{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:07:29Z","timestamp":1783847249685,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1066482"],"award-info":[{"award-number":["2022R1F1A1066482"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Previous studies comparing the effects of general and regional anaesthesia on postoperative opioid use have focused primarily on the immediate postoperative period, with limited investigations into long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 558,944 patients aged \u2265\u200918\u2009y who underwent one of nine surgical procedures (thoracotomy; total hip arthroplasty; total knee arthroplasty; shoulder arthroplasty; transurethral resection of the prostate; inguinal hernia repair; knee arthroscopy; varicose vein surgery; and caesarean section) that required regional anaesthesia, general anaesthesia or combined general\/regional anaesthesia. The primary outcome was the incidence of persistent postoperative opioid utilisation, which was defined as having filled \u2265\u200910 prescriptions or a supply of &gt;\u2009120\u2009days between postoperative days 91 and 365. Age, sex, medical comorbidities, pre\u2010operative medications and surgery type were balanced among regional anaesthesia, general anaesthesia and combined general\/regional anaesthesia using pairwise propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>General anaesthesia had significantly higher odds than regional anaesthesia for the development of persistent postoperative opioid utilisation (odds ratio 2.13, 95%CI 1.50\u20133.01, p\u2009&lt;\u20090.001). The odds ratio of general anaesthesia vs. combined general\/regional anaesthesia was significant in patients undergoing thoracotomy (odds ratio 1.47, 95%CI 1.25\u20131.74, p\u2009&lt;\u20090.001). In the overall population, the regional anaesthesia group consumed fewer opioids than the other groups. Among the patients undergoing thoracotomy, the combined general\/regional anaesthesia group consumed fewer opioids than the general anaesthesia group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study found that regional anaesthesia was associated with a reduction in persistent postoperative opioid utilisation, particularly in patients undergoing thoracotomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.70184","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:21:13Z","timestamp":1773904873000},"page":"1068-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of anaesthesia type on development of persistent postoperative opioid utilisation: a South Korean nationwide cohort study"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-0054","authenticated-orcid":false,"given":"Jonghae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Daegu Catholic University School of Medicine Daegu Catholic University Medical Center  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyu","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Daegu Catholic University School of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-4191","authenticated-orcid":false,"given":"Eugene","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Hanyang University Hanyang University Medical Center  Seoul South 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