{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:13:31Z","timestamp":1790612011513,"version":"4.1.0"},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":335,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1111\/and.12363","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T01:21:48Z","timestamp":1413940908000},"page":"n\/a-n\/a","source":"Crossref","is-referenced-by-count":16,"title":["Roles of adrenomedullin and hypoxia-inducible factor 1 alpha in patients with varicocele"],"prefix":"10.1155","author":[{"given":"W.","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Urology; Renmin Hospital of Wuhan University; Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.-H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics; Renmin Hospital of Wuhan University; Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.-B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology; Renmin Hospital of Wuhan University; Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-G.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology; Renmin Hospital of Wuhan University; Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology; Renmin Hospital of Wuhan University; Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"10.1111\/and.12363-BIB0001|and12363-cit-0001","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrurol.2012.197","article-title":"Insight into oxidative stress in varicocele-associated male infertility: part 1","volume":"9","author":"Agarwal","year":"2012","journal-title":"Nat Rev Urol"},{"key":"10.1111\/and.12363-BIB0002|and12363-cit-0002","first-page":"5","article-title":"Adrenomedullin-what do we know 10\u00a0years since its discovery?","volume":"56","author":"Beltowski","year":"2004","journal-title":"Pol J Pharmacol"},{"key":"10.1111\/and.12363-BIB0003|and12363-cit-0003","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cmet.2005.05.002","article-title":"Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation","volume":"1","author":"Brunelle","year":"2005","journal-title":"Cell Metab"},{"key":"10.1111\/and.12363-BIB0004|and12363-cit-0004","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1095\/biolreprod.107.060871","article-title":"Adrenomedullin in the rat testis. I: its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell","volume":"78","author":"Chan","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12363-BIB0005|and12363-cit-0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11934-013-0339-4","article-title":"Varicocele and hypogonadism","volume":"14","author":"Dabaja","year":"2013","journal-title":"Curr Urol Rep"},{"key":"10.1111\/and.12363-BIB0006|and12363-cit-0006","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/14728222.2010.522328","article-title":"Adrenomedullin as a therapeutic target in angiogenesis","volume":"14","author":"Deville","year":"2010","journal-title":"Expert Opin Ther Targets"},{"key":"10.1111\/and.12363-BIB0007|and12363-cit-0007","first-page":"741","article-title":"Varicocele in adolescents","volume":"63","author":"Dobanovacki","year":"2010","journal-title":"Med Pregl"},{"key":"10.1111\/and.12363-BIB0008|and12363-cit-0008","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1111\/and.12363-BIB0009|and12363-cit-0009","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/01.HYP.0000165690.85505.37","article-title":"Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain","volume":"45","author":"Fujita","year":"2005","journal-title":"Hypertension"},{"key":"10.1111\/and.12363-BIB0010|and12363-cit-0010","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1210\/me.2006-0156","article-title":"Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling","volume":"21","author":"Gibbons","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1111\/and.12363-BIB0011|and12363-cit-0011","first-page":"2697","article-title":"Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells","volume":"22","author":"Horiuchi","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1111\/and.12363-BIB0012|and12363-cit-0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/2277-9175.124647","article-title":"Determination of the best position and site for color Doppler ultrasonographic evaluation of the testicular vein to define the clinical grades of varicocele ultrasonographically","volume":"3","author":"Karami","year":"2014","journal-title":"Adv Biomed Res"},{"key":"10.1111\/and.12363-BIB0013|and12363-cit-0013","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1124\/mol.106.027029","article-title":"Hypoxia-inducible factor-1 (HIF-1)","volume":"70","author":"Ke","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1111\/and.12363-BIB0014|and12363-cit-0014","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/01.ju.0000135455.97627.15","article-title":"Experimental varicocele induces hypoxia inducible factor-1alpha, vascular endothelial growth factor expression and angiogenesis in the rat testis","volume":"172","author":"Kilinc","year":"2004","journal-title":"J Urol"},{"key":"10.1111\/and.12363-BIB0015|and12363-cit-0015","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbrc.2012.08.022","article-title":"Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma 1993","volume":"425","author":"Kitamura","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/and.12363-BIB0016|and12363-cit-0016","first-page":"1","article-title":"Anxiety disorders are associated with increased plasma adrenomedullin level and left ventricular hypertrophy in patients with hypertension","author":"Kong","year":"2013","journal-title":"Clin Exp Hypertens"},{"key":"10.1111\/and.12363-BIB0017|and12363-cit-0017","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0022-5347(05)00417-9","article-title":"Increased expression of hypoxia-inducible factor-1alpha in the internal spermatic vein of patients with varicocele","volume":"175","author":"Lee","year":"2006","journal-title":"J Urol"},{"key":"10.1111\/and.12363-BIB0018|and12363-cit-0018","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1095\/biolreprod.106.052274","article-title":"Adrenomedullin peptide: gene expression of adrenomedullin, its receptors and receptor activity modifying proteins, and receptor binding in rat testis-actions on testosterone secretion","volume":"75","author":"Li","year":"2006","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12363-BIB0019|and12363-cit-0019","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00345-004-0421-0","article-title":"Color Doppler ultrasound investigation of varicocele","volume":"22","author":"Liguori","year":"2004","journal-title":"World J Urol"},{"key":"10.1111\/and.12363-BIB0020|and12363-cit-0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejogrb.2005.03.021","article-title":"Adrenomedullin in human male reproductive system","volume":"122","author":"Marinoni","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1111\/and.12363-BIB0021|and12363-cit-0021","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1046\/j.1464-410X.2000.00853.x","article-title":"The role of adrenomedullin in varicocele and impotence","volume":"86","author":"Ozbek","year":"2000","journal-title":"BJU Int"},{"key":"10.1111\/and.12363-BIB0022|and12363-cit-0022","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.acuro.2011.07.022","article-title":"Increased expression of hypoxia-inducible factor-1alpha and connective tissue growth factor accompanied by fibrosis in the rat testis of varicocele","volume":"36","author":"Paick","year":"2012","journal-title":"Actas Urol Esp"},{"key":"10.1111\/and.12363-BIB0023|and12363-cit-0023","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"10.1111\/and.12363-BIB0024|and12363-cit-0024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012513-104720","article-title":"Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology","volume":"9","author":"Semenza","year":"2014","journal-title":"Annu Rev Pathol"},{"key":"10.1111\/and.12363-BIB0025|and12363-cit-0025","first-page":"1670","article-title":"Expression of hypoxia induced factor-1alpha and function of epididymis in varicocele: experiment with rats","volume":"88","author":"Wang","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1111\/and.12363-BIB0026|and12363-cit-0026","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2164\/jandrol.108.007153","article-title":"Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele","volume":"31","author":"Wang","year":"2010","journal-title":"J Androl"},{"key":"10.1111\/and.12363-BIB0027|and12363-cit-0027","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.fertnstert.2011.01.002","article-title":"The great debate: varicocele treatment and impact on fertility","volume":"95","author":"Will","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12363-BIB0028|and12363-cit-0028","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/tox.20430","article-title":"Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats","volume":"24","author":"Yurekli","year":"2009","journal-title":"Environ Toxicol"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12363\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:35:44Z","timestamp":1671539744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1111\/and.12363","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}