{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:18:25Z","timestamp":1784715505504,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intravenous lidocaine is a promising complementary strategy for sedation during surgical procedures. We performed a systematic review and meta\u2010analysis to compare intravenous lidocaine with placebo as an adjuvant to propofol\u2010based sedation in patients undergoing colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, Embase and Cochrane databases for randomised controlled trials comparing sedation with propofol and lidocaine vs. propofol and placebo in patients undergoing colonoscopy. The primary outcome was total propofol dose. A random\u2010effects model was used to estimate the mean differences and risk ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included eight trials with 520 patients. Compared with placebo, intravenous lidocaine reduced propofol consumption during the procedure (mean difference (95%CI): \u201042.93\u2009mg (\u201062.89 to \u201022.97)); shortened awakening time (mean difference (95%CI): \u20103.38\u2009minutes (\u20105.92 to \u20100.84)); reduced post\u2010procedural pain scores (mean difference (95%CI): \u20101.38 (\u20102.72 to \u20100.04)); and increased patient satisfaction scores (mean difference (95%CI): 0.50 (0.30 to 0.70)). There were no significant differences between the groups in procedure duration; endoscopist satisfaction scores; and risk of hypoxia or hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In patients undergoing colonoscopy, the addition of intravenous lidocaine to propofol\u2010based sedation reduced propofol consumption, shortened awakening time, mitigated post\u2010procedural pain and enhanced patient satisfaction compared with placebo. Although the findings are statistically significant, clinical relevance and cost\u2010effectiveness are unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16563","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T23:04:01Z","timestamp":1742339041000},"page":"694-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intravenous lidocaine with propofol\u2010based sedation for colonoscopy: a systematic review and meta\u2010analysis with trial sequential analysis"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-4701","authenticated-orcid":false,"given":"Eduardo C.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Medicine Evangelical University of Goi\u00e1s  An\u00e1polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-1098","authenticated-orcid":false,"given":"J\u00falia M.","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Department of Medicine Evangelical University of Goi\u00e1s  An\u00e1polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9121-6503","authenticated-orcid":false,"given":"Paulo F. E.","family":"Bertoldi","sequence":"additional","affiliation":[{"name":"Department of Medicine Pontifical Catholic University of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-9885","authenticated-orcid":false,"given":"Paula","family":"Santo","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging and Specialized Diagnosis Unit University Hospital of Federal University of S\u00e3o Carlos  S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-9167","authenticated-orcid":false,"given":"Stefano","family":"Baraldo","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-0708","authenticated-orcid":false,"given":"Ang\u00e9lica L.","family":"Nau","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Jaragu\u00e1 Hospital  Jaragu\u00e1 do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-4368","authenticated-orcid":false,"given":"Gilmara C.","family":"Meine","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Feevale University  Novo Hamburgo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.02.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2024.102315"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1379101"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S475749"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.47886"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375\u20109393.24.18203\u2010X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.07.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.2.151"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S408811"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.01.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.12.038"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.12.036"},{"key":"e_1_2_6_14_1","volume-title":"The burden of digestive diseases in the United States","author":"Ruhl C","year":"2008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102024\u2010332071"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938\u2010016\u20100089\u20108"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i3.610"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010020\u201006143\u20103"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330396"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.08.036"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010023\u201003589\u2010y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008455\u2010w"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010024\u201007300\u20107"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375\u20109393.24.17920\u20105"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.01.008"},{"key":"e_1_2_6_26_1","unstructured":"HigginsJ ThomasJ ChandlerJ et\u00a0al.Cochrane handbook for systematic reviews of interventions version 6.3.2022."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7568.597"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010021\u201001310\u20100"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.56126\/72.3.2"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010020\u201001049\u2010z"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.06.019"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S266062"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010022\u201001601\u2010z"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030670"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010021\u201001525\u20100"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_275_21"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2015.110"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200006000\u201000028"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2004.01.009"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.15444"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq189"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes097"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010229"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104886(67)90147\u20101"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001527"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaed\/mkw008"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2004.05.001"},{"key":"e_1_2_6_54_1","first-page":"994","volume-title":"Goldfrank's toxicologic emergencies","author":"Sztajnkrycer M","year":"2019"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259\u20101162.143110"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T16:04:50Z","timestamp":1761667490000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/anae.16563"],"URL":"https:\/\/doi.org\/10.1111\/anae.16563","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"2024-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}