{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:56Z","timestamp":1791351416754,"version":"4.3.1"},"reference-count":42,"publisher":"Hindawi Limited","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":725,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1111\/and.12156","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T08:25:27Z","timestamp":1378455927000},"page":"831-836","source":"Crossref","is-referenced-by-count":24,"title":["Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report"],"prefix":"10.1155","volume":"46","author":[{"given":"M.","family":"Vozdova","sequence":"first","affiliation":[{"name":"Department of Genetics and Reproduction; Veterinary Research Institute; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rybar","sequence":"additional","affiliation":[{"name":"Department of Genetics and Reproduction; Veterinary Research Institute; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kloudova","sequence":"additional","affiliation":[{"name":"Sanatorium HELIOS; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Prinosilova","sequence":"additional","affiliation":[{"name":"Department of Genetics and Reproduction; Veterinary Research Institute; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Texl","sequence":"additional","affiliation":[{"name":"Sanatorium HELIOS; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rubes","sequence":"additional","affiliation":[{"name":"Department of Genetics and Reproduction; Veterinary Research Institute; Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"10.1111\/and.12156-BIB0001|and12156-cit-0001","first-page":"81","article-title":"Value of DNA integrity assays for fertility evaluation","volume":"65","author":"Aitken","year":"2007","journal-title":"Soc Reprod Fertil Suppl"},{"key":"10.1111\/and.12156-BIB0002|and12156-cit-0002","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/432048a","article-title":"Seeds of concern","volume":"432","author":"Aitken","year":"2004","journal-title":"Nature"},{"key":"10.1111\/and.12156-BIB0003|and12156-cit-0003","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0015-0282(16)32643-7","article-title":"Spermatozoa velocities in vitro. A simple method of measurement","volume":"8","author":"Baker","year":"1957","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0004|and12156-cit-0004","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1439-0272.1990.tb01934.x","article-title":"Round-headed spermatozoa: a model to study the role of the acrosome in early events of gamete interaction","volume":"22","author":"Bernhardi","year":"1990","journal-title":"Andrologia"},{"key":"10.1111\/and.12156-BIB0005|and12156-cit-0005","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.urology.2010.12.015","article-title":"Analysis of sperm aneuploidies and DNA fragmentation in patients with globozoospermia or with abnormal acrosomes","volume":"77","author":"Brahem","year":"2011","journal-title":"Urology"},{"key":"10.1111\/and.12156-BIB0006|and12156-cit-0006","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/jrf.0.1050025","article-title":"Identification of male germ cells undergoing apoptosis in adult rats","volume":"105","author":"Brinkworth","year":"1995","journal-title":"J Reprod Fertil"},{"key":"10.1111\/and.12156-BIB0007|and12156-cit-0007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/humrep\/del326","article-title":"Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome","volume":"22","author":"Bungum","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0008|and12156-cit-0008","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(98)00498-1","article-title":"Characterization of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection","volume":"71","author":"Carrell","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0009|and12156-cit-0009","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0015-0282(01)02904-1","article-title":"Chromosome 15 aneuploidy in the sperm and conceptus of a sibling with variable familial expression of round-headed sperm syndrome","volume":"76","author":"Carrell","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0010|and12156-cit-0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jemt.10317","article-title":"Expression of mammalian spermatozoal nucleoproteins","volume":"61","author":"Dadoune","year":"2003","journal-title":"Microsc Res Tech"},{"key":"10.1111\/and.12156-BIB0011|and12156-cit-0011","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0015-0282(16)56528-5","article-title":"A morphological and functional study of fusibility in round-headed spermatozoa in the human","volume":"61","author":"Dale","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0012|and12156-cit-0012","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/humupd\/dml047","article-title":"Globozoospermia revisited","volume":"13","author":"Dam","year":"2007","journal-title":"Hum Reprod Update"},{"key":"10.1111\/and.12156-BIB0013|and12156-cit-0013","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cyto.a.10015","article-title":"Toluidine blue test for sperm DNA integrity and elaboration of image cytometry algorithm","volume":"52","author":"Erenpreisa","year":"2003","journal-title":"Cytometry A"},{"key":"10.1111\/and.12156-BIB0014|and12156-cit-0014","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.fertnstert.2007.10.066","article-title":"Data analysis of two in vivo fertility studies using Sperm Chromatin Structure Assay-derived DNA fragmentation index vs. pregnancy outcome","volume":"90","author":"Evenson","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0015|and12156-cit-0015","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/humrep\/14.4.1039","article-title":"Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic","volume":"14","author":"Evenson","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0016|and12156-cit-0016","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.fertnstert.2007.02.022","article-title":"Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation","volume":"89","author":"Frydman","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0017|and12156-cit-0017","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/humrep\/dei029","article-title":"Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI","volume":"20","author":"Heindryckx","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0018|and12156-cit-0018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0028-1106747","article-title":"Round headed spermatozoa: a cause of male infertility","volume":"98","author":"Holstein","year":"1973","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1111\/and.12156-BIB0019|and12156-cit-0019","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/S0015-0282(03)00402-3","article-title":"Hyaluronic acid binding by human sperm indicates cellular maturity, viability, and unreacted acrosomal status","volume":"79","author":"Huszar","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0020|and12156-cit-0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1439-0272.1985.tb00956.x","article-title":"Acrosomeless sperm. A cause of primary male infertility","volume":"17","author":"Jeyendran","year":"1985","journal-title":"Andrologia"},{"key":"10.1111\/and.12156-BIB0021|and12156-cit-0021","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.fertnstert.2004.03.064","article-title":"Evaluation and treatment of familial globozoospermia in five brothers","volume":"82","author":"Kilani","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0022|and12156-cit-0022","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0015-0282(16)49891-2","article-title":"Sperm morphologic features as a prognostic factor in in vitro fertilization","volume":"46","author":"Kruger","year":"1986","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0023|and12156-cit-0023","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/327077a0","article-title":"Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues","volume":"327","author":"Kuchino","year":"1987","journal-title":"Nature"},{"key":"10.1111\/and.12156-BIB0024|and12156-cit-0024","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/mrd.1120190404","article-title":"Fertilizing potential of acrosome-defective sperm following microsurgical injection into eggs","volume":"19","author":"Lanzendorf","year":"1988","journal-title":"Gamete Res"},{"key":"10.1111\/and.12156-BIB0025|and12156-cit-0025","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/oxfordjournals.humrep.a136000","article-title":"Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia","volume":"10","author":"Liu","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0026|and12156-cit-0026","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0015-0282(16)57197-0","article-title":"Fertilization and pregnancy after intracytoplasmic microinjection of acrosomeless spermatozoa","volume":"62","author":"Lundin","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0027|and12156-cit-0027","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000086910","article-title":"Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes:teratozoospermia","volume":"111","author":"Machev","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1111\/and.12156-BIB0028|and12156-cit-0028","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/humrep\/dem395","article-title":"The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?","volume":"23","author":"Nicopoullos","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0029|and12156-cit-0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0272.2012.01308.x","article-title":"Molecular cytogenetic and genetic aspects of globozoospermia: a review","volume":"45","author":"Perrin","year":"2013","journal-title":"Andrologia"},{"key":"10.1111\/and.12156-BIB0030|and12156-cit-0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000086893","article-title":"Individual variation in the frequency of sperm aneuploidy in humans","volume":"111","author":"Rubes","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"10.1111\/and.12156-BIB0031|and12156-cit-0031","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/humrep\/16.10.2084","article-title":"Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome","volume":"16","author":"Rubio","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0032|and12156-cit-0032","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1439-0272.2008.00905.x","article-title":"Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples","volume":"41","author":"Rybar","year":"2009","journal-title":"Andrologia"},{"key":"10.1111\/and.12156-BIB0033|and12156-cit-0033","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0015-0282(97)00378-6","article-title":"Fertilization and pregnancy after assisted oocyte activation and intracytoplasmic sperm injection in a case of round-headed sperm associated with deficient oocyte activation capacity","volume":"68","author":"Rybouchkin","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0034|and12156-cit-0034","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1093\/humrep\/der258","article-title":"Successful childbirth after intracytoplasmic morphologically selected sperm injection without assisted oocyte activation in a patient with globozoospermia","volume":"26","author":"Sermondade","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0035|and12156-cit-0035","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1095\/biolreprod56.3.602","article-title":"Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro","volume":"56","author":"Sun","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12156-BIB0036|and12156-cit-0036","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1464-410X.1985.tb06320.x","article-title":"Round headed sperm","volume":"57","author":"Sutherland","year":"1985","journal-title":"Br J Urol"},{"key":"10.1111\/and.12156-BIB0037|and12156-cit-0037","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.rbmo.2009.12.024","article-title":"Complete globozoospermia associated with PLC\u03b6 deficiency treated with calcium ionophore and ICSI results in pregnancy","volume":"20","author":"Taylor","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1111\/and.12156-BIB0038|and12156-cit-0038","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1093\/humrep\/17.8.2128","article-title":"Globozoospermia is associated with chromatin structure abnormalities: case report","volume":"17","author":"Vicari","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12156-BIB0039|and12156-cit-0039","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1016006509036","article-title":"Sperm single-stranded DNA, detected by acridine orange staining, reduces fertilization and quality of ICSI-derived embryos","volume":"19","author":"Virant-Klun","year":"2002","journal-title":"J Assist Reprod Genet"},{"key":"10.1111\/and.12156-BIB0040|and12156-cit-0040","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.fertnstert.2003.09.063","article-title":"Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles","volume":"81","author":"Virro","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12156-BIB0041|and12156-cit-0041","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010","edition":"5"},{"key":"10.1111\/and.12156-BIB0042|and12156-cit-0042","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1172\/JCI36942","article-title":"Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development","volume":"118","author":"Yoon","year":"2008","journal-title":"J Clin Invest"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12156","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12156\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:35:28Z","timestamp":1671539728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,6]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12156","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9,6]]}}}