{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:47Z","timestamp":1760029067436},"reference-count":33,"publisher":"Hindawi Limited","issue":"1","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1111\/and.12580","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T15:45:29Z","timestamp":1462203929000},"page":"e12580","source":"Crossref","is-referenced-by-count":9,"title":["Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats"],"prefix":"10.1155","volume":"49","author":[{"given":"A. A.","family":"Fouad","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences; Pharmacology Division; College of Medicine; King Faisal University; Al-Ahsa Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. O.","family":"Qutub","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine; College of Medicine; King Faisal University; Al-Ahsa Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Jresat","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; Pathology Division; College of Medicine; King Faisal University; Al-Ahsa Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"10.1111\/and.12580-BIB0001|and12580-cit-0001","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2174\/092986712799320538","article-title":"Molecular pathways involved in the early and late damage induced by testis ischemia: evidence for a rational pharmacological modulation","volume":"19","author":"Altavilla","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1111\/and.12580-BIB0002|and12580-cit-0002","first-page":"313","article-title":"Protective effects of zofenopril on testicular torsion and detorsion injury in rats","volume":"8","author":"Altunoluk","year":"2011","journal-title":"Urol J"},{"key":"10.1111\/and.12580-BIB0003|and12580-cit-0003","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00345-013-1049-8","article-title":"The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: an experimental study","volume":"31","author":"Bayatli","year":"2013","journal-title":"World J Urol"},{"key":"10.1111\/and.12580-BIB0004|and12580-cit-0004","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/cjpp-2014-0262","article-title":"Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions","volume":"93","author":"Chen","year":"2015","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1111\/and.12580-BIB0005|and12580-cit-0005","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D'Amelio","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1111\/and.12580-BIB0006|and12580-cit-0006","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4111\/kju.2009.50.12.1159","article-title":"Twist and shout: a clinical and experimental review of testicular torsion","volume":"50","author":"Ellati","year":"2009","journal-title":"Korean J Urol"},{"key":"10.1111\/and.12580-BIB0007|and12580-cit-0007","doi-asserted-by":"crossref","first-page":"e80997","DOI":"10.1371\/journal.pone.0080997","article-title":"Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia","volume":"8","author":"Feng","year":"2013","journal-title":"PLoS One"},{"key":"10.1111\/and.12580-BIB0008|and12580-cit-0008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mam.2004.02.020","article-title":"Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury","volume":"25","author":"Filho","year":"2004","journal-title":"Mol Aspects Med"},{"key":"10.1111\/and.12580-BIB0009|and12580-cit-0009","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.reprotox.2015.06.049","article-title":"Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas\/FasL pathway and Hsp72 expression","volume":"57","author":"Guo","year":"2015","journal-title":"Reprod Toxicol"},{"key":"10.1111\/and.12580-BIB0010|and12580-cit-0010","first-page":"2","article-title":"Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1111\/and.12580-BIB0011|and12580-cit-0011","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1095\/biolreprod64.3.946","article-title":"Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis","volume":"64","author":"Koji","year":"2001","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12580-BIB0012|and12580-cit-0012","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jpedsurg.2011.09.035","article-title":"Inhaled hydrogen gas therapy for prevention of testicular ischemia\/reperfusion injury in rats","volume":"47","author":"Lee","year":"2012","journal-title":"J Pediatr Surg"},{"key":"10.1111\/and.12580-BIB0013|and12580-cit-0013","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ptr.3238","article-title":"Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats","volume":"25","author":"Li","year":"2011","journal-title":"Phytother Res"},{"key":"10.1111\/and.12580-BIB0014|and12580-cit-0014","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6882-14-19","article-title":"The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis","volume":"14","author":"Lin","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1111\/and.12580-BIB0015|and12580-cit-0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11418-011-0592-0","article-title":"San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia\/reoxygenation injury via inhibition of\u00a0oxidative stress-induced apoptosis","volume":"66","author":"Liou","year":"2012","journal-title":"J Nat Med"},{"key":"10.1111\/and.12580-BIB0016|and12580-cit-0016","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s11064-012-0771-8","article-title":"The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats","volume":"37","author":"Liu","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1111\/and.12580-BIB0017|and12580-cit-0017","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1095\/biolreprod63.5.1465","article-title":"Molecular pathway of germ cell apoptosis following ischemia\/reperfusion of the rat testis","volume":"63","author":"Lysiak","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1111\/and.12580-BIB0018|and12580-cit-0018","doi-asserted-by":"publisher","DOI":"10.1111\/and.12503","article-title":"Protective role of methylprednisolone and heparin in ischaemic-reperfusion injury of the rat testicle","author":"Mertoglu","year":"2015","journal-title":"Andrologia"},{"key":"10.1111\/and.12580-BIB0019|and12580-cit-0019","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.urology.2014.07.022","article-title":"Beneficial effect of nifedipine on testicular torsion-detorsion injury in rats","volume":"84","author":"Me\u0161trovi\u0107","year":"2014","journal-title":"Urology"},{"key":"10.1111\/and.12580-BIB0020|and12580-cit-0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.2047-2927.2013.00154.x","article-title":"Effects of ischaemic post-conditioning on the early and late testicular damage after experimental testis ischaemia-reperfusion","volume":"2","author":"Minutoli","year":"2014","journal-title":"Andrology"},{"key":"10.1111\/and.12580-BIB0021|and12580-cit-0021","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.juro.2014.11.086","article-title":"The protective effect of apocynin on testicular ischemia-reperfusion injury","volume":"193","author":"Ozbek","year":"2015","journal-title":"J Urol"},{"key":"10.1111\/and.12580-BIB0022|and12580-cit-0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/13880209.2010.493179","article-title":"Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARgamma and inhibiting TGFbeta1","volume":"49","author":"Qiao","year":"2010","journal-title":"Pharm Biol"},{"key":"10.1111\/and.12580-BIB0023|and12580-cit-0023","first-page":"127","volume-title":"Immunohistochemical Staining Methods","author":"Rasmussen","year":"2009"},{"key":"10.1111\/and.12580-BIB0024|and12580-cit-0024","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/and.12204","article-title":"Protective effect of ebselen on experimental testicular torsion and detorsion injury","volume":"46","author":"Rifaioglu","year":"2014","journal-title":"Andrologia"},{"key":"10.1111\/and.12580-BIB0025|and12580-cit-0025","first-page":"835","article-title":"Testicular torsion: diagnosis, evaluation, and management","volume":"88","author":"Sharp","year":"2013","journal-title":"Am Fam Physician"},{"key":"10.1111\/and.12580-BIB0026|and12580-cit-0026","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00498251003663724","article-title":"Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives","volume":"40","author":"Srinivas","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1111\/and.12580-BIB0027|and12580-cit-0027","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.fertnstert.2009.04.026","article-title":"Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model","volume":"92","author":"Sukhotnik","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1111\/and.12580-BIB0028|and12580-cit-0028","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbrc.2015.07.138","article-title":"Baicalin attenuates angiotensin II-induced endothelial\u00a0dysfunction","volume":"465","author":"Wei","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/and.12580-BIB0029|and12580-cit-0029","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1016\/j.fct.2012.05.061","article-title":"Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative\/nitrative stress which is attenuated by pretreatment with baicalin","volume":"50","author":"Xu","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1111\/and.12580-BIB0030|and12580-cit-0030","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00726-015-1995-0","article-title":"Taurine\u00a0increases testicular function in aged rats by inhibiting oxidative stress and apoptosis","volume":"47","author":"Yang","year":"2015","journal-title":"Amino Acids"},{"key":"10.1111\/and.12580-BIB0031|and12580-cit-0031","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jpedsurg.2013.08.028","article-title":"The short term effects of resveratrol on ischemia-reperfusion injury in rat testis","volume":"49","author":"Yulug","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1111\/and.12580-BIB0032|and12580-cit-0032","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/02699052.2013.860469","article-title":"Baicalin protects PC-12 cells from oxidative stress induced by hydrogen peroxide via anti-apoptotic effects","volume":"28","author":"Zheng","year":"2014","journal-title":"Brain Inj"},{"key":"10.1111\/and.12580-BIB0033|and12580-cit-0033","doi-asserted-by":"crossref","first-page":"898056","DOI":"10.1155\/2014\/898056","article-title":"Protective effects of lipoxin A4 in testis injury following testicular torsion and detorsion in rats","volume":"2014","author":"Zhou","year":"2014","journal-title":"Mediators Inflamm"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12580","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12580\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:37:42Z","timestamp":1671539862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12580","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}