{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:47:52Z","timestamp":1774673272129,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peri\u2010operative respiratory adverse events remain a major cause of morbidity and mortality in children undergoing general anaesthesia; those with asthma are at higher risk. The aim of this feasibility study was to determine whether pre\u2010operative measurements of fractional exhaled nitric oxide and the forced oscillation technique are feasible in children, and to explore whether these measurements can predict peri\u2010operative respiratory adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assigned children into respiratory or control groups, according to the presence or absence of respiratory symptoms. We recorded pre\u2010operative measurements of fractional exhaled nitric oxide as well as respiratory mechanics, as determined by the forced oscillation technique. We then recorded the incidence of peri\u2010operative respiratory adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 120 children of which 116 were included. Fractional exhaled nitric oxide and respiratory mechanics (forced oscillation technique) were recorded in 106\/116 (91%) and 71\/116 (61%), respectively. Peri\u2010operative respiratory adverse events occurred in 17\/116 (15%) patients but there was no difference between groups (OR 2.11, 95%CI 0.74\u20136.55). Pre\u2010operative fractional exhaled nitric oxide levels did not predict the occurrence of peri\u2010operative respiratory adverse events. The measurement of respiratory mechanics using the forced oscillation technique did not predict peri\u2010operative respiratory adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We have shown the feasibility of study enrolment and pre\u2010operative fractional exhaled nitric oxide measurement but had difficulty obtaining measurements of respiratory mechanics (forced oscillation technique). Neither test improved the prediction of peri\u2010operative respiratory adverse events reliably in this group of patients. A thorough pre\u2010operative clinical history combined with care by an experienced paediatric anaesthetist remains the most reliable means of reducing peri\u2010operative respiratory adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.70056","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:15:59Z","timestamp":1762766159000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of the pre\u2010operative measurement of fractional exhaled nitric oxide and respiratory mechanics to predict respiratory outcomes in children undergoing general anaesthesia"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-0690","authenticated-orcid":false,"given":"Neil","family":"Hauser","sequence":"first","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of Anaesthesia and Pain Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"Division of Emergency Medicine, Anaesthesia and Pain Medicine The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sommerfield","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of Anaesthesia and Pain Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"Division of Emergency Medicine, Anaesthesia and Pain Medicine The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of Anaesthesia and Pain Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"Division of Emergency Medicine, Anaesthesia and Pain Medicine The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aine","family":"Sommerfield","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of Anaesthesia and Pain Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"Division of Emergency Medicine, Anaesthesia and Pain Medicine The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Evans","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of Anaesthesia and Pain Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"School of Physics, Mathematics and Computing The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Nazim","family":"Khan","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Institute for Paediatric Perioperative Excellence The University of Western Australia  Perth WA Australia"},{"name":"Department of Mathematics and Statistics The University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"O'Dea","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Perth Children's Hospital  Perth WA Australia"},{"name":"Wal\u2010Yan Respiratory Research Centre Telethon Kids Institute  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta S","family":"von Ungern\u2010Sternberg","sequence":"additional","affiliation":[{"name":"Perioperative Medicine Team, Perioperative Care Program Telethon Kids Institute  Perth WA Australia"},{"name":"Department of 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