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Ensuring a safe and effective approach to the selection, insertion and care of vascular access devices should be a priority for all practitioners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This updated consensus statement builds upon previous iterations of safe vascular access guidelines. An expert, multidisciplinary, multi\u2010society working party agreed on major themes and conducted a review of literature and best practice to build a comprehensive body of work. This was followed by a two\u2010round Delphi process to agree on specific recommendations and to inform these concise guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We agreed successfully 15 recommendations encompassing operational, training and clinical issues with an emphasis on a holistic approach to vascular access and long\u2010term vessel health. These recommendations were divided into six major themes, covering: process (vascular access teams and responsiveness key performance indicators); device selection; insertion, including the use of safety standards, ultrasound, catheter tip position and vein\/catheter ratios; the management of anticoagulation therapy, catheter\u2010related thrombosis and coagulopathies; specific patient groups, including patients requiring renal replacement therapy, following mastectomy and axillary lymph node resection and the use of peripheral vasoconstrictors; and training in advanced vascular access.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>It is hoped that these guidelines, together with the larger body of work, will improve the care of patients who require vascular access, embed a more holistic approach to vascular access and lifetime vein preservation, and support staff and hospitals with vascular access service 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