{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:37:59Z","timestamp":1792658279745,"version":"4.5.0"},"reference-count":34,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":365,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1111\/and.12345","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T05:16:13Z","timestamp":1411103773000},"page":"n\/a-n\/a","source":"Crossref","is-referenced-by-count":24,"title":["Effect of varicocelectomy on sperm functional characteristics and DNA methylation"],"prefix":"10.1155","author":[{"given":"M.","family":"Tavalaee","sequence":"first","affiliation":[{"name":"Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center; Royan Institute for Biotechnology, ACECR; Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bahreinian","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center; Royan Institute for Biotechnology, ACECR; Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Barekat","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center; Royan Institute for Biotechnology, ACECR; Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Isfahan Fertility and Infertility Center; Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Nasr-Esfahani","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center; Royan Institute for Biotechnology, ACECR; Isfahan Iran"},{"name":"Isfahan Fertility and Infertility Center; Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"10.1111\/and.12345-BIB0001|and12345-cit-0001","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.urology.2007.04.011","article-title":"Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach","volume":"70","author":"Agarwal","year":"2007","journal-title":"Urology"},{"key":"10.1111\/and.12345-BIB0002|and12345-cit-0002","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10815-007-9177-y","article-title":"Mammalian sperm chromatin structure and assessment of DNA fragmentation","volume":"24","author":"Andrabi","year":"2007","journal-title":"J Assist Reprod Genet"},{"key":"10.1111\/and.12345-BIB0003|and12345-cit-0003","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/humrep\/deh684","article-title":"Influence of global sperm DNA methylation on IVF results","volume":"20","author":"Benchaib","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12345-BIB0004|and12345-cit-0004","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fertnstert.2011.12.036","article-title":"Epigenetics of the male gamete","volume":"97","author":"Carrell","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12345-BIB0005|and12345-cit-0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","article-title":"Epigenetics in human disease and prospects for epigenetic therapy","volume":"429","author":"Egger","year":"2004","journal-title":"Nature"},{"key":"10.1111\/and.12345-BIB0006|and12345-cit-0006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0970-1591.78428","article-title":"Varicocele-induced infertility: newer insights into its pathophysiology","volume":"27","author":"Eisenberg","year":"2011","journal-title":"Indian J Urol"},{"key":"10.1111\/and.12345-BIB0007|and12345-cit-0007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1745-7262.2006.00112.x","article-title":"Sperm chromatin structure and male fertility: biological and clinical aspects","volume":"8","author":"Erenpreiss","year":"2006","journal-title":"Asian J Androl"},{"key":"10.1111\/and.12345-BIB0008|and12345-cit-0008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrurol.2012.198","article-title":"Insight into oxidative stress in varicocele-associated male infertility: part 2","volume":"10","author":"Hamada","year":"2013","journal-title":"Nat Rev Urol"},{"key":"10.1111\/and.12345-BIB0009|and12345-cit-0009","doi-asserted-by":"crossref","first-page":"e1289","DOI":"10.1371\/journal.pone.0001289","article-title":"Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm","volume":"2","author":"Houshdaran","year":"2007","journal-title":"PLoS One"},{"key":"10.1111\/and.12345-BIB0010|and12345-cit-0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1203\/01.PDR.0000179401.17161.D3","article-title":"Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies","volume":"58","author":"Jacob","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1111\/and.12345-BIB0011|and12345-cit-0011","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1530\/REP-11-0450","article-title":"The sperm epigenome and potential implications for the developing embryo","volume":"143","author":"Jenkins","year":"2012","journal-title":"Reproduction"},{"key":"10.1111\/and.12345-BIB0012|and12345-cit-0012","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1111\/and.12345-BIB0013|and12345-cit-0013","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02633","article-title":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting","volume":"429","author":"Kaneda","year":"2004","journal-title":"Nature"},{"key":"10.1111\/and.12345-BIB0014|and12345-cit-0014","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/j.1939-4640.2003.tb03133.x","article-title":"5-Aza-2\u2032-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome","volume":"24","author":"Kelly","year":"2003","journal-title":"J Androl"},{"key":"10.1111\/and.12345-BIB0015|and12345-cit-0015","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/humrep\/dep088","article-title":"Selection of sperm based on combined density gradient and Zeta method may improve ICSI outcome","volume":"24","author":"Kheirollahi-Kouhestani","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12345-BIB0016|and12345-cit-0016","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/19396368.2012.681420","article-title":"DHR123: an alternative probe for assessment of ROS in human spermatozoa","volume":"58","author":"Kiani-Esfahani","year":"2012","journal-title":"Syst Biol Reprod Med"},{"key":"10.1111\/and.12345-BIB0017|and12345-cit-0017","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/hmg\/ddm187","article-title":"Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients","volume":"16","author":"Kobayashi","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1111\/and.12345-BIB0018|and12345-cit-0018","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1038\/ncomms3889","article-title":"Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes","volume":"4","author":"Lambrot","year":"2013","journal-title":"Nat Commun"},{"key":"10.1111\/and.12345-BIB0019|and12345-cit-0019","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/abbs\/gmq015","article-title":"DNA methyltransferase and methyl-binding proteins of mammals","volume":"42","author":"Lan","year":"2010","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1111\/and.12345-BIB0020|and12345-cit-0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/molehr\/gam093","article-title":"Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia","volume":"14","author":"Marques","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"10.1111\/and.12345-BIB0021|and12345-cit-0021","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.4161\/epi.6.11.17993","article-title":"DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stages","volume":"6","author":"Marques","year":"2011","journal-title":"Epigenetics"},{"key":"10.1111\/and.12345-BIB0022|and12345-cit-0022","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.99.3.371","article-title":"Temporal and regional changes in DNA methylation in the embryonic, extra embryonic and germ cell lineages during mouse embryo development","volume":"99","author":"Monk","year":"1987","journal-title":"Development"},{"key":"10.1111\/and.12345-BIB0023|and12345-cit-0023","first-page":"141","article-title":"Origin and role of DNA damage in varicocele","volume":"6","author":"Nasr Esfahani","year":"2012","journal-title":"Int J Fertil Steril"},{"key":"10.1111\/and.12345-BIB0024|and12345-cit-0024","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1009412130417","article-title":"Relation between different human sperm nuclear maturity tests and in vitro fertilization","volume":"18","author":"Nasr-Esfahani","year":"2001","journal-title":"J Assist Reprod Genet"},{"key":"10.1111\/and.12345-BIB0025|and12345-cit-0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2605.2007.00822.x","article-title":"Varicocelectomy: semen parameters and protamine deficiency","volume":"32","author":"Nasr-Esfahani","year":"2009","journal-title":"Int J Androl"},{"key":"10.1111\/and.12345-BIB0026|and12345-cit-0026","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1439-0272.2011.01242.x","article-title":"High total acrosin activity in varicocele individuals","volume":"44","author":"Navaeian-Kalat","year":"2011","journal-title":"Andrologia"},{"key":"10.1111\/and.12345-BIB0027|and12345-cit-0027","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1124\/jpet.107.121699","article-title":"Adverse effects of 5-aza-2\u2032-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation","volume":"322","author":"Oakes","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/and.12345-BIB0028|and12345-cit-0028","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0955-0674(00)00208-8","article-title":"Histone methylation versus histone acetylation: new insights into epigenetic regulation","volume":"13","author":"Rice","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"10.1111\/and.12345-BIB0500|and12345-cit-0500","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/humrep\/dei429","article-title":"Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress","volume":"21","author":"Smith","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1111\/and.12345-BIB0029|and12345-cit-0029","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.fertnstert.2008.01.063","article-title":"Influence of sperm chromatin anomalies on assisted reproductive technology outcome","volume":"91","author":"Tavalaee","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12345-BIB0030|and12345-cit-0030","first-page":"165","article-title":"Semen parameters and chromatin packaging in microsurgical varicocelectomy patients","volume":"6","author":"Tavalaee","year":"2012","journal-title":"Int J Fertil Steril"},{"key":"10.1111\/and.12345-BIB0031|and12345-cit-0031","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J Assist Reprod Genet"},{"key":"10.1111\/and.12345-BIB0032|and12345-cit-0032","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"},{"key":"10.1111\/and.12345-BIB0033|and12345-cit-0033","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2605.2009.01048.x","article-title":"Effect of microsurgical varicocelectomy on human sperm chromatin and DNA integrity: a prospective trial","volume":"34","author":"Zini","year":"2011","journal-title":"Int J Androl"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12345","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12345\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:35:41Z","timestamp":1671539741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1111\/and.12345","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}