{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:56Z","timestamp":1791888296104,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Standardised Endpoints in Perioperative Medicine Initiative recommends the 12\u2010item WHO Disability Assessment Schedule (WHODAS) 2.0 to measure postoperative functional impairment. However, evidence describing long\u2010term postoperative disability, particularly at 1\u2009year, remains limited. This study aimed to: describe disability up to 1\u2009year after non\u2010cardiac, non\u2010neurosurgical procedures; examine associations between periprocedural risk, postoperative complications and new\u2010onset disability; and evaluate associations between social support, delirium, and frailty and postoperative disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, multicentre cohort study. The primary endpoint was new onset clinically significant disability (an increase in WHODAS 2.0 score\u2009\u2265\u20095% points from baseline to a final score\u2009\u2265\u200935%) or death at 1\u2009year. Independent variables included: periprocedural risk; postoperative complications; frailty; and patient\u2010reported social support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1081 patients were included: 726 (67%) male, median (IQR) [range] age 67 (60\u201375 [50\u2013101]) y. New onset clinically significant disability was present in 139\/1081 (12.9%) patients at 1\u2009year and in 238\/1066 (22.3%) patients at 30\u2009days. Periprocedural risk (adjusted odds ratio (aOR) 1.05, 95%CI 1.03\u20131.07, per percent in American College of Surgeons National Surgical Quality Improvement Program score) and postoperative complications of all grades were associated with 1\u2010year new onset clinically significant disability. New onset (1\u2009year) clinically significant disability was not associated with social support: OR 0.87, 95%CI 0.54\u20131.39 for moderate; and OR 0.76, 95%CI 0.47\u20131.24 for strong social support. Frailty was strongly associated with new onset clinically significant disability after 1 year (aOR 3.97, 95%CI 2.54\u20136.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>One year after non\u2010cardiac surgery, 13% of surviving patients experienced a\u00a0new onset clinically significant disability. Postoperative complications, even those of low severity, were associated with new onset postoperative disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.70248","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:06:23Z","timestamp":1781175983000},"page":"1497-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Disability after non\u2010cardiac surgery \u2013 patient\u2010centred outcomes and resource utilisation after non\u2010cardiac surgery (\n                    <scp>PACORUS<\/scp>\n                    ): a prospective multicentre cohort study*"],"prefix":"10.1111","volume":"81","author":[{"given":"Alexandra","family":"Stroda","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Larmann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty RWTH Aachen University  Aachen Germany"},{"name":"Department of Anaesthesiology, Medical Faculty University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Icks","sequence":"additional","affiliation":[{"name":"Centre for Health and Society, Institute for Health Services Research and Health Economics Heinrich\u2010Heine\u2010University  Duesseldorf Germany"},{"name":"German Diabetes Center, Leibniz Center for Diabetes Research Institute for Health Services Research and Health Economics  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Moritz","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Medicine RKH Hospital Ludwigsburg  Ludwigsburg Germany"},{"name":"Department of Anaesthesiology and Intensive Care Medicine University Hospital Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mathes","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine University of Cologne, Faculty of Medicine and University Hospital Cologne  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Werdehausen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Medical Faculty University of Magdeburg  Magdeburg Germany"},{"name":"Department of Anaesthesiology and Intensive Care Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Thaler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ziemann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"M'Pembele","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Tenge","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Bu\u00dfhoff","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Rallis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Medical Faculty University of Duesseldorf  Duesseldorf 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