{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:03Z","timestamp":1787013843279,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2023055"],"award-info":[{"award-number":["B2023055"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Video\u2010assisted thoracoscopic lung resection causes significant postoperative pain. We hypothesised that continuous erector spinae plane block would provide non\u2010inferior analgesia compared with a conventional opioid\u2010based regimen for this procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were allocated randomly to continuous erector spinae plane block (continuous infusion of 0.25% ropivacaine via perineural catheters (5\u2009ml.h\n                      <jats:sup>\u20101<\/jats:sup>\n                      ) combined with programmed intermittent bolus (10\u2009ml every 6\u2009h for the initial 24\u2009h)) or conventional opioid\u2010based regimen (continuous infusion of opioid (2\u2009\u03bcg.kg\n                      <jats:sup>\u20101<\/jats:sup>\n                      sufentanil and 16\u2009mg ondansetron diluted to 100\u2009ml with 0.9% normal saline) at 2\u2009ml.h\n                      <jats:sup>\u20101<\/jats:sup>\n                      for 48\u2009h). The primary outcome was overall analgesic efficacy with cough, quantified by the cumulative area under curve for the pain numeric rating scale scores, from post\u2010anaesthesia care unit discharge to 48\u2009h postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative area under curve for the pain numeric rating scale score in patients allocated to the continuous erector spinae plane block group was non\u2010inferior to those allocated to the conventional group (mean difference\u2009\u2212\u20090.99, 95%CI \u201011.97\u20139.98, p\u2009=\u20090.011). Patients allocated to the continuous erector spinae plane block group showed superior quality of recovery\u201015 scores at 24\u2009h (median difference 11, 95%CI 6\u201316, p\u2009&lt;\u20090.001) and 48\u2009h postoperatively (median difference 10, 95%CI 7\u201315, p\u2009&lt;\u20090.001), alongside reduced postoperative pulmonary complications (relative risk 0.45, 95%CI 0.21\u20130.96, p\u2009=\u20090.031). Safety outcomes favoured continuous erector spinae plane block, with lower incidences of postoperative nausea (relative risk 0.17, 95%CI 0.04\u20130.73, p\u2009=\u20090.005); retching (relative risk 0.11, 95%CI 0.02\u20130.89, p\u2009=\u20090.023); and dizziness (relative risk 0.22, 95%CI 0.07\u20130.72, p\u2009=\u20090.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Following video\u2010assisted thoracoscopic lung resection, continuous erector spinae plane block provides non\u2010inferior postoperative analgesia compared with conventional opioid\u2010based regimen whilst enhancing recovery quality significantly and reducing complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16651","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:15:44Z","timestamp":1750648544000},"page":"1226-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analgesic efficacy of continuous erector spinae plane block vs. opioid\u2010based regimen for postoperative pain management following video\u2010assisted thoracoscopic lung resection: a prospective, randomised, open\u2010label, non\u2010inferiority trial"],"prefix":"10.1111","volume":"80","author":[{"given":"Junqiang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Department of Anaesthesiology First Affiliated Hospital of Guangzhou Medical University of Chinese Medicine  Guangzhou Guangdong China"},{"name":"Guangdong Clinical Research Academy of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Second People's Hospital of Jiangmen  Jiangmen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0436-3602","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Guangzhou Institute of Cancer Research, Affiliated Cancer Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.05.028"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)00173\u2010X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201024\u2010825"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003399"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy301"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15609"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375\u20109393.23.17510\u20109"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005730"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2024.7.E803"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244\u2010021\u201001151\u2010x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013763.pub3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2020.110063"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2024.111448"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.06.020"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.01.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.11.021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa270"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000001174"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S480333"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102018\u2010000031"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001788"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.05.041"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010023\u201001136\u2010z"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102019\u2010100827"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.07.051"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102023\u2010105047"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110770"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.04.044"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.08.041"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:09:57Z","timestamp":1757923797000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/anae.16651"],"URL":"https:\/\/doi.org\/10.1111\/anae.16651","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}