{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:29:43Z","timestamp":1776263383162,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872572"],"award-info":[{"award-number":["30872572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1111\/and.12518","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T14:31:04Z","timestamp":1452781864000},"page":"824-828","source":"Crossref","is-referenced-by-count":3,"title":["Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction"],"prefix":"10.1155","volume":"48","author":[{"given":"Z.-Y.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-L.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.-H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.-J.","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.-J.","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-B.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Urology; First Affiliated Hospital of Yangtze University; Jingzhou HuBei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"10.1111\/and.12518-BIB0001|and12518-cit-0001","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/sj.ijir.3901190","article-title":"Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation","volume":"16","author":"Bochinski","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1111\/and.12518-BIB0002|and12518-cit-0002","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0022-5347(05)67138-8","article-title":"Hypertension is associated with severe erectile dysfunction","volume":"164","author":"Burchardt","year":"2000","journal-title":"J Urol"},{"key":"10.1111\/and.12518-BIB0003|and12518-cit-0003","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/S0022-5347(05)00309-5","article-title":"Erectile dysfunction","volume":"175","author":"Burnett","year":"2006","journal-title":"J Urol"},{"key":"10.1111\/and.12518-BIB0004|and12518-cit-0004","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","article-title":"Expression, regulation,\u00a0and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels","volume":"24","author":"Delafontaine","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/and.12518-BIB0005|and12518-cit-0005","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1097\/01.hjh.0000251898.40002.5b","article-title":"Female sexual dysfunction in essential hypertension: a common problem being uncovered","volume":"24","author":"Doumas","year":"2006","journal-title":"J Hypertens"},{"key":"10.1111\/and.12518-BIB0006|and12518-cit-0006","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.ijir.3901519","article-title":"A retrospective study of the relationship between biomarkers of atherosclerosis and erectile dysfunction in 988 men","volume":"19","author":"Eaton","year":"2007","journal-title":"Int J Impot Res"},{"key":"10.1111\/and.12518-BIB0007|and12518-cit-0007","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/sj.ijir.3901256","article-title":"Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility","volume":"16","author":"Ghalayini","year":"2004","journal-title":"Int J Impot Res"},{"key":"10.1111\/and.12518-BIB0008|and12518-cit-0008","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.urology.2004.08.059","article-title":"Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both","volume":"64","author":"Giuliano","year":"2004","journal-title":"Urology"},{"key":"10.1111\/and.12518-BIB0009|and12518-cit-0009","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.annepidem.2005.10.007","article-title":"A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study","volume":"16","author":"Hunt","year":"2006","journal-title":"Ann Epidemiol"},{"key":"10.1111\/and.12518-BIB0010|and12518-cit-0010","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1053\/meta.2003.50079","article-title":"Interactive effects of insulin-like growth factor-1 and beta-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells","volume":"52","author":"Isenovic","year":"2003","journal-title":"Metabolism"},{"key":"10.1111\/and.12518-BIB0012|and12518-cit-0012","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.ijir.3900402","article-title":"IGF-1 and TGF-beta2 have a key role on regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in rats","volume":"11","author":"Jung","year":"1999","journal-title":"Int J Impot Res"},{"key":"10.1111\/and.12518-BIB0013|and12518-cit-0013","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0022-5347(05)66158-7","article-title":"Vascular endothelial growth factor promotes proliferation and migration of cavernous smooth muscle cells","volume":"166","author":"Liu","year":"2001","journal-title":"J Urol"},{"key":"10.1111\/and.12518-BIB0014|and12518-cit-0014","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/and.12518-BIB0015|and12518-cit-0015","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0022-5347(05)65986-1","article-title":"Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study","volume":"166","author":"Martin-Morales","year":"2001","journal-title":"J Urol"},{"key":"10.1111\/and.12518-BIB0016|and12518-cit-0016","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00005344-200202000-00006","article-title":"Attenuation of hypertension, cardiomyocyte hypertrophy, and myocardial fibrosis by beta-adrenoceptor blockers in rats under long-term blockade of nitric oxide synthesis","volume":"39","author":"Pacca","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1111\/and.12518-BIB0017|and12518-cit-0017","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.eururo.2004.04.032","article-title":"Intracavernosal injection of vascular endothelial growth factor improves erectile function in aged rats","volume":"46","author":"Park","year":"2004","journal-title":"Eur Urol"},{"key":"10.1111\/and.12518-BIB0018|and12518-cit-0018","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1743-6109.2008.00817.x","article-title":"Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity","volume":"5","author":"Pu","year":"2008","journal-title":"J Sex Med"},{"key":"10.1111\/and.12518-BIB0019|and12518-cit-0019","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.eururo.2004.02.001","article-title":"Regenerative medicine in andrology: tissue engineering and gene therapy as potential treatment options for penile deformations and erectile dysfunction","volume":"46","author":"Schultheiss","year":"2004","journal-title":"Eur Urol"},{"key":"10.1111\/and.12518-BIB0020|and12518-cit-0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.amjmed.2006.06.010","article-title":"Prevalence and risk factors for erectile dysfunction in the US","volume":"120","author":"Selvin","year":"2007","journal-title":"Am J Med"},{"key":"10.1111\/and.12518-BIB0021|and12518-cit-0021","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/01.ju.0000165389.73148.d1","article-title":"Health issues of men: prevalence and correlates of erectile dysfunction","volume":"174","author":"Shabsigh","year":"2005","journal-title":"J Urol"},{"key":"10.1111\/and.12518-BIB0022|and12518-cit-0022","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1743-6109.2007.00440.x","article-title":"Testosterone regulates RhoA\/Rho-kinase signaling in two distinct animal models of chemical diabetes","volume":"4","author":"Vignozzi","year":"2007","journal-title":"J Sex Med"},{"key":"10.1111\/and.12518-BIB0023|and12518-cit-0023","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/HYPERTENSIONAHA.111.179242","article-title":"Circulating vascular growth factors and central hemodynamic load in the community","volume":"59","author":"Zachariah","year":"2012","journal-title":"Hypertension"},{"key":"10.1111\/and.12518-BIB0024|and12518-cit-0024","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/aja.2011.99","article-title":"Increased expression of insulin-like growth factor-binding protein-3 is implicated in erectile dysfunction in two-kidney one-clip hypertensive rats after propranolol treatment","volume":"13","author":"Zhou","year":"2011","journal-title":"Asian J Androl"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12518\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:37:30Z","timestamp":1671539850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,9]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12518","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,14]]}}}