{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:02:26Z","timestamp":1775775746698,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>General anaesthesia and regional anaesthesia are used for hip and knee arthroplasty but their impact on long\u2010term outcomes remains unclear. This study aimed to compare one\u2010year clinical outcomes and healthcare utilisation in patients receiving general or regional anaesthesia for hip or knee arthroplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the TriNetX Global Collaborative Network, we conducted a retrospective analysis of 247,142 patients aged 40\u201390\u2009y who underwent hip or knee arthroplasty between 2010 and 2023. After propensity score matching, 12,558 patients were included in the general anaesthesia and regional anaesthesia cohorts. The primary outcome was one\u2010year all\u2010cause mortality. Secondary outcomes included one\u2010year incidence of dementia; cerebral infarction; pneumonia; major depression; care provider dependency; and readmission rates. Subgroup analyses according to sex, age (40\u201370\u2009y vs. &gt;\u200970\u2009y) and timeframe (2010\u20132016 vs. 2017\u20132023) were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference in one\u2010year mortality (hazard ratio 1.12, 95%CI 0.89\u20131.41, p\u2009=\u20090.322). General anaesthesia was associated with a lower incidence of major depression (hazard ratio 0.82, 95%CI 0.70\u20130.97, p\u2009=\u20090.021) and care provider dependency (hazard ratio 0.47, 95%CI 0.38\u20130.58, p\u2009&lt;\u20090.001), but higher readmission rates (hazard ratio 1.22, 95%CI 1.16\u20131.29, p\u2009&lt;\u20090.001) than regional anaesthesia. Subgroup analysis revealed that patient characteristics including sex and age, as well as evolving peri\u2010operative care practices over time, may influence the comparative outcomes of general and regional anaesthesia in patients undergoing elective hip or knee arthroplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Although general anaesthesia and regional anaesthesia showed comparable one\u2010year mortality, general anaesthesia was associated with lower risks of major depression and care provider dependency but higher readmission rates than regional anaesthesia. These findings suggest that the choice of anaesthesia may have important implications for long\u2010term outcomes beyond mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16511","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:50:11Z","timestamp":1734054611000},"page":"488-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of general vs. regional anaesthesia on one\u2010year clinical outcomes and healthcare utilisation after lower limb arthroplasty: a retrospective study"],"prefix":"10.1111","volume":"80","author":[{"given":"Chun\u2010Ning","family":"Ho","sequence":"first","affiliation":[{"name":"School of Medicine College of Medicine, National Sun Yat\u2010sen University  Kaohsiung City Taiwan"},{"name":"Department of Anesthesiology Chi Mei Medical Center  Tainan City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, E\u2010Da Hospital I\u2010Shou University  Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Chuan","family":"Hung","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine, National Sun Yat\u2010sen University  Kaohsiung City Taiwan"},{"name":"Department of Anesthesiology Chi Mei Medical Center  Tainan City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Chi Mei Medical Center  Tainan City Taiwan"},{"name":"The Department of Occupational Therapy Shu\u2010Zen Junior College of Medicine and Management  Kaohsiung City 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