{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:38:57Z","timestamp":1793039937531,"version":"4.5.0"},"reference-count":108,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta\u2010analysis of randomised controlled trials assessing the effect of pharmacological interventions on the incidence of postoperative delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases were searched from inception to September 2024. Our search was updated in January 2025. Eligible studies included randomised controlled trials reporting the incidence of postoperative delirium in patients having cardiac surgery treated with pharmacological interventions. Bayesian models were used to estimate risk ratios (RR) and mean differences with 95%CrI through Markov chain Monte Carlo. Interventions were ranked using the surface under the cumulative ranking curve. Sensitivity analyses and grading of recommendations, assessment, development and evaluation assessment were conducted to evaluate the robustness and certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010nine randomised controlled trials comprising 24,827 patients were included, with 29 pharmacological interventions compared. Dexmedetomidine combined with melatonin was the most effective intervention, reducing the incidence of postoperative delirium compared with placebo (risk ratio 0.31, 95%CrI 0.13\u20130.69; low certainty). Dexmedetomidine with melatonin also significantly decreased intensive care unit stay (2.4\u2009days, 95%CrI \u20103.50\u20131.10) and hospital stay (1.32\u2009days, 95%CrI \u20102.09 to \u20100.57). Other interventions, including ketamine and risperidone, showed potential efficacy but with low or very low certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We identified dexmedetomidine with melatonin as the most effective pharmacological strategy for preventing postoperative delirium following cardiac surgery. Whilst these findings highlight potential benefits, the low certainty of evidence underscores the need for more high\u2010quality primary evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.16757","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:09:36Z","timestamp":1756714176000},"page":"274-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of peri\u2010operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6544-8450","authenticated-orcid":false,"given":"Ivo","family":"Queiroz","sequence":"first","affiliation":[{"name":"Department of Medicine APAMI Hospital  Vit\u00f3ria de Santo Ant\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Gallo Ruelas","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences Instituto de Investigaci\u00f3n Nutricional  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Medicine Nove de Julho University  S\u00e3o Bernardo do Campo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L. R.","family":"Defante","sequence":"additional","affiliation":[{"name":"Department of Medicine Redentor University Center  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Florencio de Mesquita","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulio","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ximenes Mendes","sequence":"additional","affiliation":[{"name":"Department of Medicine Unichristus  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuri","family":"Ferreira Felix","sequence":"additional","affiliation":[{"name":"Department of Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Medicine Nove de Julho University  S\u00e3o Bernardo do Campo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Oliva Morgado Ferreira","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Mato Grosso  Sinop Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno B.","family":"Righetto","sequence":"additional","affiliation":[{"name":"Department of Medicine University Positivo  Valinhos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Smischney","sequence":"additional","affiliation":[{"name":"Department of Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale School of Medicine  New Haven CT USA"},{"name":"Department of Statistics Yale School of Public Health  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhejiang University School of Medicine Children's Hospital  Hangzhou China"},{"name":"Department of Anaesthetics Imperial College London Chelsea and Westminster Hospital  London UK"},{"name":"Department of Anesthesiology The First Affiliated Hospital of Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1112923"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000032991"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0000000000001876"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000005172"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010023\u201002378\u20105"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2019.1688450"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.joacp_521_23"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010023\u201002367\u20108"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)31467\u20108"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2022067"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ed000142"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02763869.2019.1588072"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm\u20102022\u2010111928"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental\u20102019\u2010300117"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2019013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029600500402"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1329"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010024625"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3900"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010074495"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev303"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000002179"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.11.037"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjar.2024.241622"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_303_17"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu367"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.07.006"},{"key":"e_1_2_6_34_1","first-page":"3252","article-title":"Comparative study evaluating effects of intravenous sedation by dexmedetomidine and propofol on patient hemodynamics and postoperative outcomes in cardiac surgery","volume":"15","author":"Chhabra V","year":"2024","journal-title":"J Cardiovasc Dis Res"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.09.024"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000162565.18193.e5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15802"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14144"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000000951"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002175\u20102"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12618"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010200110000\u201000011"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13741\u2010024\u201000371\u20101"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16162"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e31819da780"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1532\/hsf.4073"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560\u2010024\u201000750\u20102"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102024\u2010002743"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000001873"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.s439703"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.12.021"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010024\u201004842\u20101"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13927"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.30476\/ijms.2020.82860.1146"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm\u2010138317"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000006257"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.03.182"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.11.028"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090210\u2010w"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2309"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.11.038"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170757"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.02.035"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.10.026"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/11101849.2021.1885956"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.50.3.206"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.22122\/arya.v17i0.2371"},{"key":"e_1_2_6_68_1","first-page":"137","article-title":"Prophylaxis of dexamethasone protects patients from further post\u2010operative delirium after cardiac surgery: a randomized trial","volume":"18","author":"Mardani D","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.22122\/arya.v15i1.1748"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.10.041"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4939"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2014.47.3.249"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer083"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057x0703500509"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202308_33418"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658\u2010354x.154715"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101796"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.05.009"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010008\u20101157\u2010x"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010021\u201001969\u20105"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102044.2011.06704.x"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000001433"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.217562"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000000248"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e3181b6a783"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_46_18"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1532\/hsf.4049"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2019.09.016"},{"key":"e_1_2_6_89_1","first-page":"1066","article-title":"Study on cerebral protective effect of dexmedetomidine during anesthesia in cardiac valve replacement surgery","volume":"10","author":"Shu A","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.aca_85_20"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.12.036"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet072"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.6855"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.12.035"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0234"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12552.2"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30631\u20100"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2024.05.027"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15983"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(15)00273\u20101"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.aca_106_22"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000006925"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-018-0282-5"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.843069"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010023\u201001689\u20106"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137006"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S320745"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.965661"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010024\u201002715\u20102"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.16757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.16757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:39:53Z","timestamp":1769719193000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.16757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/anae.16757"],"URL":"https:\/\/doi.org\/10.1111\/anae.16757","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}