{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:48:08Z","timestamp":1785448088304,"version":"3.56.0"},"reference-count":53,"publisher":"Hindawi Limited","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":721,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1111\/and.12159","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T10:56:40Z","timestamp":1378897000000},"page":"848-858","source":"Crossref","is-referenced-by-count":34,"title":["Quercetin attenuates carbon tetrachloride-induced testicular damage in rats"],"prefix":"10.1155","volume":"46","author":[{"given":"M.","family":"S\u00f6nmez","sequence":"first","affiliation":[{"name":"Department of Reproduction and Artificial Insemination; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"T\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"\u00c7eriba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"\u00c7ift\u00e7i","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Diseases; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Y\u00fcce","sequence":"additional","affiliation":[{"name":"Department of Physiology; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"G\u00fcven\u00e7","sequence":"additional","affiliation":[{"name":"Department of Physiology; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e.","family":"\u00d6zer Kaya","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"\u00c7ay","sequence":"additional","affiliation":[{"name":"Department of Physiology; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aksakal","sequence":"additional","affiliation":[{"name":"Department of Physiology; Faculty of Veterinary Medicine; Firat University; Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2013,9,10]]},"reference":[{"key":"10.1111\/and.12159-BIB0001|and12159-cit-0001","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1365-2605.2011.01239.x","article-title":"The protective effects of quercetin on the cytotoxicity of atrazine on rat Sertoli-germ cell co-culture","volume":"35","author":"Abarikwu","year":"2012","journal-title":"Int J Androl"},{"key":"10.1111\/and.12159-BIB0002|and12159-cit-0002","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.5897\/JMPR12.217","article-title":"Effect of pomegranate pretreatment on genotoxicity and hepatotoxicity induced by carbon tetrachloride (CCl4) in male rats","volume":"6","author":"Abdou","year":"2012","journal-title":"J Med Plants Res"},{"key":"10.1111\/and.12159-BIB0003|and12159-cit-0003","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0009-8981(99)00140-0","article-title":"Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication","volume":"289","author":"Abraham","year":"1999","journal-title":"Clin Chim Acta"},{"key":"10.1111\/and.12159-BIB0004|and12159-cit-0004","first-page":"276","volume-title":"Methods in Enzymatic Analysis","author":"Aebi","year":"1983"},{"key":"10.1111\/and.12159-BIB0005|and12159-cit-0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4161\/oxim.1.1.6843","article-title":"Antioxidant systems and oxidative stress in the testes","volume":"1","author":"Aitken","year":"2008","journal-title":"Oxid Med Cell Longev"},{"key":"10.1111\/and.12159-BIB0006|and12159-cit-0006","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1439-0272.2010.01063.x","article-title":"Antioxidative potential of quercetin against hydrogen peroxide induced oxidative stress in spermatozoa in vitro","volume":"43","author":"Ben Abdallah","year":"2011","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0007|and12159-cit-0007","article-title":"Quercetin attenuates lambda cyhalothrin-induced reproductive toxicity in male rats","author":"Ben Abdallah","year":"2012","journal-title":"Environ Toxicol"},{"key":"10.1111\/and.12159-BIB0008|and12159-cit-0008","first-page":"299","volume-title":"Reproduction and Breeding Techniques for Laboratory Animals","author":"Bennett","year":"1970"},{"key":"10.1111\/and.12159-BIB0009|and12159-cit-0009","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1365-2605.1998.00133.x","article-title":"A matter of death and life: the significance of germ cell death during spermatogenesis","volume":"21","author":"Blanco-Rodriguez","year":"1998","journal-title":"Int J Androl"},{"key":"10.1111\/and.12159-BIB0010|and12159-cit-0010","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3748\/wjg.v10.i17.2529","article-title":"Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1","volume":"10","author":"Castilla-Cortazar","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1111\/and.12159-BIB0011|and12159-cit-0011","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1439-0272.2010.01126.x","article-title":"Quercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin induced testicular damage in rats","volume":"44","author":"Ciftci","year":"2012","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0012|and12159-cit-0012","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1002\/ptr.793","article-title":"Effects of black tea extract on carbon tetrachloride-induced lipid peroxidation in liver, kidneys, and testes of rats","volume":"16","author":"Fadhel","year":"2002","journal-title":"Phytother Res"},{"key":"10.1111\/and.12159-BIB0013|and12159-cit-0013","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/and.12001","article-title":"Quercetin exacerbates the effects of subacute treatment of atrazine on reproductive tissue antioxidant defence system, lipid peroxidation and sperm quality in rats","volume":"45","author":"Farombi","year":"2013","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0014|and12159-cit-0014","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1439-0272.2012.01279.x","article-title":"Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats","volume":"44","author":"Farombi","year":"2012a","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0015|and12159-cit-0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1515\/jbcpp-2011-0029","article-title":"Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulphate in rats","volume":"23","author":"Farombi","year":"2012b","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10.1111\/and.12159-BIB0016|and12159-cit-0016","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1590\/S1677-55382006000100016","article-title":"Seminiferous epithelium of rats with food restriction and carbon tetrachloride induced cirrhosis","volume":"32","author":"Horn","year":"2006","journal-title":"Int Brazilian J Urol"},{"key":"10.1111\/and.12159-BIB0017|and12159-cit-0017","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/carcin\/22.5.763","article-title":"Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas","volume":"22","author":"Hudson","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1111\/and.12159-BIB0018|and12159-cit-0018","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1271\/bbb.70705","article-title":"Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles","volume":"72","author":"Izawa","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1111\/and.12159-BIB0019|and12159-cit-0019","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1006\/bbrc.1998.8665","article-title":"The detection of cytochrome P450 2E1 and its catalytic activity in rat testis","volume":"246","author":"Jiang","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/and.12159-BIB0020|and12159-cit-0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000178170","article-title":"Testicular biopsy score count a method for registration of spermatogenesis in human normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1111\/and.12159-BIB0021|and12159-cit-0021","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000144399","article-title":"Effect of carbon tetrachloride on gonadal physiology in male rats","volume":"91","author":"Kalla","year":"1975","journal-title":"Acta Anat (Basel)"},{"key":"10.1111\/and.12159-BIB0022|and12159-cit-0022","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.fct.2011.11.051","article-title":"Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis","volume":"50","author":"Kanter","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/and.12159-BIB0023|and12159-cit-0023","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1095\/biolreprod59.4.890","article-title":"Rat epididymal sperm quantity, quality, and transit time after guanethidine-induced sympathectomy","volume":"59","author":"Kempinas","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12159-BIB0024|and12159-cit-0024","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/ptr.3100","article-title":"Beneficial effects of quercetin on sperm parameters in streptozotocin-induced diabetic male rats","volume":"24","author":"Khaki","year":"2010","journal-title":"Phytother Res"},{"key":"10.1111\/and.12159-BIB0025|and12159-cit-0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1476-511X-11-103","article-title":"Protective effects of Launaea procumbens on rat testis damage by CCl4","volume":"11","author":"Khan","year":"2012","journal-title":"Lipids Health Dis"},{"key":"10.1111\/and.12159-BIB0026|and12159-cit-0026","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.fct.2009.03.020","article-title":"Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat","volume":"47","author":"Khan","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/and.12159-BIB0027|and12159-cit-0027","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1439-0272.2001.00432.x","article-title":"Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation","volume":"33","author":"Khanduja","year":"2001","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0028|and12159-cit-0028","first-page":"553","volume-title":"Reproductive and Developmental Toxicology","author":"Klinefelter","year":"1998"},{"key":"10.1111\/and.12159-BIB0029|and12159-cit-0029","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/and.12159-BIB0030|and12159-cit-0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2164\/jandrol.106.002006","article-title":"Abnormal morphology of spermatozoa in cytochrome P450 17alpha-hydroxylase\/17, 20-lyase (CYP17) deficient mice","volume":"28","author":"Liu","year":"2007","journal-title":"J Androl"},{"key":"10.1111\/and.12159-BIB0031|and12159-cit-0031","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1111\/and.12159-BIB0032|and12159-cit-0032","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1742-4658.2008.06831.x","article-title":"Pathways involved in testicular germ cell apoptosis induced by H2O2 in vitro","volume":"276","author":"Maheshwari","year":"2009","journal-title":"FEBS J"},{"key":"10.1111\/and.12159-BIB0033|and12159-cit-0033","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10590500701569398","article-title":"Postulated carbon tetrachloride mode of action: a review","volume":"25","author":"Manibusan","year":"2007","journal-title":"J Environ Sci Health Part C"},{"key":"10.1111\/and.12159-BIB0034|and12159-cit-0034","first-page":"514","article-title":"Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes CCL4 induced hepatotoxic rats","volume":"46","author":"Manjrekar","year":"2008","journal-title":"Indian J Exp Biol"},{"key":"10.1111\/and.12159-BIB0035|and12159-cit-0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.reprotox.2012.10.002","article-title":"Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm","volume":"34","author":"Moretti","year":"2012","journal-title":"Reprod Toxicol"},{"key":"10.1111\/and.12159-BIB0036|and12159-cit-0036","first-page":"57","article-title":"Protective efficiency of caffeic acid phenethyl ester in carbon tetracloride-induced experimental lung injury (Article in Turkish)","volume":"23","author":"\u00d6get\u00fcrk","year":"2009","journal-title":"F\u0131rat Unv J Health Sci"},{"key":"10.1111\/and.12159-BIB0037|and12159-cit-0037","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1023\/A:1022869716643","article-title":"Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis","volume":"48","author":"Pavanato","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1111\/and.12159-BIB0038|and12159-cit-0038","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1007\/s10620-007-9748-x","article-title":"Quercetin prevents oxidative stress in cirrhotic rats","volume":"52","author":"Pavanato","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1111\/and.12159-BIB0039|and12159-cit-0039","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","article-title":"Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems","volume":"16","author":"Placer","year":"1966","journal-title":"Anal Biochem"},{"key":"10.1111\/and.12159-BIB0040|and12159-cit-0040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1439-0272.2012.01311.x","article-title":"Quercetin impairs the reproductive potential of male mice","volume":"45","author":"Ranawat","year":"2013a","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0041|and12159-cit-0041","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ptr.4799","article-title":"A new perspective on the quercetin paradox in male reproductive dysfunction","volume":"27","author":"Ranawat","year":"2013b","journal-title":"Phytother Res"},{"key":"10.1111\/and.12159-BIB0042|and12159-cit-0042","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal Biochem"},{"key":"10.1111\/and.12159-BIB0043|and12159-cit-0043","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(01)00473-5","article-title":"Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants","volume":"169","author":"Sheweita","year":"2001","journal-title":"Toxicology"},{"key":"10.1111\/and.12159-BIB0044|and12159-cit-0044","first-page":"888","article-title":"Protective and curative effects of the 15 KD isolated protein from the Peganum harmala L. seeds against carbon tetrachloride induced oxidative stress in brain, testes and erythrocytes of rats","volume":"15","author":"Soliman","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1111\/and.12159-BIB0045|and12159-cit-0045","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1745-7262.2008.00306.x","article-title":"Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats","volume":"10","author":"Taepongsorat","year":"2008","journal-title":"Asian J Androl"},{"key":"10.1111\/and.12159-BIB0046|and12159-cit-0046","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.clnu.2007.12.006","article-title":"Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats","volume":"27","author":"T\u00fcrk","year":"2008","journal-title":"Clin Nutr"},{"key":"10.1111\/and.12159-BIB0047|and12159-cit-0047","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.phymed.2010.07.008","article-title":"Lycopene and ellagic acid prevent testicular apoptosis induced by cisplatin","volume":"18","author":"T\u00fcrk","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1111\/and.12159-BIB0048|and12159-cit-0048","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J Androl"},{"key":"10.1111\/and.12159-BIB0049|and12159-cit-0049","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2003.10.069","article-title":"Antioxidant strategies in the epididymis","volume":"216","author":"Vernet","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1111\/and.12159-BIB0050|and12159-cit-0050","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1095\/biolreprod.107.060558","article-title":"Polyunsaturated fatty acids in male and female reproduction","volume":"77","author":"Wathes","year":"2007","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12159-BIB0051|and12159-cit-0051","article-title":"Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on male reproductive system","author":"Y\u00fcce","year":"2013","journal-title":"Andrologia"},{"key":"10.1111\/and.12159-BIB0052|and12159-cit-0052","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/toxsci\/kfi333","article-title":"Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells","volume":"88","author":"Zhang","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1111\/and.12159-BIB0053|and12159-cit-0053","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.cryobiol.2012.09.003","article-title":"Effect of freezing-thawing process and quercetin on human sperm survival and DNA integrity","volume":"65","author":"Zribi","year":"2012","journal-title":"Cryobiology"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12159","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12159\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:35:29Z","timestamp":1671539729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,10]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12159","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9,10]]}}}