obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16492","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T20:48:02Z","timestamp":1732654082000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of high\u2010flow nasal oxygenation during induction of general anaesthesia in parturients living with obesity: a two\u2010centre, prospective, randomised clinical trial"],"prefix":"10.1111","volume":"80","author":[{"given":"Shuang\u2010Qiong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Feng","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Quanzhou Women's and Children's Hospital  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Geisinger Clinic  Danville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal\u2010Fetal Medicine and 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