{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:02Z","timestamp":1787013842638,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":940,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1111\/and.12069","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T08:34:34Z","timestamp":1359966874000},"page":"246-253","source":"Crossref","is-referenced-by-count":37,"title":["Antioxidant effect of manganese on the testis structure and sperm parameters of formalin-treated mice"],"prefix":"10.1155","volume":"46","author":[{"given":"S.","family":"Tajaddini","sequence":"first","affiliation":[{"name":"Department of Basic Sciences; Payame Noor University; Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences; Payame Noor University; Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Behnam","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Tehran University of Medical Sciences; Tehran Iran"},{"name":"Department of Medical Genetics and Molecular Biology; School of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bakhtiyari","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Tehran University of Medical Sciences; Tehran Iran"},{"name":"Department of Anatomical Science; School of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Joghataei","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Tehran University of Medical Sciences; Tehran Iran"},{"name":"Department of Anatomical Science; School of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Science; School of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Amini","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Amanpour","sequence":"additional","affiliation":[{"name":"Vali-Asr Reproductive Health Research Center; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Koruji","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Tehran University of Medical Sciences; Tehran Iran"},{"name":"Department of Anatomical Science; School of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,3]]},"reference":[{"key":"10.1111\/and.12069-BIB0001|and12069-cit-0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1071\/RD9940019","article-title":"A free radical theory of male infertility","volume":"6","author":"Aitken","year":"1994","journal-title":"Reprod Fertil Dev"},{"key":"10.1111\/and.12069-BIB0002|and12069-cit-0002","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1530\/rep.0.1220497","article-title":"Oxidative stress, DNA damage and the Y chromosome","volume":"122","author":"Aitken","year":"2001","journal-title":"Reproduction"},{"key":"10.1111\/and.12069-BIB0003|and12069-cit-0003","first-page":"250","volume-title":"Male Fertility and Lipid Metabolism, AOCS Press, Champaign, USA","author":"Arabi","year":"2003"},{"key":"10.1111\/and.12069-BIB0004|and12069-cit-0004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1590\/S0036-46652010000100007","article-title":"Modulatory activity of antioxidants against the toxicity of Rifampicin in vivo","volume":"52","author":"Awodele","year":"2010","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"10.1111\/and.12069-BIB0005|and12069-cit-0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1385\/BTER:112:3:193","article-title":"Impact of Cu and Fe concentrations on oxidative damage in male infertility","volume":"112","author":"Aydemir","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"10.1111\/and.12069-BIB0006|and12069-cit-0006","first-page":"90","article-title":"Effect of manganese on bovine sperm motility, viability, and lipid peroxidation in vitro","volume":"5","author":"Bansal","year":"2008","journal-title":"Anim Reprod"},{"key":"10.1111\/and.12069-BIB0007|and12069-cit-0007","first-page":"149","article-title":"Mn2+: a potent antioxidant and stimulator of sperm capacitation and acrosome reaction in crossbred cattle bulls","volume":"51","author":"Bilaspuri","year":"2008","journal-title":"Arch Tierz"},{"key":"10.1111\/and.12069-BIB0008|and12069-cit-0008","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0093-691X(01)00702-6","article-title":"Reactive oxygen species-mediated loss of bovine sperm motility in egg yolk Tris extender: protection by pyruvate, metal chelators and bovine liver or oviductal fluid catalase","volume":"57","author":"Bilodeau","year":"2002","journal-title":"Theriogenology"},{"key":"10.1111\/and.12069-BIB0009|and12069-cit-0009","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4161\/oxim.2.3.8804","article-title":"Manganese provides antioxidant protection for sperm cryopreservation that may offer new consideration for clinical fertility","volume":"2","author":"Cheema","year":"2009","journal-title":"Oxid Med Cell Longev"},{"key":"10.1111\/and.12069-BIB0010|and12069-cit-0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/BTER:110:2:163","article-title":"Effects of acute manganese chloride exposure on lipid peroxidation and alteration of trace metals in rat brain","volume":"110","author":"Chen","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"10.1111\/and.12069-BIB0011|and12069-cit-0011","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/tx025614r","article-title":"Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links","volume":"16","author":"Cheng","year":"2003","journal-title":"Chem Res Toxicol"},{"key":"10.1111\/and.12069-BIB0012|and12069-cit-0012","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/oem.2004.014324","article-title":"Formaldehyde exposure and leukaemia","volume":"61","author":"Collins","year":"2004","journal-title":"Occup Environ Med"},{"key":"10.1111\/and.12069-BIB0013|and12069-cit-0013","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/bdrc.20141","article-title":"Spermatogonial stem cells: mouse and human comparisons","volume":"87","author":"Dym","year":"2009","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1111\/and.12069-BIB0014|and12069-cit-0014","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-4274(00)00312-X","article-title":"Effects of long-term exposure to manganese chloride on fertility of male and female mice","volume":"119","author":"Elbetieha","year":"2011","journal-title":"Toxicol Lett"},{"key":"10.1111\/and.12069-BIB0015|and12069-cit-0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2478\/v10102-010-0013-3","article-title":"Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice","volume":"3","author":"Eybl","year":"2010","journal-title":"Interdiscip Toxicol"},{"key":"10.1111\/and.12069-BIB0016|and12069-cit-0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(08)60099-9","article-title":"Reactions of nucleic acids and nucleoproteins with formaldehyde","volume":"13","author":"Feldman","year":"1973","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"10.1111\/and.12069-BIB0017|and12069-cit-0017","first-page":"231","article-title":"Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues","volume":"5","author":"Fujii","year":"2003","journal-title":"Asian J Androl"},{"key":"10.1111\/and.12069-BIB0018|and12069-cit-0018","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.anireprosci.2009.11.001","article-title":"Thawing boar semen in the presence of seminal plasma: effects on sperm quality and fertility","volume":"119","author":"Garcia","year":"2010","journal-title":"Anim Reprod Sci"},{"key":"10.1111\/and.12069-BIB0019|and12069-cit-0019","first-page":"167","article-title":"Formaldehyde exposure induces histopathological and morphometric changes in the rat testis","volume":"66","author":"Golalipour","year":"2007","journal-title":"Folia Morphol"},{"key":"10.1111\/and.12069-BIB0020|and12069-cit-0020","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.5713\/ajas.2010.90519","article-title":"The effect of xylene and formaldehyde inhalation on testicular tissue in rats","volume":"23","author":"Gules","year":"2010","journal-title":"Asian-Aust J Anim Sci"},{"key":"10.1111\/and.12069-BIB0021|and12069-cit-0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(00)99001-6","article-title":"Cellular and molecular biology of capacitation and acrosome reaction in spermatozoa","volume":"199","author":"Guraya","year":"2000","journal-title":"Int Rev Cytol"},{"key":"10.1111\/and.12069-BIB0022|and12069-cit-0022","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchemneu.2005.01.001","article-title":"Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies","volume":"29","author":"Gurel","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"10.1111\/and.12069-BIB0023|and12069-cit-0023","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9440(10)63803-5","article-title":"Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies","volume":"162","author":"Jauniaux","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1111\/and.12069-BIB0024|and12069-cit-0024","first-page":"45","article-title":"Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat","volume":"68","author":"Khaki","year":"2008","journal-title":"Folia Morphol"},{"key":"10.1111\/and.12069-BIB0025|and12069-cit-0025","first-page":"57","article-title":"Protective effects of quercetin on spermatogenesis in streptozotocin-induced diabetic rat","volume":"8","author":"Khaki","year":"2009","journal-title":"J Med Plant"},{"key":"10.1111\/and.12069-BIB0026|and12069-cit-0026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1642-431X(12)60074-6","article-title":"The generation of spermatogonial stem cells and spermatogonia in mammals","volume":"12","author":"Kolasa","year":"2012","journal-title":"Reprod Biol"},{"issue":"Suppl 1","key":"10.1111\/and.12069-BIB0027|and12069-cit-0027","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humrep\/10.suppl_1.15","article-title":"Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects","volume":"10","author":"Lamirande","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12069-BIB0028|and12069-cit-0028","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3168\/jds.S0022-0302(96)76592-X","article-title":"Modulation of postthaw motility, survival, calcium uptake, and fertility of bovine sperm by magnesium and manganese","volume":"79","author":"Lapointe","year":"1996","journal-title":"J Dairy Sci"},{"key":"10.1111\/and.12069-BIB0029|and12069-cit-0029","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/cm.970100309","article-title":"Calcium regulation of flagellar curvature and swimming pattern in triton X-100-extracted rat sperm","volume":"10","author":"Lindemann","year":"1988","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1111\/and.12069-BIB0030|and12069-cit-0030","first-page":"80","article-title":"Inhibitory effects of formaldehyde on the reproductive system of male rats","volume":"39","author":"Majumder","year":"1995","journal-title":"Indian J Physiol Pharmacol"},{"key":"10.1111\/and.12069-BIB0031|and12069-cit-0031","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-005-0009-z","article-title":"Spermatogonial stem cell transplantation and testicular function","volume":"322","author":"McLean","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1111\/and.12069-BIB0032|and12069-cit-0032","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.3168\/jds.S0022-0302(93)77620-1","article-title":"Oxidative stress, antioxidants, and animal function","volume":"76","author":"Miller","year":"1993","journal-title":"J Dairy Sci"},{"key":"10.1111\/and.12069-BIB0033|and12069-cit-0033","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1086\/301895","article-title":"Male infertility and the genetics of spermatogenesis","volume":"62","author":"Okabe","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1111\/and.12069-BIB0034|and12069-cit-0034","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0946-672X(02)80038-4","article-title":"Testicular zinc, copper and iron concentrations in male rats exposed to subacute and subchronic formaldehyde gas inhalation","volume":"16","author":"Ozen","year":"2002","journal-title":"J Trace Elem Med Biol"},{"key":"10.1111\/and.12069-BIB0035|and12069-cit-0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1191\/0748233705th235oa","article-title":"Effect of formaldehyde inhalation on Hsp70 in seminiferous tubules of rat testes: an immunohistochemical study","volume":"21","author":"Ozen","year":"2005","journal-title":"Toxicol Ind Health"},{"key":"10.1111\/and.12069-BIB0036|and12069-cit-0036","first-page":"1","volume-title":"Histological and Histopathological Evaluation of the Testis","author":"Russell","year":"1990"},{"key":"10.1111\/and.12069-BIB0037|and12069-cit-0037","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tox.2005.02.006","article-title":"Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species","volume":"210","author":"Saito","year":"2005","journal-title":"Toxicology"},{"key":"10.1111\/and.12069-BIB0038|and12069-cit-0038","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.2741\/A146","article-title":"Oxidative stress and role of antioxidants in normal and abnormal sperm function","volume":"1","author":"Sikka","year":"1996","journal-title":"Front Biosci"},{"key":"10.1111\/and.12069-BIB0040|and12069-cit-0040","first-page":"544","article-title":"Effects of formaldehyde on germ cells of male mice","volume":"32","author":"Tang","year":"2003","journal-title":"Wei Sheng Yan Jiu"},{"key":"10.1111\/and.12069-BIB0041|and12069-cit-0041","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/humupd\/6.6.532","article-title":"Consequences on offspring of abnormal function in ageing gametes","volume":"6","author":"Tarin","year":"2000","journal-title":"Hum Reprod Update"},{"key":"10.1111\/and.12069-BIB0042|and12069-cit-0042","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1095\/biolreprod59.4.753","article-title":"Antioxidant systems in rat epididymal spermatozoa","volume":"59","author":"Tramer","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12069-BIB0043|and12069-cit-0043","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cryobiol.2010.05.005","article-title":"The effect of raffinose and methionine on frozen\/thawed Angora buck (Capra hircus ancryrensis) semen quality, lipid peroxidation and antioxidant enzyme activities","volume":"61","author":"Tuncer","year":"2010","journal-title":"Cryobiology"},{"key":"10.1111\/and.12069-BIB0044|and12069-cit-0044","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0015-0282(01)01850-7","article-title":"Effect of endotoxin-induced reactive oxygen species on sperm motility","volume":"76","author":"Urata","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12069-BIB0045|and12069-cit-0045","doi-asserted-by":"crossref","first-page":"20693","DOI":"10.1074\/jbc.M002323200","article-title":"Sperm motility is dependent on a unique isoform of the Na, K-ATPase","volume":"275","author":"Woo","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/and.12069-BIB0046|and12069-cit-0046","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrgentox.2005.08.005","article-title":"Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and low-level short-term exposed waiters","volume":"588","author":"Ye","year":"2005","journal-title":"Mutat Res"},{"key":"10.1111\/and.12069-BIB0047|and12069-cit-0047","first-page":"326","article-title":"Effect of tail-suspension on the reproduction of adult male rats","volume":"12","author":"Zhou","year":"2006a","journal-title":"Zhonghua Nan Ke Xue"},{"key":"10.1111\/and.12069-BIB0048|and12069-cit-0048","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1745-7262.2006.00198.x","article-title":"The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats","volume":"8","author":"Zhou","year":"2006b","journal-title":"Asian J Androl"},{"key":"10.1111\/and.12069-BIB0049|and12069-cit-0049","first-page":"566","article-title":"Reproductive toxicity of formaldehyde to adult male rats and the functional mechanism concerned","volume":"37","author":"Zhou","year":"2006c","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1111\/and.12069-BIB0050|and12069-cit-0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/0748233710393401","article-title":"Assessment of the potential reproductive toxicity of long-term exposure of adult male rats to low-dose formaldehyde","volume":"27","author":"Zhou","year":"2011","journal-title":"Toxicol Ind Health"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12069\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:34:55Z","timestamp":1671521695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12069","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2,3]]}}}