{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:15:39Z","timestamp":1782922539927,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014262","name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie et de R\u00e9animation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Iron deficiency, with or without anaemia, is common during the peri\u2010operative period. It has been hypothesised that pre\u2010operative iron deficiency is associated with an increased incidence of postoperative infection. We designed the CARIPO prospective observational study to assess the incidence of postoperative infection in patients with and without iron deficiency undergoing a variety of major surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010centre study in a tertiary, university\u2010affiliated hospital in France. Iron deficiency was defined as a ferritin &lt;\u2009100\u2009\u03bcg.l\n                      <jats:sup>\u20101<\/jats:sup>\n                      or &lt;\u2009300\u2009\u03bcg.l\n                      <jats:sup>\u20101<\/jats:sup>\n                      with a transferrin saturation &lt;\u200920%. The primary outcome was incidence of any postoperative infectious complication measured at 90\u2009days after surgery. Secondary endpoints included the incidence of individual infectious complications: surgical site infection; bacteraemia; pneumonia; urinary tract infection; peripheral line\u2010associated bacterial infection; and all\u2010cause postoperative complication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recruited 390 patients. Of these, 170 (44%) had pre\u2010operative iron deficiency and 220 (66%) were iron replete; 27 (16%) patients in the iron deficient group developed a postoperative infection compared with 26 (12%) in the iron replete group (p\u2009=\u20090.25). Surgical site infections occurred in 11 (7%) iron deficient patients and 3 (1%) iron replete patients (p\u2009=\u20090.01). Other types of infectious complication and all\u2010cause postoperative complication were similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Iron deficiency was not associated with a higher rate of postoperative infection relative to an iron replete state. While iron deficiency was associated with a higher rate of surgical site infection, this result is hypothesis\u2010generating, and further prospective studies are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16498","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:03:23Z","timestamp":1734051803000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between pre\u2010operative iron deficiency and postoperative infection in patients undergoing major surgery (\n                    <scp>CARIPO<\/scp>\n                    ): a prospective observational study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-1997","authenticated-orcid":false,"given":"Ma\u00ebva","family":"Campfort","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"},{"name":"INSERM UMR 1083, MitoVasc Laboratory (Mitochondrial and Cardiovascular Physiopathology)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Perrault","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Blanchard\u2010Daguet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"},{"name":"INSERM UMR 1083, MitoVasc Laboratory (Mitochondrial and Cardiovascular Physiopathology)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Rineau","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"},{"name":"INSERM UMR 1083, MitoVasc Laboratory (Mitochondrial and Cardiovascular Physiopathology)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigismond","family":"Lasocki","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"},{"name":"INSERM UMR 1083, MitoVasc Laboratory (Mitochondrial and Cardiovascular Physiopathology)  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0904"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.03.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106136"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.9763"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.07.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13873"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.10.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.09.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2012.07.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105320\u20108"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2022.101192"},{"key":"e_1_2_6_14_1","unstructured":"World Health Organization.Nutritional anaemias. Report of a WHO scientific group. Geneva. 1968: 5\u201337.https:\/\/iris.who.int\/bitstream\/handle\/10665\/40707\/WHO_TRS_405.pdf?sequence=1&isAllowed=y."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010199908000\u201000050"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2016.07.006"},{"key":"e_1_2_6_17_1","unstructured":"Centers for Disease Control and Prevention.Bloodstream Infections 2024.https:\/\/www.cdc.gov\/ncidod\/dhqp\/bsi.html(accessed 10\/11\/2024)."},{"key":"e_1_2_6_18_1","unstructured":"Centers for Disease Control and Prevention.Urinary Tract Infection. 2024.https:\/\/www.cdc.gov\/ncidod\/dhqp\/uti.html(accessed 10\/11\/2024)."},{"key":"e_1_2_6_19_1","unstructured":"Centers for Disease Control and Prevention.Pneumonia. 2024.\u00a0https:\/\/www.cdc.gov\/ncidod\/dhqp\/pneumonia.html(accessed 10\/11\/2024)."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12225"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2024.101404"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61381\u20100"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13693"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2024.01.007"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14303"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(22)00142\u20109"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005161"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012003282"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31539\u20107"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(16)30078\u20103"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.616S"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(90)92013\u20108"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.11.864"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098\u2010010\u20100120\u20103"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:48:06Z","timestamp":1761680886000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/anae.16498"],"URL":"https:\/\/doi.org\/10.1111\/anae.16498","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}