{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:12:56Z","timestamp":1787785976456,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["89-04-117-12493"],"award-info":[{"award-number":["89-04-117-12493"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1111\/and.12568","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T15:41:49Z","timestamp":1462203709000},"page":"1244-1252","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of<i>Crocus sativus<\/i>L. on reduction of cadmium-induced toxicity on spermatogenesis in adult rats"],"prefix":"10.1155","volume":"48","author":[{"given":"A.","family":"Yari","sequence":"first","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Alborz University of Medical Sciences; Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sarveazad","sequence":"additional","affiliation":[{"name":"Colorectal Research Center; Rasoule-e-Akram Hospital; Iran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Embryology and Anatomical Sciences; Faculty of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Raouf Sarshoori","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Baqiyatallah (a.s) University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Babahajian","sequence":"additional","affiliation":[{"name":"Liver & Digestive Research Center; Kurdistan University of Medical Sciences; Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience; Faculty of Advanced Technologies in Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Amidi","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Tehran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bahadoran","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Baqiyatallah (a.s) University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MT.","family":"Joghataei","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center; Faculty of Medicine; Iran University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MH.","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Baqiyatallah (a.s) University of Medical Sciences; Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shams","sequence":"additional","affiliation":[{"name":"Department of Anatomy; Faculty of Medicine; Alborz University of Medical Sciences; Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"10.1111\/and.12568-BIB0001|and12568-cit-0001","first-page":"83","article-title":"Biological effects of saffron","volume":"4","author":"Abdullaev","year":"1993","journal-title":"BioFactors"},{"key":"10.1111\/and.12568-BIB0002|and12568-cit-0002","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/153537020222700104","article-title":"Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus\u00a0L.)","volume":"227","author":"Abdullaev","year":"2002","journal-title":"Exp Biol Med"},{"key":"10.1111\/and.12568-BIB0003|and12568-cit-0003","first-page":"430","article-title":"In vitro evaluation of the chemopreventive potential of saffron","volume":"54","author":"Abdullaev","year":"2002","journal-title":"Rev invest clin"},{"key":"10.1111\/and.12568-BIB0004|and12568-cit-0004","first-page":"17","article-title":"Cadmium toxicity: a possible cause of male infertility in Nigeria","volume":"6","author":"Akinloye","year":"2006","journal-title":"Reprod Biol"},{"key":"10.1111\/and.12568-BIB0005|and12568-cit-0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1262\/jrd.18110","article-title":"Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis","volume":"54","author":"Amara","year":"2008","journal-title":"J Reprod Dev"},{"key":"10.1111\/and.12568-BIB0006|and12568-cit-0006","volume-title":"Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction","author":"Belsy","year":"1980"},{"key":"10.1111\/and.12568-BIB0007|and12568-cit-0007","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/humupd\/6.2.107","article-title":"Male infertility and environmental exposure to lead and cadmium","volume":"6","author":"Benoff","year":"2000","journal-title":"Hum Reprod Update"},{"key":"10.1111\/and.12568-BIB0008|and12568-cit-0008","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0890-6238(01)00184-8","article-title":"Effect of atenolol on cadmium-induced testicular toxicity in male rats","volume":"15","author":"Biswas","year":"2001","journal-title":"Reprod Toxicol"},{"key":"10.1111\/and.12568-BIB0009|and12568-cit-0009","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ar.21317","article-title":"Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice","volume":"294","author":"Bu","year":"2011","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1111\/and.12568-BIB0010|and12568-cit-0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1532-0456(02)00180-1","article-title":"Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats","volume":"133","author":"Casalino","year":"2002","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1111\/and.12568-BIB0011|and12568-cit-0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cccn.2004.09.012","article-title":"A modified, economic, sensitive method for measuring total antioxidant capacities of human plasma and natural compounds using Indian saffron (Crocus sativus)","volume":"352","author":"Chatterjee","year":"2005","journal-title":"Clin Chim Acta"},{"key":"10.1111\/and.12568-BIB0012|and12568-cit-0012","first-page":"258","article-title":"Effects of chronic cadmium loading on the testis and endocrine function of reproduction in male rats","volume":"54","author":"Chen","year":"2002","journal-title":"Sheng Li Xue Bao"},{"key":"10.1111\/and.12568-BIB0013|and12568-cit-0013","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/01485019208987722","article-title":"Blood concentrations of lead, cadmium, mercury, zinc, and copper and human semen parameters","volume":"29","author":"Chia","year":"1992","journal-title":"Arch Androl"},{"key":"10.1111\/and.12568-BIB0014|and12568-cit-0014","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1042\/bj2300395","article-title":"Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes","volume":"230","author":"Din","year":"1985","journal-title":"Biochem J"},{"key":"10.1111\/and.12568-BIB0015|and12568-cit-0015","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1071\/RD09197","article-title":"Improving the effect of incubation and oxidative stress on thawed spermatozoa from red deer by using different antioxidant treatments","volume":"22","author":"Dom\u00ednguez-Rebolledo","year":"2010","journal-title":"Reprod Fertil Dev"},{"key":"10.1111\/and.12568-BIB0016|and12568-cit-0016","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/taap.1999.8785","article-title":"The antagonistic effect of chlorpromazine on cadmium toxicity","volume":"161","author":"El-Ashmawy","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1111\/and.12568-BIB0017|and12568-cit-0017","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.fct.2004.05.001","article-title":"Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and \u03b2-carotene","volume":"42","author":"El-Demerdash","year":"2004","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/and.12568-BIB0018|and12568-cit-0018","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0304-3835(95)04067-6","article-title":"Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in\u00a0vitro","volume":"100","author":"Escribano","year":"1996","journal-title":"Cancer Lett"},{"key":"10.1111\/and.12568-BIB0019|and12568-cit-0019","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0890-6238(99)00019-2","article-title":"Cadmium affects testes and semen of rabbits exposed before and after puberty","volume":"13","author":"Foote","year":"1999","journal-title":"Reprod Toxicol"},{"key":"10.1111\/and.12568-BIB0020|and12568-cit-0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tox.2008.12.022","article-title":"Protective effect of hemin against cadmium-induced testicular damage in rats","volume":"257","author":"Fouad","year":"2009","journal-title":"Toxicology"},{"key":"10.1111\/and.12568-BIB0021|and12568-cit-0021","first-page":"199","article-title":"Probability to retrieve testicular spermatozoa in azoospermic patients","volume":"2","author":"Glander","year":"2000","journal-title":"Asian J Androl"},{"key":"10.1111\/and.12568-BIB0022|and12568-cit-0022","first-page":"191","article-title":"Light-microscopic and immunopathologic observations on cadmium chloride-induced injury in mature rat testis","volume":"51","author":"Gupta","year":"1967","journal-title":"Am J Pathol"},{"key":"10.1111\/and.12568-BIB0023|and12568-cit-0023","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/jcp.43.3.184","article-title":"Review: assessment of cell proliferation in histological material","volume":"43","author":"Hall","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1111\/and.12568-BIB0024|and12568-cit-0024","first-page":"255","article-title":"Effect of saffron on semen parameters of infertile men","volume":"5","author":"Heidary","year":"2008","journal-title":"Urol J"},{"key":"10.1111\/and.12568-BIB0025|and12568-cit-0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2210-2-7","article-title":"Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice","volume":"2","author":"Hosseinzadeh","year":"2002","journal-title":"BMC Pharmacol"},{"key":"10.1111\/and.12568-BIB0026|and12568-cit-0026","first-page":"387","article-title":"Protective effect of aqueous saffron extract (Crocus sativus Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats","volume":"8","author":"Hosseinzadeh","year":"2005","journal-title":"J Pharm Pharm Sci"},{"key":"10.1111\/and.12568-BIB0027|and12568-cit-0027","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/00039896.1973.10666266","article-title":"Bone changes in experimental chronic cadmium: radiological and biological approaches","volume":"26","author":"Itokawa","year":"1973","journal-title":"Arch Environ Health"},{"key":"10.1111\/and.12568-BIB0028|and12568-cit-0028","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12011-007-8019-1","article-title":"Protective effects of antioxidants against cadmium-induced oxidative damage in rat testes","volume":"120","author":"Kara","year":"2007","journal-title":"Biol Trace Elem Res"},{"key":"10.1111\/and.12568-BIB0029|and12568-cit-0029","first-page":"183","article-title":"Effect of cadmium on the spermatogenesis of Rana hexadactyla Lesson","volume":"35","author":"Kasinathan","year":"1987","journal-title":"Acta Morphol Hung"},{"key":"10.1111\/and.12568-BIB0030|and12568-cit-0030","doi-asserted-by":"crossref","first-page":"356126","DOI":"10.1155\/2012\/356126","article-title":"Genetic variations of glutathione S-transferase influence on blood cadmium concentration","volume":"2012","author":"Khansakorn","year":"2012","journal-title":"J Toxicol"},{"key":"10.1111\/and.12568-BIB0031|and12568-cit-0031","first-page":"44","article-title":"Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice","volume":"5","author":"Khosravan","year":"2002","journal-title":"Arch Iranian Med"},{"key":"10.1111\/and.12568-BIB0032|and12568-cit-0032","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/15287399209531654","article-title":"Role of oxidative stress in single dose, cadmium-induced testicular cancer","volume":"37","author":"Koizumi","year":"1992","journal-title":"J Toxicol Environ Health"},{"key":"10.1111\/and.12568-BIB0033|and12568-cit-0033","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.etap.2005.08.006","article-title":"Influence of combined antioxidants against cadmium induced testicular damage","volume":"21","author":"Koyuturk","year":"2006","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1111\/and.12568-BIB0034|and12568-cit-0034","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ar.1091490112","article-title":"Cadmium-induced injury of the rat testis","volume":"149","author":"Mason","year":"1964","journal-title":"Anat Rec"},{"key":"10.1111\/and.12568-BIB0035|and12568-cit-0035","first-page":"93","article-title":"The effect of nandrolone decanoate on the body, testis and epididymis weight and semen parameters in adult male rats","volume":"32","author":"Mesbah","year":"2007","journal-title":"Iran J Med Sci"},{"key":"10.1111\/and.12568-BIB0036|and12568-cit-0036","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0009-8981(86)90247-0","article-title":"The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis","volume":"155","author":"Michalak","year":"1986","journal-title":"Clin Chim Acta"},{"key":"10.1111\/and.12568-BIB0037|and12568-cit-0037","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2486\/indhealth.47.487","article-title":"Individual susceptibility to cadmium toxicity and metallothionein gene polymorphisms: with references to current status of occupational cadmium exposure","volume":"47","author":"Miura","year":"2009","journal-title":"Ind Health"},{"key":"10.1111\/and.12568-BIB0038|and12568-cit-0038","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1089\/cbr.1995.10.257","article-title":"Saffron chemoprevention in biology and medicine: a review","volume":"10","author":"Nair","year":"1995","journal-title":"Cancer Biother"},{"key":"10.1111\/and.12568-BIB0039|and12568-cit-0039","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.biocel.2004.07.017","article-title":"The spermatogonial stem cell: from basic knowledge to transgenic technology","volume":"37","author":"Olive","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1111\/and.12568-BIB0040|and12568-cit-0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1081\/DCT-100106266","article-title":"Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice","volume":"24","author":"Premkumar","year":"2001","journal-title":"Drug Chem Toxicol"},{"key":"10.1111\/and.12568-BIB0041|and12568-cit-0041","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/ptr.1209","article-title":"Protective effects of saffron (Crocus sativus Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice","volume":"17","author":"Premkumar","year":"2003","journal-title":"Phytother Res"},{"key":"10.1111\/and.12568-BIB0042|and12568-cit-0042","first-page":"59","article-title":"Mutagenic action of cadmium on the sex cells of male mice","volume":"13","author":"Rama\u012dia","year":"1977","journal-title":"Genetika"},{"key":"10.1111\/and.12568-BIB0043|and12568-cit-0043","first-page":"51","article-title":"The effects of pentoxifylline on mouse epididymal sperm parameters, fertilization and cleavage rates after short time preservation","volume":"2","author":"Rashidi","year":"2004","journal-title":"Iran J Reprod Med"},{"key":"10.1111\/and.12568-BIB0044|and12568-cit-0044","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C","article-title":"An update review of saffron and its active constituents","volume":"10","author":"Rios","year":"1996","journal-title":"Phytother Res"},{"key":"10.1111\/and.12568-BIB0045|and12568-cit-0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3904\/kjim.2007.22.4.263","article-title":"Expression of c-FLIP in gastric cancer and its relation to tumor cell proliferation and apoptosis","volume":"22","author":"Ryang","year":"2007","journal-title":"Korean J Intern Med"},{"key":"10.1111\/and.12568-BIB0046|and12568-cit-0046","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11418-006-0120-9","article-title":"Pharmacological activities of crocin in saffron","volume":"61","author":"Soeda","year":"2007","journal-title":"J Nat Med"},{"key":"10.1111\/and.12568-BIB0047|and12568-cit-0047","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i2.10","article-title":"Oxidative mechanisms in the toxicity of chromium and cadmium ions","volume":"20","author":"Stohs","year":"2001","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1111\/and.12568-BIB0048|and12568-cit-0048","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jemt.1171","article-title":"Cadmium distribution and toxicity in tissues of small rodents","volume":"55","author":"\u015awiergosz-Kowalewska","year":"2001","journal-title":"Microsc Res Tech"},{"key":"10.1111\/and.12568-BIB0049|and12568-cit-0049","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/and.12069","article-title":"Antioxidant effect of manganese on the testis structure and sperm parameters of formalin-treated mice","volume":"46","author":"Tajaddini","year":"2014","journal-title":"Andrologia"},{"key":"10.1111\/and.12568-BIB0050|and12568-cit-0050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5271\/sjweh.2065","article-title":"Renal function of workers with low-level cadmium exposure","volume":"13","author":"Verschoor","year":"1987","journal-title":"Scand J Work Environ Health"},{"key":"10.1111\/and.12568-BIB0051|and12568-cit-0051","first-page":"157","article-title":"Carnitine supplementation in human idiopathic asthenospermia: clinical results","volume":"21","author":"Vitali","year":"1995","journal-title":"Drugs Exp Clin Res"},{"key":"10.1111\/and.12568-BIB0052|and12568-cit-0052","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.fct.2007.08.035","article-title":"Effect of Picroliv on cadmium induced testicular damage in rat","volume":"46","author":"Yadav","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/and.12568-BIB0053|and12568-cit-0053","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3346\/jkms.2006.21.3.445","article-title":"Effects of \u03b1-tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis","volume":"21","author":"Yang","year":"2006","journal-title":"J Korean Med Sci"},{"key":"10.1111\/and.12568-BIB0054|and12568-cit-0054","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12011-009-8577-5","article-title":"Cadmium toxicity in spermatogenesis and protective effects of L-carnitine in adult male rats","volume":"137","author":"Yari","year":"2010","journal-title":"Biol Trace Elem Res"},{"key":"10.1111\/and.12568-BIB0055|and12568-cit-0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1023\/A:1009277121164","article-title":"Cadmium induced lipid peroxidation in rat testes and protection by selenium","volume":"12","author":"Yiin","year":"1999","journal-title":"Biometals"},{"key":"10.1111\/and.12568-BIB0056|and12568-cit-0056","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxlet.2004.07.015","article-title":"Cadmium at a non-toxic dose alters gene expression in mouse testes","volume":"154","author":"Zhou","year":"2004","journal-title":"Toxicol Lett"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12568","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12568\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:36:53Z","timestamp":1671539813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,12]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12568","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}