{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T05:27:53Z","timestamp":1786771673145,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aortic stenosis is a risk factor for adverse outcomes following non\u2010cardiac surgery; however, existing data regarding peri\u2010operative morbidity and mortality in this patient cohort remain conflicted. This systematic review and meta\u2010analysis aimed to quantify the peri\u2010operative risks in patients with aortic stenosis undergoing non\u2010cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following the development of our search strategy, we searched databases for relevant studies. The primary endpoint was all\u2010cause in\u2010hospital or 30\u2010day mortality associated with aortic stenosis in patients undergoing non\u2010cardiac surgery. Secondary endpoints included: myocardial infarction; heart failure; stroke; delirium; venous thromboembolism; and acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen studies involving 100,486 patients were included. The estimated all\u2010cause mortality was 3.8% (95%CI 3.7\u20133.9%) for patients with any degree of aortic stenosis and 9.6% (95%CI 7.7\u201312.1%) for those with severe aortic stenosis. A meta\u2010analysis of 14 comparative studies involving 2,885,254 patients revealed significantly increased mortality in patients with aortic stenosis compared with those without aortic stenosis (relative risk 1.58, 95%CI 1.18\u20132.12, p\u2009&lt;\u20090.001). Aortic stenosis was also associated with an elevated risk of postoperative myocardial infarction (relative risk 1.79, 95%CI 1.2\u20132.67, p\u2009&lt;\u20090.001) and heart failure (relative risk 2.06, 95%CI 1.19\u20133.59, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Aortic stenosis in patients undergoing non\u2010cardiac surgery is associated with a three\u2010fold relative increase in the risk of mortality. These results highlight the need for further delineation of which surgical procedures are associated with the greatest risk of poor peri\u2010operative outcomes to guide heightened surveillance protocols, optimised peri\u2010operative management and thresholds for pre\u2010operative intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.70084","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:32:02Z","timestamp":1765603922000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peri\u2010operative risk of non\u2010cardiac surgery in patients with aortic stenosis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7725-983X","authenticated-orcid":false,"given":"Amelia","family":"Place","sequence":"first","affiliation":[{"name":"Department of Cardiology The Royal Melbourne Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2302-5588","authenticated-orcid":false,"given":"Thalys Sampaio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Medicine Melbourne Medical School, The University of Melbourne  Melbourne VIC Australia"},{"name":"Department of Cardiology Austin Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-4862","authenticated-orcid":false,"given":"Phillip S.","family":"Naimo","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Royal Melbourne Hospital  Melbourne VIC Australia"},{"name":"Department of Medicine Melbourne Medical School, The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-4891","authenticated-orcid":false,"given":"Melissa G. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Royal Melbourne Hospital  Melbourne VIC Australia"},{"name":"Department of Medicine Melbourne Medical School, The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-3185","authenticated-orcid":false,"given":"Riley J.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Royal Melbourne Hospital  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-7680","authenticated-orcid":false,"given":"Laurence","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Austin Health  Melbourne VIC Australia"},{"name":"Department of Anaesthesia Austin Health  Melbourne VIC 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