{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:28:18Z","timestamp":1794025698881,"version":"4.8.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["associationofanaesthetists-publications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The incidence of hip fractures is rising with the ageing population. For patients living with severe frailty and limited life expectancy, non\u2010operative management is increasingly considered after shared decision\u2010making. Given the limited availability of long\u2010term analgesic options, alternative techniques are needed. Chemical neurolysis via the pericapsular nerve group block approach can selectively target sensory innervation of the hip.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective multicentre cohort study was conducted at seven Dutch hospitals. Patients who chose non\u2010operative management for a hip fracture and met the indication for neurolysis were enrolled. Patient\u2010reported outcomes were assessed at 24\u2009h, 1\u2009week, 30\u2009days and 3\u2009months and included: quality of life; pain; analgesic use; mobility; complications; and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 103 patients (mean (SD) age 87 (6.4) y); 51% were nursing home residents and 76% had cognitive impairment. The pericapsular nerve group block was performed under ultrasound guidance, with second needle placement in 14\/103 (14%) patients. Mean (SD) injected volume of phenol 6% was 10 (3.1) ml. At 1\u2009week, 34\/36 (94%) patients reported acceptable pain at rest and 47\/53 (89%) reported no or acceptable pain when washing and dressing. A bed\u2010chair transfer was possible in 24\/53 (45%) patients at 1\u2009week. No procedure\u2010related adverse events were reported. Mortality rate was 72\/91 (79%) after 3\u2009months, with a 30\u2010day mortality of 56\/91 (62%) and median (IQR [range]) survival of 9 (6\u201324 [0\u201385]) days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The pericapsular nerve group block with phenol 6% is an effective, minimally invasive procedure for pain management in addition to opioid\u2010based pain relief in patients living with frailty, when surgery is not chosen. Procedure standardisation may improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anae.70346","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:25:11Z","timestamp":1788931511000},"page":"1673-1685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pericapsular nerve group block with phenol for non\u2010operative hip fracture management in patients living with frailty: a prospective multicentre cohort study"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-3087","authenticated-orcid":false,"given":"Rachel J. H.","family":"Smits","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Pain and Palliative Medicine Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5259-6381","authenticated-orcid":false,"given":"Marte I.","family":"Lommerse","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery Amsterdam University Medical Centre  Amsterdam the Netherlands"},{"name":"Department of Internal Medicine, Geriatrics Section Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-5866","authenticated-orcid":false,"given":"Hugo H.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart G.","family":"Wasmoeth","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology St. Antonius Hospitals  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-9205","authenticated-orcid":false,"given":"Glenn","family":"van de Vossenberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Zuyderland Hospital  Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1258-1977","authenticated-orcid":false,"given":"Gezina T. M. L.","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Dijklander Hospital  Hoorn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-6828","authenticated-orcid":false,"given":"Henk J.","family":"Schuijt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geriatrics Section Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-6356","authenticated-orcid":false,"given":"Kris C. P.","family":"Vissers","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain and Palliative Medicine Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna C.","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geriatrics Section Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-1796","authenticated-orcid":false,"given":"Jan Willem","family":"Kallewaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Rijnstate Hospital  Arnhem the Netherlands"},{"name":"Department of Anaesthesiology and Pain Medicine Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-9314","authenticated-orcid":false,"given":"Selina E. I.","family":"van der Wal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain and Palliative Medicine Radboudumc  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch\u2010PENG registry collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2025.112322"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4821"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu065"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.0089"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.08.027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068\u2010022\u201002012\u2010y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164589"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010083429"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zefq.2023.06.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbaf155"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.108B8.BJJ\u20102025\u20101465.R1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2008\/11\/s105"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001159.pub3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000337.pub2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000847"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000701"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102024\u2010105427"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004172"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010019\u201001448\u2010y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2025.111872"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010095738"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.02.022"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010011\u20109903\u2010x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2003.10.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0885\u20103924(01)00333\u20105"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102021\u2010103023"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499020936848"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000002778"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001600"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001800"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375\u20109393.24.18534\u20103"},{"key":"e_1_2_6_34_1","unstructured":"Dutch Society of Anaesthesiology.[Neuraxis block and anticoagulation].2026.https:\/\/richtlijnendatabase.nl\/richtlijn\/neuraxisblokkade_en_antistolling\/startpagina_\u2010_neuraxisblokkade_en_antistolling.html. (accessed 20\/05\/2026)."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102023\u2010104419"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120700021998959"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16732"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/11207000251408435"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2021.1959155"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.04.045"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16735"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.70153"}],"container-title":["Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.70346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anae.70346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anae.70346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:21:40Z","timestamp":1794025300000},"score":1,"resource":{"primary":{"URL":"https:\/\/associationofanaesthetists-publications.onlinelibrary.wiley.com\/doi\/10.1111\/anae.70346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1111\/anae.70346"],"URL":"https:\/\/doi.org\/10.1111\/anae.70346","archive":["Portico"],"relation":{},"ISSN":["0003-2409","1365-2044"],"issn-type":[{"value":"0003-2409","type":"print"},{"value":"1365-2044","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}