{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:55:50Z","timestamp":1781700950977,"version":"3.54.5"},"reference-count":30,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Andrologia"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1111\/and.12607","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T16:42:59Z","timestamp":1462380179000},"page":"e12607","source":"Crossref","is-referenced-by-count":15,"title":["Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats"],"prefix":"10.1155","volume":"49","author":[{"given":"E.","family":"Alkan","sequence":"first","affiliation":[{"name":"Department of Urology; Memorial Sisli Hospital; Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Ugan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine; Department of Pharmacology; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Basar","sequence":"additional","affiliation":[{"name":"Department of Urology; Memorial Sisli Hospital; Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Halici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine; Department of Pharmacology; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Karakus","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary; Department of Pharmacology and Toxicology; Ataturk University; Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Balbay","sequence":"additional","affiliation":[{"name":"Department of Urology; Memorial Sisli Hospital; Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Un","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy; Department of Biochemistry; Ibrahim Cecen University; Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"key":"10.1111\/and.12607-BIB0001|and12607-cit-0001","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0094-0143(05)70134-8","article-title":"Pharmacology of erectile function and dysfunction","volume":"28","author":"Andersson","year":"2001","journal-title":"Urol Clin North Am"},{"key":"10.1111\/and.12607-BIB0002|and12607-cit-0002","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF02576230","article-title":"Increased endothelin plasma concentrations in patients with coronary-artery disease or hyperlipoproteinemia without coronary events","volume":"193","author":"Arendt","year":"1993","journal-title":"Res Exp Med"},{"key":"10.1111\/and.12607-BIB0003|and12607-cit-0003","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1464-410X.1995.tb07675.x","article-title":"The density and distribution of endothelin 1 and endothelin receptor subtypes in normal and diabetic rat corpus cavernosum","volume":"76","author":"Bell","year":"1995","journal-title":"Br J Urol"},{"key":"10.1111\/and.12607-BIB0004|and12607-cit-0004","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.neurobiolaging.2005.08.015","article-title":"The impact of diabetes on cognition: what can be learned from rodent models?","volume":"26","author":"Biessels","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1111\/and.12607-BIB0005|and12607-cit-0005","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1002\/j.1939-4640.2003.tb02743.x","article-title":"Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease","volume":"24","author":"Bivalacqua","year":"2003","journal-title":"J Androl"},{"key":"10.1111\/and.12607-BIB0006|and12607-cit-0006","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1111\/j.1743-6109.2010.01762.x","article-title":"Emerging role for TNF-alpha in erectile dysfunction","volume":"7","author":"Carneiro","year":"2010","journal-title":"J. Sex. Med."},{"key":"10.1111\/and.12607-BIB0007|and12607-cit-0007","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s40618-015-0282-y","article-title":"The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus","volume":"38","author":"Cayir","year":"2015","journal-title":"J Endocrinol Invest"},{"key":"10.1111\/and.12607-BIB0008|and12607-cit-0008","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.2042-7158.2012.01565.x","article-title":"Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats","volume":"65","author":"Cheng","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"10.1111\/and.12607-BIB0009|and12607-cit-0009","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/andr.12004","article-title":"Comparisons of apomorphine-induced erection and spontaneous erection in rats by telemetric assessment of intracavernosal pressure","volume":"3","author":"Choo","year":"2015","journal-title":"Andrology"},{"key":"10.1111\/and.12607-BIB0010|and12607-cit-0010","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/S0022-5347(01)67390-7","article-title":"Endothelin-1 as a putative modulator of erectile dysfunction. 1. Characteristics of contraction of isolated corporal tissue strips","volume":"153","author":"Christ","year":"1995","journal-title":"J Urol"},{"key":"10.1111\/and.12607-BIB0011|and12607-cit-0011","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1152\/ajpregu.2000.279.1.R25","article-title":"Receptor-specific influence of endothelin-1 in the erectile response of the rat","volume":"279","author":"Dai","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1111\/and.12607-BIB0012|and12607-cit-0012","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/bcpt.12318","article-title":"Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain","volume":"116","author":"Demir","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1111\/and.12607-BIB0013|and12607-cit-0013","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.lfs.2012.04.040","article-title":"Complex expression changes of the placental endothelin system in early and late onset preeclampsia, fetal growth restriction and gestational diabetes","volume":"91","author":"Dieber-Rotheneder","year":"2012","journal-title":"Life Sci"},{"key":"10.1111\/and.12607-BIB0014|and12607-cit-0014","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1464-410X.2005.05780.x","article-title":"Plasma levels of endothelin-1, angiotensin II, nitric oxide and prostaglandin E in the venous and cavernosal blood of patients with erectile dysfunction","volume":"96","author":"El Melegy","year":"2005","journal-title":"BJU Int"},{"key":"10.1111\/and.12607-BIB0015|and12607-cit-0015","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0022-5347(01)64125-9","article-title":"Endothelin-1 in diabetic and nondiabetic men with erectile dysfunction","volume":"158","author":"Francavilla","year":"1997","journal-title":"J Urol"},{"key":"10.1111\/and.12607-BIB0016|and12607-cit-0016","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exger.2014.10.018","article-title":"Effects of age and caloric restriction on the cardiac and coronary response to endothelin-1 in rats","volume":"60","author":"Granado","year":"2014","journal-title":"Exp Gerontol"},{"key":"10.1111\/and.12607-BIB0017|and12607-cit-0017","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/molehr\/8.12.1053","article-title":"Expression and regulation of endothelin-1 and its receptors in human penile smooth muscle cells","volume":"8","author":"Granchi","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1111\/and.12607-BIB0018|and12607-cit-0018","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0022-5347(17)38543-9","article-title":"The Characterization of a Bioassay of Erectile Function in a Rat Model","volume":"145","author":"Heaton","year":"1991","journal-title":"J Urol"},{"key":"10.1111\/and.12607-BIB0019|and12607-cit-0019","first-page":"206","article-title":"Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease","volume":"31","author":"Karalliedde","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/and.12607-BIB0020|and12607-cit-0020","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/1389450003349164","article-title":"Normal and pathological erectile function: the potential clinical role of endothelin-1 antagonists","volume":"1","author":"Khan","year":"2000","journal-title":"Curr Drug Targets"},{"key":"10.1111\/and.12607-BIB0021|and12607-cit-0021","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0094-0143(05)70132-4","article-title":"Epidemiology of erectile dysfunction","volume":"28","author":"Lewis","year":"2001","journal-title":"Urol Clin North Am"},{"key":"10.1111\/and.12607-BIB0022|and12607-cit-0022","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1111\/and.12607-BIB0023|and12607-cit-0023","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1745-7262.2006.00223.x","article-title":"Pathophysiology and treatment of diabetic erectile dysfunction","volume":"8","author":"Moore","year":"2006","journal-title":"Asian J. Androl."},{"key":"10.1111\/and.12607-BIB0024|and12607-cit-0024","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.etap.2015.01.002","article-title":"Tnf-alpha inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy","volume":"39","author":"Saritemur","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1111\/and.12607-BIB0025|and12607-cit-0025","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1164\/rccm.200404-445OC","article-title":"Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension","volume":"170","author":"Sitbon","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1111\/and.12607-BIB0026|and12607-cit-0026","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF00403325","article-title":"Elevated plasma endothelin in patients with diabetes mellitus","volume":"33","author":"Takahashi","year":"1990","journal-title":"Diabetologia"},{"key":"10.1111\/and.12607-BIB0027|and12607-cit-0027","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1743-6109.2005.20103.x","article-title":"Pathophysiology of erectile dysfunction","volume":"2","author":"Tejada","year":"2005","journal-title":"J. Sex. Med."},{"key":"10.1111\/and.12607-BIB0028|and12607-cit-0028","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jdiacomp.2010.03.003","article-title":"Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management","volume":"25","author":"Thorve","year":"2011","journal-title":"J Diabetes Complications"},{"key":"10.1111\/and.12607-BIB0029|and12607-cit-0029","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1111\/and.12607-BIB0030|and12607-cit-0030","first-page":"348","article-title":"Systemic hypertension augments, whereas insulin-dependent diabetes down-regulates, endothelin A receptor expression in the mammary artery in coronary artery disease patients","volume":"16","author":"Zygalaki","year":"2009","journal-title":"Cardiol. J."}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fand.12607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/and.12607\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T12:38:00Z","timestamp":1671539880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/and.12607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1111\/and.12607","archive":["Portico"],"relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5,4]]}}}