{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:50:51Z","timestamp":1792029051719,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sepsis is a high burden syndrome associated with increased morbidity and mortality in both the acute and longer\u2010term phases of illness. Multiple treatment uncertainties remain that require resolution through high\u2010quality research. This study aimed to identify the top 10 research priorities for sepsis research in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a priority setting partnership study co\u2010produced by sepsis survivors, carers and clinicians. This included five stages: initiation of steering group formation and confirmation of the scope of the priority setting partnership; identification of clinical uncertainties through an electronic survey; analysis and verification of uncertainties; interim prioritisation to the top 25 ranked questions; and final prioritisation to determine the top 10 research priorities, using the nominal group technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our initial survey respondents comprised 447\/718 (62.3%) people who had survived sepsis, their friends and family members; 218\/718 (30.4%) clinicians; and 53\/718 (7.1%) multiple\/other roles who identified 53 distinct research uncertainties. Our interim prioritisation survey comprised 429\/941 (45.8%) people who had survived sepsis, their friends and family members; 431\/941 (46.0%) clinicians; and 73\/941 (8.2%) multiple\/other roles, with the top 25 ranked summary questions taken forwards for final prioritisation. From these, final workshop participants (n\u2009=\u200927) agreed a top 10 list of research priorities. Improved sepsis diagnosis; characterisation and management of the post\u2010sepsis syndrome; and non\u2010antibiotic treatment of sepsis were the top three priorities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We established priorities for sepsis research through a rigorous process of consensus involving sepsis survivors, carers and clinicians. These priorities will support future delivery of meaningful research to improve outcomes from sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anae.16634","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T18:00:28Z","timestamp":1749146428000},"page":"1190-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Top 10 research priorities for sepsis research determined by patients, carers and clinicians"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-6801","authenticated-orcid":false,"given":"Joanne","family":"McPeake","sequence":"first","affiliation":[{"name":"The Healthcare Improvement Studies Institute University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Ahmad","sequence":"additional","affiliation":[{"name":"The James Lind Alliance University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Bradley","sequence":"additional","affiliation":[{"name":"Patient Representative  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-3216","authenticated-orcid":false,"given":"Andrew Conway","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine University of Cambridge  Cambridge UK"},{"name":"John V Farman Intensive Care Unit, Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-0164","authenticated-orcid":false,"given":"Paul","family":"Dark","sequence":"additional","affiliation":[{"name":"Division of Immunology, Immunity to Infection and Respiratory Medicine Faculty of Biology, Medicine and Health, Critical Care Unit, Northern Care Alliance NHS Foundation Trust, Salford Care Organisation  Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Graham","sequence":"additional","affiliation":[{"name":"Sepsis Research (FEAT)  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Hall","sequence":"additional","affiliation":[{"name":"Patient Representative  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-9760","authenticated-orcid":false,"given":"Susan","family":"Moug","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Alexandra Hospital  Paisley UK"},{"name":"College of Medical, Veterinary, and Life Sciences, University of Glasgow  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Oakes","sequence":"additional","affiliation":[{"name":"Patient Representative  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Perry","sequence":"additional","affiliation":[{"name":"Patient Representative  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Stockley","sequence":"additional","affiliation":[{"name":"Eaglescliffe Medical Practice  Eaglescliffe UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Weaver","sequence":"additional","affiliation":[{"name":"Patient Representative  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-5497","authenticated-orcid":false,"given":"Bronwen","family":"Connolly","sequence":"additional","affiliation":[{"name":"Wellcome\u2010Wolfson Institute for Experimental Medicine, Queen's University Belfast  Belfast UK"},{"name":"Department of Physiotherapy The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-2779","authenticated-orcid":false,"given":"Nazir","family":"Lone","sequence":"additional","affiliation":[{"name":"The Usher Institute, University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"York Health Economics Consortium.The cost of sepsis care in the UK.2017.https:\/\/sepsistrust.org\/wp\u2010content\/uploads\/2024\/11\/YHEC\u2010Sepsis\u2010Report\u201017.02.17\u2010FINAL.pdf(accessed 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